登録情報 | データベース: PDB / ID: 3ceh |
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タイトル | Human liver glycogen phosphorylase (tense state) in complex with the allosteric inhibitor AVE5688 |
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要素 | Glycogen phosphorylase, liver form |
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キーワード | TRANSFERASE / protein ligand complex / tense state / allosteric inhibitor / Allosteric enzyme / Carbohydrate metabolism / Disease mutation / Glycogen metabolism / Glycogen storage disease / Glycosyltransferase / Nucleotide-binding / Phosphoprotein / Pyridoxal phosphate |
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機能・相同性 | 機能・相同性情報
vitamin binding / purine nucleobase binding / 5-phosphoribose 1-diphosphate biosynthetic process / D-glucose binding / glycogen phosphorylase / glycogen phosphorylase activity / linear malto-oligosaccharide phosphorylase activity / SHG alpha-glucan phosphorylase activity / glycogen catabolic process / bile acid binding ...vitamin binding / purine nucleobase binding / 5-phosphoribose 1-diphosphate biosynthetic process / D-glucose binding / glycogen phosphorylase / glycogen phosphorylase activity / linear malto-oligosaccharide phosphorylase activity / SHG alpha-glucan phosphorylase activity / glycogen catabolic process / bile acid binding / Glycogen breakdown (glycogenolysis) / glycogen metabolic process / AMP binding / necroptotic process / response to bacterium / pyridoxal phosphate binding / glucose homeostasis / secretory granule lumen / ficolin-1-rich granule lumen / Neutrophil degranulation / extracellular exosome / extracellular region / ATP binding / identical protein binding / cytoplasm / cytosol類似検索 - 分子機能 Glycosyl transferase, family 35 / Glycogen/starch/alpha-glucan phosphorylase / Phosphorylase pyridoxal-phosphate attachment site / Carbohydrate phosphorylase / Phosphorylase pyridoxal-phosphate attachment site. / Glycogen Phosphorylase B; / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta類似検索 - ドメイン・相同性 Chem-AVE / N-acetyl-beta-D-glucopyranosylamine / PYRIDOXAL-5'-PHOSPHATE / PHOSPHATE ION / Glycogen phosphorylase, liver form類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 解像度: 2.8 Å |
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データ登録者 | Wendt, K.U. / Dreyer, M.K. / Anderka, O. / Klabunde, T. / Loenze, P. / Defossa, E. / Schmoll, D. |
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引用 | ジャーナル: Biochemistry / 年: 2008 タイトル: Thermodynamic characterization of allosteric glycogen phosphorylase inhibitors. 著者: Anderka, O. / Loenze, P. / Klabunde, T. / Dreyer, M.K. / Defossa, E. / Wendt, K.U. / Schmoll, D. |
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履歴 | 登録 | 2008年2月29日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2008年5月27日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Non-polymer description / Version format compliance |
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改定 1.2 | 2020年7月29日 | Group: Data collection / Derived calculations / Structure summary カテゴリ: chem_comp / entity ...chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / struct_conn / struct_site / struct_site_gen Item: _chem_comp.name / _entity.pdbx_description ..._chem_comp.name / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_conn.pdbx_leaving_atom_flag 解説: Carbohydrate remediation / Provider: repository / タイプ: Remediation |
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