登録情報 データベース : PDB / ID : 3g3n 構造の表示 ダウンロードとリンクタイトル PDE7A catalytic domain in complex with 3-(2,6-difluorophenyl)-2-(methylthio)quinazolin-4(3H)-one 要素High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A 詳細 キーワード HYDROLASE / pde7 / crystal / inhibitor complex / Alternative splicing / cAMP / Phosphoprotein機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
3',5'-cyclic-AMP phosphodiesterase / cAMP catabolic process / 3',5'-cyclic-GMP phosphodiesterase activity / 3',5'-cyclic-AMP phosphodiesterase activity / cAMP-mediated signaling / G alpha (s) signalling events / perinuclear region of cytoplasm / nucleus / metal ion binding / cytosol 類似検索 - 分子機能 Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain / 3'5'-cyclic nucleotide phosphodiesterase / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain / 3'5'-cyclic nucleotide phosphodiesterase, conserved site / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily / 3'5'-cyclic nucleotide phosphodiesterase / 3'5'-cyclic nucleotide phosphodiesterase domain signature. / 3'5'-cyclic nucleotide phosphodiesterase domain profile. / Metal dependent phosphohydrolases with conserved 'HD' motif. ... Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain / 3'5'-cyclic nucleotide phosphodiesterase / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain / 3'5'-cyclic nucleotide phosphodiesterase, conserved site / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily / 3'5'-cyclic nucleotide phosphodiesterase / 3'5'-cyclic nucleotide phosphodiesterase domain signature. / 3'5'-cyclic nucleotide phosphodiesterase domain profile. / Metal dependent phosphohydrolases with conserved 'HD' motif. / HD/PDEase domain / Orthogonal Bundle / Mainly Alpha 類似検索 - ドメイン・相同性 Chem-TC8 / High affinity 3',5'-cyclic-AMP phosphodiesterase 7A 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.4 Å 詳細データ登録者 Castano, T. / Wang, H. 引用ジャーナル : Chemmedchem / 年 : 2009タイトル : Synthesis, structural analysis, and biological evaluation of thioxoquinazoline derivatives as phosphodiesterase 7 inhibitors著者: Castano, T. / Wang, H. / Campillo, N.E. / Ballester, S. / Gonzalez-Garcia, C. / Hernandez, J. / Perez, C. / Cuenca, J. / Perez-Castillo, A. / Martinez, A. / Huertas, O. / Gelpi, J.L. / Luque, ... 著者 : Castano, T. / Wang, H. / Campillo, N.E. / Ballester, S. / Gonzalez-Garcia, C. / Hernandez, J. / Perez, C. / Cuenca, J. / Perez-Castillo, A. / Martinez, A. / Huertas, O. / Gelpi, J.L. / Luque, F.J. / Ke, H. / Gil, C. 履歴 登録 2009年2月2日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2009年4月28日 Provider : repository / タイプ : Initial release改定 1.1 2011年7月13日 Group : Version format compliance改定 1.2 2024年2月21日 Group : Data collection / Database references / Derived calculationsカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / struct_conn / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
すべて表示 表示を減らす