Entry Database : PDB / ID : 3nyl Structure visualization Downloads & linksTitle The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain ComponentsAmyloid beta (A4) protein (Peptidase nexin-II, Alzheimer disease), isoform CRA_b Details Keywords CELL ADHESION / Alzheimer's disease / helical hairpinFunction / homology Function and homology informationFunction Domain/homology Component
tumor necrosis factor production / : / amylin binding / regulation of acetylcholine-gated cation channel activity / : / : / positive regulation of chemokine production => GO:0032722 / cellular process / : / : ... tumor necrosis factor production / : / amylin binding / regulation of acetylcholine-gated cation channel activity / : / : / positive regulation of chemokine production => GO:0032722 / cellular process / : / : / positive regulation of cell activation / positive regulation of tumor necrosis factor production => GO:0032760 / positive regulation of protein import / regulation of response to calcium ion / acetylcholine receptor activator activity / positive regulation of response to endoplasmic reticulum stress / amyloid-beta complex / positive regulation of G protein-coupled receptor internalization / growth cone lamellipodium / cellular response to norepinephrine stimulus / : / protein metabolic process => GO:0019538 / growth cone filopodium / : / : / endosome to plasma membrane transport vesicle / : / regulation of dendritic spine maintenance / negative regulation of blood circulation / lipoprotein particle / intermediate-density lipoprotein particle / positive regulation of endothelin production / regulation of amyloid-beta clearance / protein trimerization / positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process / : / platelet degranulation / regulation of amyloid fibril formation / response to yeast / peptidase activator activity / growth factor receptor binding / RAGE receptor binding / positive regulation of G protein-coupled receptor signaling pathway / lipoprotein metabolic process / high-density lipoprotein particle / astrocyte projection / antifungal humoral response / heparan sulfate proteoglycan binding / heparan sulfate binding / regulation of epidermal growth factor-activated receptor activity / : / positive regulation of membrane protein ectodomain proteolysis / frizzled binding / signaling receptor activator activity / cytosolic mRNA polyadenylation / collateral sprouting in absence of injury / microglia development / regulation of synapse structure or activity / Formyl peptide receptors bind formyl peptides and many other ligands / axo-dendritic transport / acetylcholine receptor binding / synaptic assembly at neuromuscular junction / smooth endoplasmic reticulum calcium ion homeostasis / axon midline choice point recognition / astrocyte activation involved in immune response / positive regulation of monocyte chemotaxis / regulation of spontaneous synaptic transmission / regulation of Wnt signaling pathway / negative regulation of protein localization to nucleus / mating behavior / positive regulation of amyloid fibril formation / low-density lipoprotein particle receptor binding / ciliary rootlet / main axon / Lysosome Vesicle Biogenesis / PTB domain binding / positive regulation of tau-protein kinase activity / Golgi-associated vesicle / neuron remodeling / Insertion of tail-anchored proteins into the endoplasmic reticulum membrane / : / positive regulation of amyloid-beta formation / Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models / presynaptic active zone / nuclear envelope lumen / regulation of toll-like receptor signaling pathway / modulation of excitatory postsynaptic potential / suckling behavior / COPII-coated ER to Golgi transport vesicle / dendrite development / chemoattractant activity / smooth endoplasmic reticulum / positive regulation of protein kinase A signaling / plasma membrane => GO:0005886 / regulation of NMDA receptor activity / apolipoprotein binding / TRAF6 mediated NF-kB activation / negative regulation of long-term synaptic potentiation / positive regulation of excitatory postsynaptic potential / associative learning Similarity search - Function Amyloid-beta precursor protein / Amyloid precursor protein, E2 domain / Amyloidogenic glycoprotein, copper-binding / Amyloidogenic glycoprotein, copper-binding domain conserved site / Amyloidogenic glycoprotein, copper-binding domain superfamily / Copper-binding of amyloid precursor, CuBD / Amyloid precursor protein (APP) copper-binding (CuBD) domain signature. / Amyloidogenic glycoprotein, amyloid-beta peptide superfamily / Beta-amyloid peptide (beta-APP) / Amyloidogenic glycoprotein, amyloid-beta peptide ... Amyloid-beta precursor protein / Amyloid precursor protein, E2 domain / Amyloidogenic glycoprotein, copper-binding / Amyloidogenic glycoprotein, copper-binding domain conserved site / Amyloidogenic glycoprotein, copper-binding domain superfamily / Copper-binding of amyloid precursor, CuBD / Amyloid precursor protein (APP) copper-binding (CuBD) domain signature. / Amyloidogenic glycoprotein, amyloid-beta peptide superfamily / Beta-amyloid peptide (beta-APP) / Amyloidogenic glycoprotein, amyloid-beta peptide / Beta-amyloid precursor protein C-terminal / Amyloidogenic glycoprotein, intracellular domain, conserved site / Beta-amyloid precursor protein C-terminus / Amyloid precursor protein (APP) intracellular domain signature. / Amyloid precursor protein (APP) E1 domain profile. / Amyloid precursor protein (APP) E2 domain profile. / Amyloidogenic glycoprotein, extracellular / Amyloidogenic glycoprotein, heparin-binding / Amyloidogenic glycoprotein, E2 domain / E2 domain superfamily / Amyloidogenic glycoprotein, heparin-binding domain superfamily / Amyloid A4 N-terminal heparin-binding / E2 domain of amyloid precursor protein / amyloid A4 / Amyloidogenic glycoprotein / Proteinase inhibitor I2, Kunitz, conserved site / Pancreatic trypsin inhibitor (Kunitz) family signature. / BPTI/Kunitz family of serine protease inhibitors. / Pancreatic trypsin inhibitor Kunitz domain / Kunitz/Bovine pancreatic trypsin inhibitor domain / Pancreatic trypsin inhibitor (Kunitz) family profile. / Pancreatic trypsin inhibitor Kunitz domain superfamily / Four Helix Bundle (Hemerythrin (Met), subunit A) / PH-like domain superfamily / Up-down Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MAD / Resolution : 2.8 Å DetailsAuthors Ha, Y. / Hu, J. / Lee, S. / Liu, X. / Wang, Y. CitationJournal : Mol.Cell / Year : 2004Title : The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain.Authors : Wang, Y. / Ha, Y. History Deposition Jul 15, 2010 Deposition site : RCSB / Processing site : RCSBSupersession Jul 13, 2011 ID : 1RW6 Revision 1.0 Jul 13, 2011 Provider : repository / Type : Initial releaseRevision 1.1 Feb 21, 2024 Group : Data collection / Database referencesCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / struct_ref_seq_dif Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details
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