登録情報 | データベース: PDB / ID: 3f89 |
---|
タイトル | NEMO CoZi domain |
---|
要素 | NF-kappa-B essential modulator |
---|
キーワード | TRANSCRIPTION / NF-kB signaling / Ubiquitin binding / Coiled coil / Cytoplasm / Metal-binding / Nucleus / Phosphoprotein / Transcription regulation / Ubl conjugation / Zinc / Zinc-finger |
---|
機能・相同性 | 機能・相同性情報
IRAK1 recruits IKK complex / IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation / Regulation of NF-kappa B signaling / JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 / SUMOylation of immune response proteins / TNFR1-induced NF-kappa-B signaling pathway / IKK complex recruitment mediated by RIP1 / RIP-mediated NFkB activation via ZBP1 / Regulation of TNFR1 signaling / MAP3K8 (TPL2)-dependent MAPK1/3 activation ...IRAK1 recruits IKK complex / IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation / Regulation of NF-kappa B signaling / JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 / SUMOylation of immune response proteins / TNFR1-induced NF-kappa-B signaling pathway / IKK complex recruitment mediated by RIP1 / RIP-mediated NFkB activation via ZBP1 / Regulation of TNFR1 signaling / MAP3K8 (TPL2)-dependent MAPK1/3 activation / IkappaB kinase complex / TRAF6 mediated NF-kB activation / Ovarian tumor domain proteases / PKR-mediated signaling / linear polyubiquitin binding / Activation of NF-kappaB in B cells / TAK1-dependent IKK and NF-kappa-B activation / FCERI mediated NF-kB activation / CLEC7A (Dectin-1) signaling / Interleukin-1 signaling / Downstream TCR signaling / activated TAK1 mediates p38 MAPK activation / NOD1/2 Signaling Pathway / Ub-specific processing proteases / peroxisome proliferator activated receptor binding / anoikis / K63-linked polyubiquitin modification-dependent protein binding / positive regulation of T cell receptor signaling pathway / B cell homeostasis / positive regulation of macroautophagy / negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway / canonical NF-kappaB signal transduction / signaling adaptor activity / tumor necrosis factor-mediated signaling pathway / positive regulation of NF-kappaB transcription factor activity / positive regulation of canonical NF-kappaB signal transduction / protein heterodimerization activity / DNA damage response / positive regulation of gene expression / protein-containing complex binding / positive regulation of transcription by RNA polymerase II / protein homodimerization activity / identical protein binding / nucleus / metal ion binding / cytoplasm類似検索 - 分子機能 Nemo cc2-lz domain - 1d5 darpin complex / : / C2H2 type zinc-finger / NF-kappa-B essential modulator NEMO, N-terminal / NF-kappa-B essential modulator NEMO / NEMO, Zinc finger / Zinc finger CCHC NOA-type profile. / NF-kappa-B essential modulator NEMO, CC2-LZ domain / Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator / Single alpha-helices involved in coiled-coils or other helix-helix interfaces ...Nemo cc2-lz domain - 1d5 darpin complex / : / C2H2 type zinc-finger / NF-kappa-B essential modulator NEMO, N-terminal / NF-kappa-B essential modulator NEMO / NEMO, Zinc finger / Zinc finger CCHC NOA-type profile. / NF-kappa-B essential modulator NEMO, CC2-LZ domain / Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator / Single alpha-helices involved in coiled-coils or other helix-helix interfaces / Up-down Bundle / Mainly Alpha類似検索 - ドメイン・相同性 |
---|
生物種 | ![](img/tx_mammal.gif) Mus musculus (ハツカネズミ) |
---|
手法 | X線回折 / シンクロトロン / 単波長異常分散 / 解像度: 2.8 Å |
---|
データ登録者 | Rahighi, S. / Ikeda, F. / Kawasaki, M. / Akutsu, M. / Suzuki, N. / Kato, R. / Kensche, T. / Uejima, T. / Bloor, S. / Komander, D. ...Rahighi, S. / Ikeda, F. / Kawasaki, M. / Akutsu, M. / Suzuki, N. / Kato, R. / Kensche, T. / Uejima, T. / Bloor, S. / Komander, D. / Randow, F. / Wakatsuki, S. / Dikic, I. |
---|
引用 | ジャーナル: Cell(Cambridge,Mass.) / 年: 2009 タイトル: Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation 著者: Rahighi, S. / Ikeda, F. / Kawasaki, M. / Akutsu, M. / Suzuki, N. / Kato, R. / Kensche, T. / Uejima, T. / Bloor, S. / Komander, D. / Randow, F. / Wakatsuki, S. / Dikic, I. |
---|
履歴 | 登録 | 2008年11月11日 | 登録サイト: RCSB / 処理サイト: PDBJ |
---|
改定 1.0 | 2009年3月24日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2011年7月13日 | Group: Version format compliance |
---|
改定 1.2 | 2017年11月1日 | Group: Refinement description / カテゴリ: software |
---|
改定 1.3 | 2021年11月10日 | Group: Database references / カテゴリ: database_2 / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details |
---|
改定 1.4 | 2023年12月27日 | Group: Data collection / カテゴリ: chem_comp_atom / chem_comp_bond |
---|
|
---|