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Open data
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Basic information
Entry | Database: PDB / ID: 3m8p | ||||||
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Title | HIV-1 RT with NNRTI TMC-125 | ||||||
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![]() | TRANSFERASE / HIV / RT / REVERSE TRANSCRIPTASE RIBONUCLEASE H / TRANSFERASE RNA-DIRECTED DNA POLYMERASE / NUCLEOTIDYLTRANSFERASE / Hydrolase | ||||||
Function / homology | ![]() integrase activity / Integration of viral DNA into host genomic DNA / Autointegration results in viral DNA circles / Minus-strand DNA synthesis / Plus-strand DNA synthesis / 2-LTR circle formation / Uncoating of the HIV Virion / Vpr-mediated nuclear import of PICs / Early Phase of HIV Life Cycle / Integration of provirus ...integrase activity / Integration of viral DNA into host genomic DNA / Autointegration results in viral DNA circles / Minus-strand DNA synthesis / Plus-strand DNA synthesis / 2-LTR circle formation / Uncoating of the HIV Virion / Vpr-mediated nuclear import of PICs / Early Phase of HIV Life Cycle / Integration of provirus / APOBEC3G mediated resistance to HIV-1 infection / Binding and entry of HIV virion / viral life cycle / Assembly Of The HIV Virion / HIV-1 retropepsin / retroviral ribonuclease H / exoribonuclease H / Budding and maturation of HIV virion / exoribonuclease H activity / protein processing / host multivesicular body / viral genome integration into host DNA / RNA-directed DNA polymerase / establishment of integrated proviral latency / viral penetration into host nucleus / RNA stem-loop binding / RNA-directed DNA polymerase activity / host cell / RNA-DNA hybrid ribonuclease activity / Transferases; Transferring phosphorus-containing groups; Nucleotidyltransferases / peptidase activity / symbiont-mediated suppression of host gene expression / viral nucleocapsid / DNA recombination / DNA-directed DNA polymerase / Hydrolases; Acting on ester bonds / aspartic-type endopeptidase activity / DNA-directed DNA polymerase activity / symbiont entry into host cell / lipid binding / host cell nucleus / host cell plasma membrane / structural molecule activity / virion membrane / DNA binding / zinc ion binding / identical protein binding / membrane Similarity search - Function | ||||||
Biological species | ![]() ![]() | ||||||
Method | ![]() ![]() ![]() | ||||||
![]() | Harris, S.F. / Villasenor, A. | ||||||
![]() | ![]() Title: Discovery of piperidin-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-benzyl derivatives with broad potency against resistant mutant viruses. Authors: Kertesz, D.J. / Brotherton-Pleiss, C. / Yang, M. / Wang, Z. / Lin, X. / Qiu, Z. / Hirschfeld, D.R. / Gleason, S. / Mirzadegan, T. / Dunten, P.W. / Harris, S.F. / Villasenor, A.G. / Hang, J.Q. ...Authors: Kertesz, D.J. / Brotherton-Pleiss, C. / Yang, M. / Wang, Z. / Lin, X. / Qiu, Z. / Hirschfeld, D.R. / Gleason, S. / Mirzadegan, T. / Dunten, P.W. / Harris, S.F. / Villasenor, A.G. / Hang, J.Q. / Heilek, G.M. / Klumpp, K. | ||||||
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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PDBx/mmCIF format | ![]() | 211.3 KB | Display | ![]() |
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PDB format | ![]() | 167.5 KB | Display | ![]() |
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-Validation report
Summary document | ![]() | 742.9 KB | Display | ![]() |
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Full document | ![]() | 773.3 KB | Display | |
Data in XML | ![]() | 41.1 KB | Display | |
Data in CIF | ![]() | 57.7 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
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Assembly
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Components
#1: Protein | Mass: 64710.121 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() ![]() References: UniProt: P04585, RNA-directed DNA polymerase, DNA-directed DNA polymerase, |
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