登録情報 | データベース: PDB / ID: 3q3t |
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タイトル | Alkyl Amine Renin Inhibitors: Filling S1 from S3 |
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要素 | Renin |
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キーワード | HYDROLASE/HYDROLASE INHIBITOR / aspartate protease / hypertension / renin inhibitors / glycoprotein / zymogen / HYDROLASE-HYDROLASE INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
renin / juxtaglomerular apparatus development / mesonephros development / response to cGMP / renin-angiotensin regulation of aldosterone production / drinking behavior / regulation of MAPK cascade / response to immobilization stress / amyloid-beta metabolic process / angiotensin maturation ...renin / juxtaglomerular apparatus development / mesonephros development / response to cGMP / renin-angiotensin regulation of aldosterone production / drinking behavior / regulation of MAPK cascade / response to immobilization stress / amyloid-beta metabolic process / angiotensin maturation / Metabolism of Angiotensinogen to Angiotensins / cell maturation / insulin-like growth factor receptor binding / response to cAMP / hormone-mediated signaling pathway / kidney development / regulation of blood pressure / male gonad development / cellular response to xenobiotic stimulus / apical part of cell / peptidase activity / response to lipopolysaccharide / aspartic-type endopeptidase activity / signaling receptor binding / proteolysis / extracellular space / extracellular region / plasma membrane類似検索 - 分子機能 Renin-like domain / Aspartic peptidase, N-terminal / A1 Propeptide / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site ...Renin-like domain / Aspartic peptidase, N-terminal / A1 Propeptide / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Aspartic peptidase domain superfamily / Beta Barrel / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.6 Å |
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データ登録者 | Wu, Z. / McKeever, B. |
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引用 | ジャーナル: Bioorg.Med.Chem.Lett. / 年: 2011 タイトル: Biphenyl/diphenyl ether renin inhibitors: Filling the S1 pocket of renin via the S3 pocket. 著者: Yuan, J. / Simpson, R.D. / Zhao, W. / Tice, C.M. / Xu, Z. / Cacatian, S. / Jia, L. / Flaherty, P.T. / Guo, J. / Ishchenko, A. / Wu, Z. / McKeever, B.M. / Scott, B.B. / Bukhtiyarov, Y. / ...著者: Yuan, J. / Simpson, R.D. / Zhao, W. / Tice, C.M. / Xu, Z. / Cacatian, S. / Jia, L. / Flaherty, P.T. / Guo, J. / Ishchenko, A. / Wu, Z. / McKeever, B.M. / Scott, B.B. / Bukhtiyarov, Y. / Berbaum, J. / Panemangalore, R. / Bentley, R. / Doe, C.P. / Harrison, R.K. / McGeehan, G.M. / Singh, S.B. / Dillard, L.W. / Baldwin, J.J. / Claremon, D.A. |
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履歴 | 登録 | 2010年12月22日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2011年8月3日 | Provider: repository / タイプ: Initial release |
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改定 2.0 | 2020年7月29日 | Group: Atomic model / Data collection ...Atomic model / Data collection / Derived calculations / Structure summary カテゴリ: atom_site / chem_comp ...atom_site / chem_comp / entity / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / struct_asym / struct_conn / struct_site / struct_site_gen Item: _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ..._atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_atom_id / _atom_site.auth_comp_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_atom_id / _atom_site.label_comp_id / _atom_site.label_entity_id / _atom_site.type_symbol / _chem_comp.name / _chem_comp.type / _pdbx_entity_nonpoly.comp_id / _pdbx_entity_nonpoly.entity_id / _pdbx_entity_nonpoly.name / _pdbx_struct_assembly_gen.asym_id_list / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id 解説: Carbohydrate remediation / Provider: repository / タイプ: Remediation |
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改定 2.1 | 2021年3月31日 | Group: Source and taxonomy / Structure summary / カテゴリ: chem_comp / entity_src_gen Item: _chem_comp.pdbx_synonyms / _entity_src_gen.pdbx_host_org_cell_line / _entity_src_gen.pdbx_host_org_strain |
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改定 2.2 | 2023年9月13日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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