+Open data
-Basic information
Entry | Database: PDB / ID: 30000000 | ||||||
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Title | Crystal structure of spatzle cystine knot | ||||||
Components | Protein spaetzle | ||||||
Keywords | CYTOKINE / cystine knot / Toll ligand / Antimicrobial / Developmental protein / Fungicide / Glycoprotein / Secreted | ||||||
Function / homology | Function and homology information positive regulation of antimicrobial peptide biosynthetic process / positive regulation of antifungal peptide biosynthetic process / response to tumor cell / Formation of the trans-membrane 'signalling complex' / Adaptor protein complex binds to TL receptor at the plasma membrane / DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex' / DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex' / Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex' / Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex' / PLL kinase binds to TUB in the TL receptor 'signalling complex' ...positive regulation of antimicrobial peptide biosynthetic process / positive regulation of antifungal peptide biosynthetic process / response to tumor cell / Formation of the trans-membrane 'signalling complex' / Adaptor protein complex binds to TL receptor at the plasma membrane / DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex' / DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex' / Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex' / Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex' / PLL kinase binds to TUB in the TL receptor 'signalling complex' / positive regulation of antifungal peptide production / positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria / Toll binding / central nervous system formation / oocyte dorsal/ventral axis specification / cell competition in a multicellular organism / larval somatic muscle development / positive regulation of antimicrobial peptide production / antifungal innate immune response / dorsal/ventral axis specification / Toll signaling pathway / dorsal/ventral pattern formation / motor neuron axon guidance / defense response to fungus / cytokine activity / growth factor activity / response to hydrogen peroxide / response to wounding / defense response to Gram-negative bacterium / killing of cells of another organism / negative regulation of neuron apoptotic process / receptor ligand activity / defense response to Gram-positive bacterium / innate immune response / positive regulation of gene expression / protein homodimerization activity / extracellular space / extracellular region Similarity search - Function | ||||||
Biological species | Drosophila melanogaster (fruit fly) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution: 2.4 Å | ||||||
Authors | Hoffmann, A. / Funkner, A. / Neumann, P. / Juhnke, S. / Walther, M. / Schierhorn, A. / Weininger, U. / Balbach, J. / Reuter, G. / Stubbs, M.T. | ||||||
Citation | Journal: J.Biol.Chem. / Year: 2008 Title: Biophysical Characterization of Refolded Drosophila Spatzle, a Cystine Knot Protein, Reveals Distinct Properties of Three Isoforms Authors: Hoffmann, A. / Funkner, A. / Neumann, P. / Juhnke, S. / Walther, M. / Schierhorn, A. / Weininger, U. / Balbach, J. / Reuter, G. / Stubbs, M.T. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 3e07.cif.gz | 51.8 KB | Display | PDBx/mmCIF format |
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PDB format | pdb3e07.ent.gz | 35.4 KB | Display | PDB format |
PDBx/mmJSON format | 3e07.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 3e07_validation.pdf.gz | 455.2 KB | Display | wwPDB validaton report |
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Full document | 3e07_full_validation.pdf.gz | 460 KB | Display | |
Data in XML | 3e07_validation.xml.gz | 9.9 KB | Display | |
Data in CIF | 3e07_validation.cif.gz | 12.3 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/e0/3e07 ftp://data.pdbj.org/pub/pdb/validation_reports/e0/3e07 | HTTPS FTP |
-Related structure data
-Links
-Assembly
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Noncrystallographic symmetry (NCS) | NCS domain:
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