登録情報 | データベース: PDB / ID: 3cib |
---|
タイトル | Structure of BACE Bound to SCH727596 |
---|
要素 | Beta-secretase 1 |
---|
キーワード | HYDROLASE / BACE1 / Aspartyl protease |
---|
機能・相同性 | 機能・相同性情報
memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / amyloid-beta metabolic process / cellular response to manganese ion / prepulse inhibition ...memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / amyloid-beta metabolic process / cellular response to manganese ion / prepulse inhibition / detection of mechanical stimulus involved in sensory perception of pain / protein serine/threonine kinase binding / cellular response to copper ion / presynaptic modulation of chemical synaptic transmission / multivesicular body / hippocampal mossy fiber to CA3 synapse / response to lead ion / trans-Golgi network / recycling endosome / protein processing / cellular response to amyloid-beta / positive regulation of neuron apoptotic process / late endosome / synaptic vesicle / peptidase activity / amyloid-beta binding / endopeptidase activity / aspartic-type endopeptidase activity / amyloid fibril formation / endosome / endosome membrane / early endosome / lysosome / membrane raft / Amyloid fiber formation / endoplasmic reticulum lumen / axon / neuronal cell body / dendrite / enzyme binding / cell surface / Golgi apparatus / proteolysis / membrane / plasma membrane類似検索 - 分子機能 Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Eukaryotic aspartyl protease / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site ...Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Eukaryotic aspartyl protease / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Aspartic peptidase domain superfamily / Beta Barrel / Mainly Beta類似検索 - ドメイン・相同性 Chem-314 / D(-)-TARTARIC ACID / Beta-secretase 1類似検索 - 構成要素 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | X線回折 / シンクロトロン / 解像度: 1.72 Å |
---|
データ登録者 | Strickland, C. / Cumming, J. |
---|
引用 | ジャーナル: Bioorg.Med.Chem.Lett. / 年: 2008 タイトル: Rational design of novel, potent piperazinone and imidazolidinone BACE1 inhibitors 著者: Cumming, J.N. / Le, T.X. / Babu, S. / Carroll, C. / Chen, X. / Favreau, L. / Gaspari, P. / Guo, T. / Hobbs, D.W. / Huang, Y. / Iserloh, U. / Kennedy, M.E. / Kuvelkar, R. / Li, G. / Lowrie, J. ...著者: Cumming, J.N. / Le, T.X. / Babu, S. / Carroll, C. / Chen, X. / Favreau, L. / Gaspari, P. / Guo, T. / Hobbs, D.W. / Huang, Y. / Iserloh, U. / Kennedy, M.E. / Kuvelkar, R. / Li, G. / Lowrie, J. / McHugh, N.A. / Ozgur, L. / Pan, J. / Parker, E.M. / Saionz, K. / Stamford, A.W. / Strickland, C. / Tadesse, D. / Voigt, J. / Wang, L. / Wu, Y. / Zhang, L. / Zhang, Q. |
---|
履歴 | 登録 | 2008年3月11日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2008年6月10日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2011年7月13日 | Group: Version format compliance |
---|
改定 1.2 | 2017年10月25日 | Group: Refinement description / カテゴリ: software |
---|
|
---|