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-Structure paper
Title | Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 18, Page 4282-4286, Year 2008 |
Publish date | Jun 5, 2008 (structure data deposition date) |
Authors | Temperini, C. / Innocenti, A. / Scozzafava, A. / Supuran, C.T. |
External links | Bioorg. Med. Chem. Lett. / PubMed:18640037 |
Methods | X-ray diffraction |
Resolution | 1.9 Å |
Structure data | PDB-3dd8: |
Chemicals | ChemComp-ZN: ChemComp-HG: ChemComp-2C7: ChemComp-HOH: |
Keywords | LYASE / carbonic anhydrase / inhibitors / antiglaucoma / OAO-ACID / Acetylation / Cytoplasm / Disease mutation / Metal-binding / Polymorphism / Zinc |