登録情報 データベース : PDB / ID : 3rc0 構造の表示 ダウンロードとリンクタイトル Human SETD6 in complex with RelA Lys310 peptide 要素N-lysine methyltransferase SETD6 Transcription factor p65 peptide 詳細キーワード TRANSFERASE / Epigenetics / protein lysine monomethylation / Mammalian nuclear factor kB (NF-kB)機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
peptidyl-lysine monomethylation / acetaldehyde metabolic process / prolactin signaling pathway / DEx/H-box helicases activate type I IFN and inflammatory cytokines production / NF-kappaB p50/p65 complex / IkBA variant leads to EDA-ID / positive regulation of Schwann cell differentiation / cellular response to peptidoglycan / Regulated proteolysis of p75NTR / ankyrin repeat binding ... peptidyl-lysine monomethylation / acetaldehyde metabolic process / prolactin signaling pathway / DEx/H-box helicases activate type I IFN and inflammatory cytokines production / NF-kappaB p50/p65 complex / IkBA variant leads to EDA-ID / positive regulation of Schwann cell differentiation / cellular response to peptidoglycan / Regulated proteolysis of p75NTR / ankyrin repeat binding / RIP-mediated NFkB activation via ZBP1 / SUMOylation of immune response proteins / protein-lysine N-methyltransferase activity / CLEC7A/inflammasome pathway / S-adenosyl-L-methionine binding / negative regulation of protein sumoylation / defense response to tumor cell / postsynapse to nucleus signaling pathway / nucleotide-binding oligomerization domain containing 2 signaling pathway / cellular response to interleukin-6 / Interleukin-1 processing / actinin binding / cellular response to angiotensin / response to UV-B / NF-kappaB complex / negative regulation of non-canonical NF-kappaB signal transduction / positive regulation of leukocyte adhesion to vascular endothelial cell / Regulation of NFE2L2 gene expression / interleukin-1-mediated signaling pathway / vascular endothelial growth factor signaling pathway / toll-like receptor 4 signaling pathway / stem cell population maintenance / cellular response to hepatocyte growth factor stimulus / positive regulation of amyloid-beta formation / positive regulation of miRNA metabolic process / negative regulation of NF-kappaB transcription factor activity / response to cobalamin / positive regulation of T cell receptor signaling pathway / non-canonical NF-kappaB signal transduction / phosphate ion binding / cellular response to lipoteichoic acid / TRAF6 mediated NF-kB activation / response to muramyl dipeptide / The NLRP3 inflammasome / general transcription initiation factor binding / Transcriptional Regulation by VENTX / NF-kappaB binding / hair follicle development / positive regulation of vascular endothelial growth factor production / neuropeptide signaling pathway / canonical NF-kappaB signal transduction / RNA polymerase II core promoter sequence-specific DNA binding / response to amino acid / cellular response to interleukin-1 / cellular defense response / Purinergic signaling in leishmaniasis infection / response to cAMP / tumor necrosis factor-mediated signaling pathway / response to muscle stretch / positive regulation of interleukin-12 production / negative regulation of insulin receptor signaling pathway / NF-kB is activated and signals survival / CD209 (DC-SIGN) signaling / response to interleukin-1 / negative regulation of angiogenesis / 転移酵素; 一炭素原子の基を移すもの; メチル基を移すもの / : / negative regulation of miRNA transcription / liver development / positive regulation of interleukin-1 beta production / response to cytokine / positive regulation of interleukin-8 production / response to ischemia / response to progesterone / stem cell differentiation / Dectin-1 mediated noncanonical NF-kB signaling / negative regulation of extrinsic apoptotic signaling pathway / Activation of NF-kappaB in B cells / animal organ morphogenesis / RNA polymerase II transcription regulatory region sequence-specific DNA binding / peptide binding / TAK1-dependent IKK and NF-kappa-B activation / protein catabolic process / response to insulin / negative regulation of protein catabolic process / chromatin DNA binding / PKMTs methylate histone lysines / CLEC7A (Dectin-1) signaling / cytokine-mediated signaling pathway / transcription coactivator binding / DNA-binding transcription repressor activity, RNA polymerase II-specific / positive regulation of miRNA transcription / histone deacetylase binding / FCERI mediated NF-kB activation / Transcriptional regulation of white adipocyte differentiation / cellular response to hydrogen peroxide / Interleukin-1 signaling / cellular response to nicotine / positive regulation of non-canonical NF-kappaB signal transduction / SARS-CoV-1 activates/modulates innate immune responses 類似検索 - 分子機能 N-lysine methyltransferase SETD6 / SETD6, SET domain / set domain protein methyltransferase, domain 1 / set domain protein methyltransferase, domain 1 / set domain protein methyltransferase, domain 2 / Rubisco LSMT, substrate-binding domain / Rubisco LSMT, substrate-binding domain / Rubisco LSMT, substrate-binding domain superfamily / Rubisco LSMT substrate-binding / Transcription factor RelA (p65) ... N-lysine methyltransferase SETD6 / SETD6, SET domain / set domain protein methyltransferase, domain 1 / set domain protein methyltransferase, domain 1 / set domain protein methyltransferase, domain 2 / Rubisco LSMT, substrate-binding domain / Rubisco LSMT, substrate-binding domain / Rubisco LSMT, substrate-binding domain superfamily / Rubisco LSMT substrate-binding / Transcription factor RelA (p65) / NF-kappa-B/Dorsal / Rel homology domain, conserved site / NFkappaB IPT domain / NF-kappa-B/Rel/dorsal domain signature. / Rel homology domain (RHD), DNA-binding domain / Rel homology dimerisation domain / Rel homology DNA-binding domain / Rel homology dimerisation domain / NF-kappa-B/Rel/dorsal domain profile. / Rel homology domain (RHD), DNA-binding domain superfamily / ig-like, plexins, transcription factors / IPT domain / SET domain superfamily / SET domain / SET domain profile. / SET domain / p53-like transcription factor, DNA-binding / Immunoglobulin E-set / Immunoglobulin-like fold / Alpha-Beta Complex / Alpha Beta 類似検索 - ドメイン・相同性 S-ADENOSYLMETHIONINE / Transcription factor p65 / N-lysine methyltransferase SETD6 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 多重同系置換 / 解像度 : 2.19 Å 詳細データ登録者 Chang, Y. / Levy, D. / Horton, J.R. / Peng, J. / Zhang, X. / Gozani, O. / Cheng, X. 引用ジャーナル : Nucleic Acids Res. / 年 : 2011タイトル : Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling.著者 : Chang, Y. / Levy, D. / Horton, J.R. / Peng, J. / Zhang, X. / Gozani, O. / Cheng, X. 履歴 登録 2011年3月30日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2011年5月25日 Provider : repository / タイプ : Initial release改定 1.1 2011年7月13日 Group : Version format compliance改定 1.2 2011年8月10日 Group : Database references改定 1.3 2011年9月7日 Group : Database references改定 1.4 2023年9月13日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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