登録情報 | データベース: PDB / ID: 3q4a |
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タイトル | Crystal structure of the TPR domain of CHIP complexed with phosphorylated Smad1 peptide |
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要素 | - STIP1 homology and U box-containing protein 1
- Smad1 peptide
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キーワード | LIGASE/TRANSCRIPTION / E3 ubiquitin ligase / LIGASE-TRANSCRIPTION complex |
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機能・相同性 | 機能・相同性情報
mesodermal cell fate commitment / positive regulation of chaperone-mediated protein complex assembly / homomeric SMAD protein complex / Downregulation of TGF-beta receptor signaling / osteoblast fate commitment / regulation of glucocorticoid metabolic process / Downregulation of ERBB2 signaling / SMAD protein complex / Regulation of TNFR1 signaling / Regulation of necroptotic cell death ...mesodermal cell fate commitment / positive regulation of chaperone-mediated protein complex assembly / homomeric SMAD protein complex / Downregulation of TGF-beta receptor signaling / osteoblast fate commitment / regulation of glucocorticoid metabolic process / Downregulation of ERBB2 signaling / SMAD protein complex / Regulation of TNFR1 signaling / Regulation of necroptotic cell death / RUNX2 regulates bone development / Regulation of PTEN stability and activity / co-SMAD binding / Regulation of RUNX2 expression and activity / heteromeric SMAD protein complex / negative regulation of muscle cell differentiation / positive regulation of cartilage development / ubiquitin conjugating enzyme complex / primary miRNA binding / DEAD/H-box RNA helicase binding / positive regulation of ERAD pathway / positive regulation of mitophagy / positive regulation of smooth muscle cell apoptotic process / gamete generation / hindbrain development / cardiac conduction system development / primary miRNA processing / nuclear inclusion body / Signaling by BMP / Antigen processing: Ubiquitination & Proteasome degradation / embryonic pattern specification / misfolded protein binding / SMAD protein signal transduction / I-SMAD binding / protein folding chaperone complex / cartilage development / cellular response to misfolded protein / Cardiogenesis / positive regulation of ubiquitin-protein transferase activity / nuclear inner membrane / ubiquitin-ubiquitin ligase activity / cardiac muscle cell proliferation / ureteric bud development / midbrain development / chaperone-mediated autophagy / homeostatic process / TPR domain binding / positive regulation of sprouting angiogenesis / protein quality control for misfolded or incompletely synthesized proteins / protein monoubiquitination / negative regulation of smooth muscle cell apoptotic process / R-SMAD binding / protein K63-linked ubiquitination / positive regulation of proteolysis / protein maturation / cellular response to organic cyclic compound / anatomical structure morphogenesis / protein autoubiquitination / BMP signaling pathway / positive regulation of osteoblast differentiation / ERAD pathway / ubiquitin ligase complex / endoplasmic reticulum unfolded protein response / heat shock protein binding / Hsp70 protein binding / ossification / transforming growth factor beta receptor signaling pathway / negative regulation of protein binding / positive regulation of protein ubiquitination / response to ischemia / G protein-coupled receptor binding / negative regulation of transforming growth factor beta receptor signaling pathway / Hsp90 protein binding / RING-type E3 ubiquitin transferase / bone development / kinase binding / positive regulation of miRNA transcription / Z disc / protein polyubiquitination / ubiquitin-protein transferase activity / MAPK cascade / ubiquitin protein ligase activity / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / protein folding / protein-macromolecule adaptor activity / cellular response to heat / protein-folding chaperone binding / cellular response to hypoxia / ubiquitin-dependent protein catabolic process / DNA-binding transcription activator activity, RNA polymerase II-specific / proteasome-mediated ubiquitin-dependent protein catabolic process / transcription by RNA polymerase II / cell differentiation / protein stabilization / DNA-binding transcription factor activity, RNA polymerase II-specific / Ub-specific processing proteases / protein ubiquitination / inflammatory response / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity類似検索 - 分子機能 CHIP, N-terminal tetratricopeptide repeat domain / CHIP/LubX , U box domain / CHIP N-terminal tetratricopeptide repeat domain / MAD homology, MH1 / Dwarfin / SMAD MH1 domain superfamily / MAD homology domain 1 (MH1) profile. / SMAD domain, Dwarfin-type / MH2 domain / MAD homology domain 2 (MH2) profile. ...CHIP, N-terminal tetratricopeptide repeat domain / CHIP/LubX , U box domain / CHIP N-terminal tetratricopeptide repeat domain / MAD homology, MH1 / Dwarfin / SMAD MH1 domain superfamily / MAD homology domain 1 (MH1) profile. / SMAD domain, Dwarfin-type / MH2 domain / MAD homology domain 2 (MH2) profile. / Domain B in dwarfin family proteins / MAD homology 1, Dwarfin-type / MH1 domain / Domain A in dwarfin family proteins / Anaphase-promoting complex, cyclosome, subunit 3 / U-box domain / SMAD-like domain superfamily / U-box domain profile. / Modified RING finger domain / U-box domain / Tetratricopeptide repeat domain / SMAD/FHA domain superfamily / TPR repeat region circular profile. / TPR repeat profile. / Tetratricopeptide repeats / Tetratricopeptide repeat / Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat / Alpha Horseshoe / Tetratricopeptide-like helical domain superfamily / Zinc finger, RING/FYVE/PHD-type / Mainly Alpha類似検索 - ドメイン・相同性 Mothers against decapentaplegic homolog 1 / E3 ubiquitin-protein ligase CHIP類似検索 - 構成要素 |
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生物種 | Mus musculus (ハツカネズミ) Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.542 Å |
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データ登録者 | Wang, L. / Chen, L. / Wu, J.W. |
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引用 | ジャーナル: J.Biol.Chem. / 年: 2011 タイトル: Molecular Mechanism of the Negative Regulation of Smad1/5 Protein by Carboxyl Terminus of Hsc70-interacting Protein (CHIP). 著者: Wang, L. / Liu, Y.T. / Hao, R. / Chen, L. / Chang, Z. / Wang, H.R. / Wang, Z.X. / Wu, J.W. |
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履歴 | 登録 | 2010年12月23日 | 登録サイト: RCSB / 処理サイト: PDBJ |
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改定 1.0 | 2011年3月16日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Version format compliance |
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改定 1.2 | 2023年11月1日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_leaving_atom_flag / _struct_ref_seq_dif.details |
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