- PDB-3dd8: Carbonic anhydrase inhibitors. Interaction of the antitumor sulfa... -
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Basic information
Entry
Database: PDB / ID: 3dd8
Title
Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD-486019 with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies
Mass: 18.015 Da / Num. of mol.: 147 / Source method: isolated from a natural source / Formula: H2O
Nonpolymer details
THE LIGAND 2C7 IS NEW ANTITUMOR SULFAMATE AND CAN BE ALSO CALLED AS EMD486019.
Sequence details
THE NUMBER 126 IS SIMPLY SKIPPED IN THE NUMBERING. THE GAP IS IN THE SEQUENCE NUMBERING OF MODEL ...THE NUMBER 126 IS SIMPLY SKIPPED IN THE NUMBERING. THE GAP IS IN THE SEQUENCE NUMBERING OF MODEL 1CA2, THAT IS THE STARTING MODEL FOR ALL CA2 STRUCTURES.
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Experimental details
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Experiment
Experiment
Method: X-RAY DIFFRACTION / Number of used crystals: 1
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Sample preparation
Crystal
Density Matthews: 2.11 Å3/Da / Density % sol: 41.61 %
Crystal grow
Temperature: 277 K / Method: vapor diffusion, hanging drop / pH: 7.7 Details: 50mM Tris-HCl pH 7.7-7.8, 2mM sodium 4-(hydroxymercury)benzoate, VAPOR DIFFUSION, HANGING DROP, temperature 277K
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