登録情報 | データベース: PDB / ID: 3hng |
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タイトル | Crystal structure of VEGFR1 in complex with N-(4-Chlorophenyl)-2-((pyridin-4-ylmethyl)amino)benzamide |
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要素 | Vascular endothelial growth factor receptor 1 血管内皮細胞増殖因子受容体 |
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キーワード | TRANSFERASE (転移酵素) / RECEPTOR TYROSINE KINASE (受容体型チロシンキナーゼ) / VEGFR1 / FLT1 / KINASE DOMAIN (キナーゼ) / INHIBITOR (酵素阻害剤) / ACTIVATION LOOP (天然変性タンパク質) / VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR (血管内皮細胞増殖因子受容体) / STRUCTURAL GENOMICS (構造ゲノミクス) / STRUCTURAL GENOMICS CONSORTIUM / SGC / SGC STOCKHOLM / Angiogenesis (血管新生) / ATP-binding / Cell membrane (細胞膜) / Developmental protein (ヒトの発達) / Differentiation / Disulfide bond (ジスルフィド) / Glycoprotein (糖タンパク質) / Immunoglobulin domain (免疫グロブリンフォールド) / Kinase (キナーゼ) / Membrane (生体膜) / Nucleotide-binding / Phosphoprotein / Receptor / Secreted (分泌) / Transmembrane (膜貫通型タンパク質) / Tyrosine-protein kinase |
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機能・相同性 | 機能・相同性情報
vascular endothelial growth factor receptor-1 signaling pathway / placental growth factor receptor activity / hyaloid vascular plexus regression / Neurophilin interactions with VEGF and VEGFR / VEGF binds to VEGFR leading to receptor dimerization / vascular endothelial growth factor receptor activity / embryonic morphogenesis / negative regulation of vascular endothelial cell proliferation / blood vessel morphogenesis / growth factor binding ...vascular endothelial growth factor receptor-1 signaling pathway / placental growth factor receptor activity / hyaloid vascular plexus regression / Neurophilin interactions with VEGF and VEGFR / VEGF binds to VEGFR leading to receptor dimerization / vascular endothelial growth factor receptor activity / embryonic morphogenesis / negative regulation of vascular endothelial cell proliferation / blood vessel morphogenesis / growth factor binding / monocyte chemotaxis / cellular response to vascular endothelial growth factor stimulus / vascular endothelial growth factor receptor signaling pathway / : / transmembrane receptor protein tyrosine kinase activity / cell surface receptor protein tyrosine kinase signaling pathway / positive regulation of MAP kinase activity / 受容体型チロシンキナーゼ / peptidyl-tyrosine phosphorylation / positive regulation of angiogenesis / 遊走 / マイクロフィラメント / 血管新生 / positive regulation of MAPK cascade / protein autophosphorylation / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / 細胞分化 / receptor complex / エンドソーム / positive regulation of cell migration / focal adhesion / positive regulation of cell population proliferation / extracellular space / ATP binding / 細胞膜類似検索 - 分子機能 Vascular endothelial growth factor receptor 1 (VEGFR1) / VEGFR-2, transmembrane domain / VEGFR-2 Transmembrane domain / Vascular endothelial growth factor receptor 1-like, Ig-like domain / Tyrosine-protein kinase, receptor class III, conserved site / Receptor tyrosine kinase class III signature. / 抗体 / 免疫グロブリンフォールド / 免疫グロブリンフォールド / Immunoglobulin I-set ...Vascular endothelial growth factor receptor 1 (VEGFR1) / VEGFR-2, transmembrane domain / VEGFR-2 Transmembrane domain / Vascular endothelial growth factor receptor 1-like, Ig-like domain / Tyrosine-protein kinase, receptor class III, conserved site / Receptor tyrosine kinase class III signature. / 抗体 / 免疫グロブリンフォールド / 免疫グロブリンフォールド / Immunoglobulin I-set / Immunoglobulin I-set domain / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Immunoglobulin V-Type / Immunoglobulin V-set domain / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Immunoglobulin subtype / 抗体 / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Immunoglobulin-like fold / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 Chem-8ST / Vascular endothelial growth factor receptor 1類似検索 - 構成要素 |
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生物種 | ![](img/tx_human.gif) Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.7 Å |
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データ登録者 | Tresaugues, L. / Roos, A. / Arrowsmith, C.H. / Berglund, H. / Bountra, C. / Collins, R. / Edwards, A.M. / Flodin, S. / Flores, A. / Graslund, S. ...Tresaugues, L. / Roos, A. / Arrowsmith, C.H. / Berglund, H. / Bountra, C. / Collins, R. / Edwards, A.M. / Flodin, S. / Flores, A. / Graslund, S. / Hammarstrom, M. / Johansson, A. / Johansson, I. / Karlberg, T. / Kotenyova, T. / Moche, M. / Nyman, T. / Persson, C. / Kragh-Nielsen, T. / Kotzch, A. / Sagemark, J. / Schueler, H. / Schutz, P. / Siponen, M.I. / Svensson, L. / Thorsell, A.G. / Van der Berg, S. / Weigelt, J. / Welin, M. / Wisniewska, M. / Nordlund, P. / Structural Genomics Consortium (SGC) |
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引用 | ジャーナル: To be Published タイトル: Crystal structure of VEGFR1 in complex with N-(4-Chlorophenyl)-2-((pyridin-4-ylmethyl)amino)benzamide 著者: Tresaugues, L. / Roos, A. / Arrowsmith, C.H. / Berglund, H. / Bountra, C. / Collins, R. / Edwards, A.M. / Flodin, S. / Flores, A. / Graslund, S. / Hammarstrom, M. / Johansson, A. / Johansson, ...著者: Tresaugues, L. / Roos, A. / Arrowsmith, C.H. / Berglund, H. / Bountra, C. / Collins, R. / Edwards, A.M. / Flodin, S. / Flores, A. / Graslund, S. / Hammarstrom, M. / Johansson, A. / Johansson, I. / Karlberg, T. / Kotenyova, T. / Moche, M. / Nyman, T. / Persson, C. / Kragh-Nielsen, T. / Kotzch, A. / Sagemark, J. / Schueler, H. / Schutz, P. / Siponen, M.I. / Svensson, L. / Thorsell, A.G. / Van der Berg, S. / Weigelt, J. / Welin, M. / Wisniewska, M. / Nordlund, P. |
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履歴 | 登録 | 2009年5月31日 | 登録サイト: RCSB / 処理サイト: PDBJ |
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改定 1.0 | 2009年6月30日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Advisory / Refinement description / Version format compliance |
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改定 1.2 | 2023年11月1日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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