Entry Database : PDB / ID : 3mxc Structure visualization Downloads & linksTitle Structures of Grb2-SH2 Domain and AICD peptide Complexes Reveal a Conformational Switch and Their Functional Implications. ComponentsAICD peptide Growth factor receptor-bound protein 2 DetailsKeywords PROTEIN BINDING / Protein-peptide complex / AICD / Grb2-SH2 / ALZHEIMER'S DISEASE / APPFunction / homology Function and homology informationFunction Domain/homology Component
guanyl-nucleotide exchange factor adaptor activity / Grb2-EGFR complex / branching involved in labyrinthine layer morphogenesis / STAT5 Activation / COP9 signalosome / neurotrophin TRKA receptor binding / Activated NTRK2 signals through PI3K / vesicle membrane / regulation of epidermal growth factor-activated receptor activity / MET receptor recycling ... guanyl-nucleotide exchange factor adaptor activity / Grb2-EGFR complex / branching involved in labyrinthine layer morphogenesis / STAT5 Activation / COP9 signalosome / neurotrophin TRKA receptor binding / Activated NTRK2 signals through PI3K / vesicle membrane / regulation of epidermal growth factor-activated receptor activity / MET receptor recycling / cytosolic mRNA polyadenylation / collateral sprouting in absence of injury / transmembrane receptor protein tyrosine kinase adaptor activity / microglia development / regulation of synapse structure or activity / Signaling by cytosolic FGFR1 fusion mutants / regulation of Wnt signaling pathway / Formyl peptide receptors bind formyl peptides and many other ligands / axo-dendritic transport / synaptic assembly at neuromuscular junction / signaling receptor activator activity / Interleukin-15 signaling / smooth endoplasmic reticulum calcium ion homeostasis / axon midline choice point recognition / MET activates PTPN11 / astrocyte activation involved in immune response / regulation of spontaneous synaptic transmission / mating behavior / MET activates RAP1 and RAC1 / NMDA selective glutamate receptor signaling pathway / Costimulation by the CD28 family / CD28 dependent Vav1 pathway / MET activates PI3K/AKT signaling / ciliary rootlet / Signal regulatory protein family interactions / Lysosome Vesicle Biogenesis / PTB domain binding / Golgi-associated vesicle / positive regulation of amyloid fibril formation / neuron remodeling / : / Insertion of tail-anchored proteins into the endoplasmic reticulum membrane / Regulation of KIT signaling / epidermal growth factor receptor binding / Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models / positive regulation of actin filament polymerization / PI-3K cascade:FGFR3 / suckling behavior / STAT5 activation downstream of FLT3 ITD mutants / nuclear envelope lumen / PI-3K cascade:FGFR2 / PI-3K cascade:FGFR4 / dendrite development / COPII-coated ER to Golgi transport vesicle / PI-3K cascade:FGFR1 / endodermal cell differentiation / presynaptic active zone / modulation of excitatory postsynaptic potential / TRAF6 mediated NF-kB activation / regulation of MAPK cascade / GRB2:SOS provides linkage to MAPK signaling for Integrins / Advanced glycosylation endproduct receptor signaling / RHOU GTPase cycle / neuromuscular process controlling balance / The NLRP3 inflammasome / PI3K events in ERBB2 signaling / regulation of presynapse assembly / transition metal ion binding / SOS-mediated signalling / RET signaling / Activated NTRK3 signals through RAS / negative regulation of long-term synaptic potentiation / Activated NTRK2 signals through RAS / regulation of multicellular organism growth / insulin receptor substrate binding / Interleukin-3, Interleukin-5 and GM-CSF signaling / intracellular copper ion homeostasis / negative regulation of neuron differentiation / PI3K Cascade / SHC1 events in ERBB4 signaling / ECM proteoglycans / smooth endoplasmic reticulum / Signalling to RAS / RHO GTPases Activate WASPs and WAVEs / positive regulation of T cell migration / fibroblast growth factor receptor signaling pathway / signal transduction in response to DNA damage / spindle midzone / SHC-related events triggered by IGF1R / GAB1 signalosome / Activated NTRK2 signals through FRS2 and FRS3 / Role of LAT2/NTAL/LAB on calcium mobilization / Signal attenuation / Interleukin receptor SHC signaling / SHC-mediated cascade:FGFR3 / MET activates RAS signaling / Schwann cell development / Purinergic signaling in leishmaniasis infection / Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants / Signaling by PDGFRA extracellular domain mutants Similarity search - Function GRB2, N-terminal SH3 domain / GRB2, C-terminal SH3 domain / Grb2-like / Amyloidogenic glycoprotein, copper-binding / Amyloidogenic glycoprotein, copper-binding domain conserved site / Amyloidogenic glycoprotein, copper-binding domain superfamily / Copper-binding of amyloid precursor, CuBD / Amyloid precursor protein (APP) copper-binding (CuBD) domain signature. / Amyloidogenic glycoprotein, amyloid-beta peptide superfamily / Beta-amyloid peptide (beta-APP) ... GRB2, N-terminal SH3 domain / GRB2, C-terminal SH3 domain / Grb2-like / Amyloidogenic glycoprotein, copper-binding / Amyloidogenic glycoprotein, copper-binding domain conserved site / Amyloidogenic glycoprotein, copper-binding domain superfamily / Copper-binding of amyloid precursor, CuBD / Amyloid precursor protein (APP) copper-binding (CuBD) domain signature. / Amyloidogenic glycoprotein, amyloid-beta peptide superfamily / Beta-amyloid peptide (beta-APP) / Amyloidogenic glycoprotein, amyloid-beta peptide / Beta-amyloid precursor protein C-terminal / Amyloidogenic glycoprotein, intracellular domain, conserved site / Beta-amyloid precursor protein C-terminus / Amyloid precursor protein (APP) intracellular domain signature. / Amyloid precursor protein (APP) E1 domain profile. / Amyloid precursor protein (APP) E2 domain profile. / Amyloidogenic glycoprotein, extracellular / Amyloidogenic glycoprotein, heparin-binding / Amyloidogenic glycoprotein, E2 domain / E2 domain superfamily / Amyloidogenic glycoprotein, heparin-binding domain superfamily / Amyloid A4 N-terminal heparin-binding / E2 domain of amyloid precursor protein / amyloid A4 / Amyloidogenic glycoprotein / SH2 domain / SHC Adaptor Protein / Proteinase inhibitor I2, Kunitz, conserved site / Pancreatic trypsin inhibitor (Kunitz) family signature. / BPTI/Kunitz family of serine protease inhibitors. / Pancreatic trypsin inhibitor Kunitz domain / Kunitz/Bovine pancreatic trypsin inhibitor domain / Pancreatic trypsin inhibitor (Kunitz) family profile. / Pancreatic trypsin inhibitor Kunitz domain superfamily / SH3 domain / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / Src homology 3 domains / SH2 domain superfamily / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / PH-like domain superfamily / 2-Layer Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution : 2 Å DetailsAuthors Sen, U. / Das, S. CitationJournal : J.Mol.Biol. / Year : 2011Title : Functional Implications of the Conformational Switch in AICD Peptide upon Binding to Grb2-SH2 Domain.Authors : Das, S. / Raychaudhuri, M. / Sen, U. / Mukhopadhyay, D. History Deposition May 7, 2010 Deposition site : RCSB / Processing site : RCSBRevision 1.0 May 11, 2011 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2011 Group : Version format complianceRevision 1.2 Oct 12, 2011 Group : Database referencesRevision 1.3 Nov 2, 2011 Group : Database referencesRevision 1.4 Dec 14, 2011 Group : Database referencesRevision 1.5 Sep 6, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn / struct_ref_seq_dif Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_ref_seq_dif.details Revision 1.6 Nov 22, 2023 Group : Data collection / Category : chem_comp_atom / chem_comp_bond / Item : _chem_comp_atom.atom_id / _chem_comp_bond.atom_id_2
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