登録情報 データベース : PDB / ID : 3ixe 構造の表示 ダウンロードとリンクタイトル Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase 要素Integrin-linked protein kinase LIM and senescent cell antigen-like-containing domain protein 2 詳細キーワード SIGNALING PROTEIN/SIGNALING PROTEIN / ILK / INTEGRIN-LINKED KINASE / PINCH / LIM / ANKYRIN REPEAT / ANK / IPP / INTEGRIN-MEDIATED SIGNALING / ANK REPEAT / LIM DOMAIN / ZINC / ATP-binding / Cell junction / Cell membrane / Kinase / Membrane / Nucleotide-binding / Phosphoprotein / Serine/threonine-protein kinase / Transferase / Alternative splicing / Metal-binding / Nucleus / SIGNALING PROTEIN-SIGNALING PROTEIN COMPLEX機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
negative regulation of hepatocyte proliferation / Localization of the PINCH-ILK-PARVIN complex to focal adhesions / negative regulation of neural precursor cell proliferation / positive regulation of signal transduction / positive regulation of integrin-mediated signaling pathway / nerve development / Cell-extracellular matrix interactions / fibroblast migration / myelination in peripheral nervous system / cell projection organization ... negative regulation of hepatocyte proliferation / Localization of the PINCH-ILK-PARVIN complex to focal adhesions / negative regulation of neural precursor cell proliferation / positive regulation of signal transduction / positive regulation of integrin-mediated signaling pathway / nerve development / Cell-extracellular matrix interactions / fibroblast migration / myelination in peripheral nervous system / cell projection organization / cell junction assembly / cell-cell junction organization / positive regulation of BMP signaling pathway / neural precursor cell proliferation / establishment or maintenance of epithelial cell apical/basal polarity / branching involved in ureteric bud morphogenesis / outflow tract morphogenesis / positive regulation of osteoblast differentiation / positive regulation of substrate adhesion-dependent cell spreading / positive regulation of phosphorylation / tumor necrosis factor-mediated signaling pathway / sarcomere / phosphatidylinositol 3-kinase/protein kinase B signal transduction / substrate adhesion-dependent cell spreading / cell-matrix adhesion / integrin-mediated signaling pathway / cell morphogenesis / platelet aggregation / cell-cell adhesion / cell-cell junction / positive regulation of canonical Wnt signaling pathway / lamellipodium / positive regulation of canonical NF-kappaB signal transduction / non-specific serine/threonine protein kinase / positive regulation of protein phosphorylation / protein phosphorylation / focal adhesion / protein serine kinase activity / protein serine/threonine kinase activity / positive regulation of cell population proliferation / negative regulation of apoptotic process / protein kinase binding / positive regulation of DNA-templated transcription / ATP binding / membrane / nucleus / metal ion binding / plasma membrane / cytoplasm / cytosol 類似検索 - 分子機能 LIM and senescent cell antigen-like-containing domain protein 1-like / Integrin-linked protein kinase, pseudokinase domain / Cysteine Rich Protein / Cysteine Rich Protein / LIM zinc-binding domain signature. / LIM domain / Zinc-binding domain present in Lin-11, Isl-1, Mec-3. / Zinc finger, LIM-type / LIM domain profile. / Ankyrin repeat-containing domain ... LIM and senescent cell antigen-like-containing domain protein 1-like / Integrin-linked protein kinase, pseudokinase domain / Cysteine Rich Protein / Cysteine Rich Protein / LIM zinc-binding domain signature. / LIM domain / Zinc-binding domain present in Lin-11, Isl-1, Mec-3. / Zinc finger, LIM-type / LIM domain profile. / Ankyrin repeat-containing domain / Ankyrin repeats (3 copies) / Ankyrin repeat profile. / Ankyrin repeat region circular profile. / ankyrin repeats / Ankyrin repeat / Ankyrin repeat-containing domain superfamily / Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat / Ribbon / Alpha Horseshoe / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Mainly Beta / Mainly Alpha 類似検索 - ドメイン・相同性 Integrin-linked protein kinase / LIM and senescent cell antigen-like-containing domain protein 2 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.9 Å 詳細データ登録者 Chiswell, B.P. / Stiegler, A.L. / Boggon, T.J. / Calderwood, D.A. 引用ジャーナル : J.Struct.Biol. / 年 : 2010タイトル : Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase.著者 : Chiswell, B.P. / Stiegler, A.L. / Razinia, Z. / Nalibotski, E. / Boggon, T.J. / Calderwood, D.A. 履歴 登録 2009年9月3日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2009年12月15日 Provider : repository / タイプ : Initial release改定 1.1 2011年7月13日 Group : Version format compliance改定 1.2 2023年9月6日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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