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- PDB-3op0: Crystal structure of Cbl-c (Cbl-3) TKB domain in complex with EGF... -
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Basic information
Entry | Database: PDB / ID: 3op0 | ||||||
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Title | Crystal structure of Cbl-c (Cbl-3) TKB domain in complex with EGFR pY1069 peptide | ||||||
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![]() | SIGNALING PROTEIN/SIGNALING PROTEIN REGULATOR / Structural Genomics / Structural Genomics Consortium / SGC / Signal transduction protein / SH3-binding protein / SIGNALING PROTEIN-SIGNALING PROTEIN REGULATOR complex | ||||||
Function / homology | ![]() response to glial cell derived neurotrophic factor / negative regulation of epidermal growth factor-activated receptor activity / response to hydroxyisoflavone / multivesicular body, internal vesicle lumen / positive regulation of prolactin secretion / negative regulation of cardiocyte differentiation / positive regulation of protein kinase C activity / diterpenoid metabolic process / Shc-EGFR complex / ovulation cycle ...response to glial cell derived neurotrophic factor / negative regulation of epidermal growth factor-activated receptor activity / response to hydroxyisoflavone / multivesicular body, internal vesicle lumen / positive regulation of prolactin secretion / negative regulation of cardiocyte differentiation / positive regulation of protein kinase C activity / diterpenoid metabolic process / Shc-EGFR complex / ovulation cycle / Inhibition of Signaling by Overexpressed EGFR / epidermal growth factor receptor activity / EGFR interacts with phospholipase C-gamma / positive regulation of mucus secretion / response to UV-A / epidermal growth factor binding / PLCG1 events in ERBB2 signaling / tongue development / midgut development / ERBB2-EGFR signaling pathway / hydrogen peroxide metabolic process / PTK6 promotes HIF1A stabilization / digestive tract morphogenesis / epidermal growth factor receptor binding / morphogenesis of an epithelial fold / ERBB2 Activates PTK6 Signaling / intracellular vesicle / Signaling by EGFR / response to cobalamin / transmembrane receptor protein tyrosine kinase activator activity / protein tyrosine kinase activator activity / negative regulation of epidermal growth factor receptor signaling pathway / Signaling by ERBB4 / eyelid development in camera-type eye / regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / protein insertion into membrane / cerebral cortex cell migration / ERBB2 Regulates Cell Motility / Respiratory syncytial virus (RSV) attachment and entry / regulation of JNK cascade / : / PI3K events in ERBB2 signaling / positive regulation of cyclin-dependent protein serine/threonine kinase activity / negative regulation of mitotic cell cycle / hair follicle development / MAP kinase kinase kinase activity / Estrogen-dependent nuclear events downstream of ESR-membrane signaling / embryonic placenta development / positive regulation of bone resorption / positive regulation of G1/S transition of mitotic cell cycle / GAB1 signalosome / salivary gland morphogenesis / peptidyl-tyrosine autophosphorylation / regulation of peptidyl-tyrosine phosphorylation / positive regulation of phosphorylation / positive regulation of glial cell proliferation / positive regulation of vasoconstriction / Signaling by ERBB2 / cellular response to epidermal growth factor stimulus / GRB2 events in EGFR signaling / SHC1 events in EGFR signaling / EGFR Transactivation by Gastrin / cellular response to cadmium ion / positive regulation of DNA repair / GRB2 events in ERBB2 signaling / TFAP2 (AP-2) family regulates transcription of growth factors and their receptors / phosphotyrosine residue binding / transmembrane receptor protein tyrosine kinase activity / SHC1 events in ERBB2 signaling / positive regulation of synaptic transmission, glutamatergic / cellular response to dexamethasone stimulus / ossification / neurogenesis / regulation of ERK1 and ERK2 cascade / basal plasma membrane / neuron projection morphogenesis / positive regulation of superoxide anion generation / negative regulation of MAP kinase activity / positive regulation of DNA replication / epithelial cell proliferation / Signal transduction by L1 / cellular response to estradiol stimulus / positive regulation of epithelial cell proliferation / NOTCH3 Activation and Transmission of Signal to the Nucleus / astrocyte activation / liver regeneration / positive regulation of protein localization to plasma membrane / EGFR downregulation / cellular response to amino acid stimulus / positive regulation of smooth muscle cell proliferation / Signaling by ERBB2 TMD/JMD mutants / positive regulation of MAP kinase activity / lung development / clathrin-coated endocytic vesicle membrane / Constitutive Signaling by EGFRvIII / RING-type E3 ubiquitin transferase / Signaling by ERBB2 ECD mutants / Signaling by ERBB2 KD Mutants / epidermal growth factor receptor signaling pathway / negative regulation of protein catabolic process Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | ![]() ![]() ![]() | ||||||
![]() | Chaikuad, A. / Guo, K. / Cooper, C.D.O. / Ayinampudi, V. / Krojer, T. / Ugochukwu, E. / Muniz, J.R.C. / Vollmar, M. / Canning, P. / von Delft, F. ...Chaikuad, A. / Guo, K. / Cooper, C.D.O. / Ayinampudi, V. / Krojer, T. / Ugochukwu, E. / Muniz, J.R.C. / Vollmar, M. / Canning, P. / von Delft, F. / Arrowsmith, C.H. / Weigelt, J. / Edwards, A.M. / Bountra, C. / Bullock, A. / Structural Genomics Consortium (SGC) | ||||||
![]() | ![]() Title: Crystal structure of Cbl-c (Cbl-3) TKB domain in complex with EGFR pY1069 peptide Authors: Chaikuad, A. / Guo, K. / Cooper, C.D.O. / Ayinampudi, V. / Krojer, T. / Ugochukwu, E. / Muniz, J.R.C. / Vollmar, M. / Canning, P. / von Delft, F. / Arrowsmith, C.H. / Weigelt, J. / Edwards, ...Authors: Chaikuad, A. / Guo, K. / Cooper, C.D.O. / Ayinampudi, V. / Krojer, T. / Ugochukwu, E. / Muniz, J.R.C. / Vollmar, M. / Canning, P. / von Delft, F. / Arrowsmith, C.H. / Weigelt, J. / Edwards, A.M. / Bountra, C. / Bullock, A. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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-Validation report
Summary document | ![]() | 462.9 KB | Display | ![]() |
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Full document | ![]() | 469.6 KB | Display | |
Data in XML | ![]() | 28.8 KB | Display | |
Data in CIF | ![]() | 40.7 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 1fbvS S: Starting model for refinement |
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Similar structure data |
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Assembly
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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