Entry Database : PDB / ID : 3nyl Structure visualization Downloads & linksTitle The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain ComponentsAmyloid beta (A4) protein (Peptidase nexin-II, Alzheimer disease), isoform CRA_b Details Keywords CELL ADHESION / Alzheimer's disease / helical hairpinFunction / homology Function and homology informationFunction Domain/homology Component
tumor necrosis factor production / : / amylin binding / regulation of acetylcholine-gated cation channel activity / positive regulation of protein import / : / : / positive regulation of chemokine production => GO:0032722 / cellular process / : ... tumor necrosis factor production / : / amylin binding / regulation of acetylcholine-gated cation channel activity / positive regulation of protein import / : / : / positive regulation of chemokine production => GO:0032722 / cellular process / : / positive regulation of response to endoplasmic reticulum stress / : / positive regulation of cell activation / amyloid-beta complex / positive regulation of tumor necrosis factor production => GO:0032760 / positive regulation of G protein-coupled receptor internalization / : / regulation of response to calcium ion / acetylcholine receptor activator activity / growth cone lamellipodium / endosome to plasma membrane transport vesicle / cellular response to norepinephrine stimulus / : / protein metabolic process => GO:0019538 / growth cone filopodium / : / : / regulation of dendritic spine maintenance / negative regulation of blood circulation / : / positive regulation of endothelin production / positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process / protein trimerization / : / platelet degranulation / response to yeast / lipoprotein particle / regulation of amyloid-beta clearance / intermediate-density lipoprotein particle / peptidase activator activity / growth factor receptor binding / positive regulation of G protein-coupled receptor signaling pathway / RAGE receptor binding / lipoprotein metabolic process / regulation of amyloid fibril formation / antifungal humoral response / astrocyte projection / regulation of epidermal growth factor-activated receptor activity / heparan sulfate binding / frizzled binding / cytosolic mRNA polyadenylation / collateral sprouting in absence of injury / high-density lipoprotein particle / microglia development / regulation of synapse structure or activity / regulation of Wnt signaling pathway / acetylcholine receptor binding / Formyl peptide receptors bind formyl peptides and many other ligands / axo-dendritic transport / synaptic assembly at neuromuscular junction / signaling receptor activator activity / heparan sulfate proteoglycan binding / positive regulation of monocyte chemotaxis / smooth endoplasmic reticulum calcium ion homeostasis / axon midline choice point recognition / negative regulation of protein localization to nucleus / astrocyte activation involved in immune response / regulation of NMDA receptor activity / positive regulation of membrane protein ectodomain proteolysis / regulation of spontaneous synaptic transmission / mating behavior / NMDA selective glutamate receptor signaling pathway / ciliary rootlet / Lysosome Vesicle Biogenesis / PTB domain binding / positive regulation of tau-protein kinase activity / main axon / Golgi-associated vesicle / positive regulation of amyloid fibril formation / neuron remodeling / : / Insertion of tail-anchored proteins into the endoplasmic reticulum membrane / low-density lipoprotein particle receptor binding / positive regulation of amyloid-beta formation / Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models / regulation of toll-like receptor signaling pathway / suckling behavior / nuclear envelope lumen / dendrite development / COPII-coated ER to Golgi transport vesicle / chemoattractant activity / presynaptic active zone / positive regulation of protein kinase A signaling / plasma membrane => GO:0005886 / modulation of excitatory postsynaptic potential / associative learning / positive regulation of excitatory postsynaptic potential / positive regulation of cysteine-type endopeptidase activity involved in apoptotic process / apolipoprotein binding / TRAF6 mediated NF-kB activation Similarity search - Function Amyloid-beta precursor protein / Amyloid precursor protein, E2 domain / Amyloidogenic glycoprotein, copper-binding / Amyloidogenic glycoprotein, copper-binding domain conserved site / Amyloidogenic glycoprotein, copper-binding domain superfamily / Copper-binding of amyloid precursor, CuBD / Amyloid precursor protein (APP) copper-binding (CuBD) domain signature. / Amyloidogenic glycoprotein, amyloid-beta peptide superfamily / Beta-amyloid peptide (beta-APP) / Amyloidogenic glycoprotein, amyloid-beta peptide ... Amyloid-beta precursor protein / Amyloid precursor protein, E2 domain / Amyloidogenic glycoprotein, copper-binding / Amyloidogenic glycoprotein, copper-binding domain conserved site / Amyloidogenic glycoprotein, copper-binding domain superfamily / Copper-binding of amyloid precursor, CuBD / Amyloid precursor protein (APP) copper-binding (CuBD) domain signature. / Amyloidogenic glycoprotein, amyloid-beta peptide superfamily / Beta-amyloid peptide (beta-APP) / Amyloidogenic glycoprotein, amyloid-beta peptide / Beta-amyloid precursor protein C-terminal / Amyloidogenic glycoprotein, intracellular domain, conserved site / Beta-amyloid precursor protein C-terminus / Amyloid precursor protein (APP) intracellular domain signature. / Amyloid precursor protein (APP) E1 domain profile. / Amyloid precursor protein (APP) E2 domain profile. / Amyloidogenic glycoprotein, extracellular / Amyloidogenic glycoprotein, heparin-binding / Amyloidogenic glycoprotein, E2 domain / E2 domain superfamily / Amyloidogenic glycoprotein, heparin-binding domain superfamily / Amyloid A4 N-terminal heparin-binding / E2 domain of amyloid precursor protein / amyloid A4 / Amyloidogenic glycoprotein / Proteinase inhibitor I2, Kunitz, conserved site / Pancreatic trypsin inhibitor (Kunitz) family signature. / BPTI/Kunitz family of serine protease inhibitors. / Pancreatic trypsin inhibitor Kunitz domain / Kunitz/Bovine pancreatic trypsin inhibitor domain / Pancreatic trypsin inhibitor (Kunitz) family profile. / Pancreatic trypsin inhibitor Kunitz domain superfamily / Four Helix Bundle (Hemerythrin (Met), subunit A) / PH-like domain superfamily / Up-down Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MAD / Resolution : 2.8 Å DetailsAuthors Ha, Y. / Hu, J. / Lee, S. / Liu, X. / Wang, Y. CitationJournal : Mol.Cell / Year : 2004Title : The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain.Authors : Wang, Y. / Ha, Y. History Deposition Jul 15, 2010 Deposition site : RCSB / Processing site : RCSBSupersession Jul 13, 2011 ID : 1RW6 Revision 1.0 Jul 13, 2011 Provider : repository / Type : Initial releaseRevision 1.1 Feb 21, 2024 Group : Data collection / Database referencesCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / struct_ref_seq_dif Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details
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