登録情報 | データベース: PDB / ID: 3gl6 |
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タイトル | Crystal structure of JARID1A-PHD3 complexed with H3(1-9)K4me3 peptide |
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要素 | - Histone H3
- Histone demethylase JARID1A
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キーワード | OXIDOREDUCTASE / PHD finger / H3(1-9)K4me3 peptide / leukemia / Alternative splicing / Chromatin regulator / Developmental protein / Dioxygenase / Iron / Metal-binding / Nucleus / Phosphoprotein / Polymorphism / Transcription / Transcription regulation / Zinc / Zinc-finger / Chromosomal protein / DNA-binding / Nucleosome core |
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機能・相同性 | 機能・相同性情報
facultative heterochromatin formation / [histone H3]-trimethyl-L-lysine4 demethylase / histone H3K4me/H3K4me2/H3K4me3 demethylase activity / regulation of DNA-binding transcription factor activity / enzyme inhibitor activity / histone demethylase activity / methylated histone binding / Chromatin modifications during the maternal to zygotic transition (MZT) / circadian regulation of gene expression / HDMs demethylate histones ...facultative heterochromatin formation / [histone H3]-trimethyl-L-lysine4 demethylase / histone H3K4me/H3K4me2/H3K4me3 demethylase activity / regulation of DNA-binding transcription factor activity / enzyme inhibitor activity / histone demethylase activity / methylated histone binding / Chromatin modifications during the maternal to zygotic transition (MZT) / circadian regulation of gene expression / HDMs demethylate histones / chromatin DNA binding / structural constituent of chromatin / nucleosome / histone binding / transcription coactivator activity / transcription cis-regulatory region binding / chromatin remodeling / protein heterodimerization activity / regulation of DNA-templated transcription / chromatin / nucleolus / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / DNA binding / zinc ion binding / nucleoplasm / nucleus類似検索 - 分子機能 : / : / : / : / : / Lysine-specific demethylase 5, C-terminal helical domain / Lysine-specific demethylase-like domain / PLU-1-like protein / Zinc finger, C5HC2-type / C5HC2 zinc finger ...: / : / : / : / : / Lysine-specific demethylase 5, C-terminal helical domain / Lysine-specific demethylase-like domain / PLU-1-like protein / Zinc finger, C5HC2-type / C5HC2 zinc finger / ARID/BRIGHT DNA binding domain / ARID DNA-binding domain / ARID DNA-binding domain superfamily / ARID/BRIGHT DNA binding domain / ARID domain profile. / BRIGHT, ARID (A/T-rich interaction domain) domain / JmjN domain / jmjN domain / JmjN domain profile. / Small domain found in the jumonji family of transcription factors / JmjC domain, hydroxylase / A domain family that is part of the cupin metalloenzyme superfamily. / JmjC domain / JmjC domain profile. / Zinc finger, PHD-type, conserved site / PHD-finger / Zinc finger PHD-type signature. / Zinc finger PHD-type profile. / Zinc finger, PHD-finger / Zinc finger, PHD-type / PHD zinc finger / Histone H3 signature 1. / Histone H3 signature 2. / Histone H3 / Histone H3/CENP-A / Histone H2A/H2B/H3 / Core histone H2A/H2B/H3/H4 / Zinc finger, FYVE/PHD-type / Histone-fold / Zinc finger, RING/FYVE/PHD-type類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.9 Å |
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データ登録者 | Wang, Z. / Song, J. / Patel, D.J. |
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引用 | ジャーナル: Nature / 年: 2009 タイトル: Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger. 著者: Wang, G.G. / Song, J. / Wang, Z. / Dormann, H.L. / Casadio, F. / Li, H. / Luo, J.L. / Patel, D.J. / Allis, C.D. |
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履歴 | 登録 | 2009年3月11日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2009年5月5日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Version format compliance |
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