Entry Database : PDB / ID : 3og7 Structure visualization Downloads & linksTitle B-Raf Kinase V600E oncogenic mutant in complex with PLX4032 ComponentsAKAP9-BRAF fusion protein Details Keywords transferase/transferase inhibitor / B-Raf / BRAF / PROTO-ONCOGENE / V600E / Kinase / TRANSFERASE / transferase-transferase inhibitor complexFunction / homology Function and homology informationFunction Domain/homology Component
CD4-positive, alpha-beta T cell differentiation / trehalose metabolism in response to stress / CD4-positive or CD8-positive, alpha-beta T cell lineage commitment / negative regulation of synaptic vesicle exocytosis / Signalling to p38 via RIT and RIN / head morphogenesis / myeloid progenitor cell differentiation / ARMS-mediated activation / SHOC2 M1731 mutant abolishes MRAS complex function / Gain-of-function MRAS complexes activate RAF signaling ... CD4-positive, alpha-beta T cell differentiation / trehalose metabolism in response to stress / CD4-positive or CD8-positive, alpha-beta T cell lineage commitment / negative regulation of synaptic vesicle exocytosis / Signalling to p38 via RIT and RIN / head morphogenesis / myeloid progenitor cell differentiation / ARMS-mediated activation / SHOC2 M1731 mutant abolishes MRAS complex function / Gain-of-function MRAS complexes activate RAF signaling / endothelial cell apoptotic process / negative regulation of fibroblast migration / positive regulation of glucose transmembrane transport / establishment of protein localization to membrane / mitogen-activated protein kinase kinase binding / microtubule organizing center / regulation of T cell differentiation / Negative feedback regulation of MAPK pathway / positive regulation of axonogenesis / Frs2-mediated activation / stress fiber assembly / positive regulation of axon regeneration / face development / synaptic vesicle exocytosis / somatic stem cell population maintenance / MAP kinase kinase activity / thyroid gland development / MAP kinase kinase kinase activity / negative regulation of endothelial cell apoptotic process / positive regulation of substrate adhesion-dependent cell spreading / positive regulation of stress fiber assembly / response to cAMP / cellular response to calcium ion / ERK1 and ERK2 cascade / substrate adhesion-dependent cell spreading / cellular response to nerve growth factor stimulus / thymus development / long-term synaptic potentiation / animal organ morphogenesis / RAF activation / Spry regulation of FGF signaling / Signaling by high-kinase activity BRAF mutants / MAP2K and MAPK activation / visual learning / epidermal growth factor receptor signaling pathway / response to peptide hormone / Negative regulation of MAPK pathway / Signaling by RAF1 mutants / Signaling by moderate kinase activity BRAF mutants / Paradoxical activation of RAF signaling by kinase inactive BRAF / Signaling downstream of RAS mutants / MAPK cascade / Signaling by BRAF and RAF1 fusions / cellular response to xenobiotic stimulus / presynapse / positive regulation of peptidyl-serine phosphorylation / T cell receptor signaling pathway / regulation of cell population proliferation / cell body / T cell differentiation in thymus / scaffold protein binding / negative regulation of neuron apoptotic process / Ras protein signal transduction / molecular adaptor activity / positive regulation of ERK1 and ERK2 cascade / non-specific serine/threonine protein kinase / protein kinase activity / neuron projection / protein phosphorylation / intracellular membrane-bounded organelle / protein serine kinase activity / protein serine/threonine kinase activity / calcium ion binding / protein-containing complex binding / positive regulation of gene expression / negative regulation of apoptotic process / signal transduction / mitochondrion / DNA binding / ATP binding / identical protein binding / nucleus / plasma membrane / cytoplasm / cytosol Similarity search - Function ELK domain / A-kinase anchor protein 9/Pericentrin / ELK / Raf-like Ras-binding domain / Raf-like Ras-binding / Ras-binding domain (RBD) profile. / Raf-like Ras-binding domain / Diacylglycerol/phorbol-ester binding / Phorbol esters/diacylglycerol binding domain (C1 domain) / Zinc finger phorbol-ester/DAG-type signature. ... ELK domain / A-kinase anchor protein 9/Pericentrin / ELK / Raf-like Ras-binding domain / Raf-like Ras-binding / Ras-binding domain (RBD) profile. / Raf-like Ras-binding domain / Diacylglycerol/phorbol-ester binding / Phorbol esters/diacylglycerol binding domain (C1 domain) / Zinc finger phorbol-ester/DAG-type signature. / Zinc finger phorbol-ester/DAG-type profile. / Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) / Protein kinase C-like, phorbol ester/diacylglycerol-binding domain / C1-like domain superfamily / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Ubiquitin-like domain superfamily / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.45 Å DetailsAuthors Zhang, Y. / Zhang, K.Y. / Zhang, C. CitationJournal : Nature / Year : 2010Title : Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma.Authors: Bollag, G. / Hirth, P. / Tsai, J. / Zhang, J. / Ibrahim, P.N. / Cho, H. / Spevak, W. / Zhang, C. / Zhang, Y. / Habets, G. / Burton, E.A. / Wong, B. / Tsang, G. / West, B.L. / Powell, B. / ... Authors : Bollag, G. / Hirth, P. / Tsai, J. / Zhang, J. / Ibrahim, P.N. / Cho, H. / Spevak, W. / Zhang, C. / Zhang, Y. / Habets, G. / Burton, E.A. / Wong, B. / Tsang, G. / West, B.L. / Powell, B. / Shellooe, R. / Marimuthu, A. / Nguyen, H. / Zhang, K.Y. / Artis, D.R. / Schlessinger, J. / Su, F. / Higgins, B. / Iyer, R. / D'Andrea, K. / Koehler, A. / Stumm, M. / Lin, P.S. / Lee, R.J. / Grippo, J. / Puzanov, I. / Kim, K.B. / Ribas, A. / McArthur, G.A. / Sosman, J.A. / Chapman, P.B. / Flaherty, K.T. / Xu, X. / Nathanson, K.L. / Nolop, K. History Deposition Aug 16, 2010 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Sep 22, 2010 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2011 Group : Version format complianceRevision 1.2 Oct 25, 2017 Group : Structure summary / Item : _chem_comp.pdbx_synonymsRevision 1.3 May 2, 2018 Group : Data collection / Structure summary / Category : struct_keywordsItem : _struct_keywords.pdbx_keywords / _struct_keywords.textRevision 1.4 Feb 21, 2024 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Structure summary Category : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / struct_ref_seq_dif / struct_site Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI ... _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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