登録情報 | データベース: PDB / ID: 3cbr |
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タイトル | Crystal structure of human Transthyretin (TTR) at pH3.5 |
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要素 | Transthyretin |
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キーワード | THYROXINE BINDING PROTEIN / TTR / AMYLOID / TRANSTHYRETIN / acidic pH / Disease mutation / Glycoprotein / Hormone / Polymorphism / Polyneuropathy / Retinol-binding / Secreted / Thyroid hormone / Vitamin A / TRANSPORT PROTEIN |
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機能・相同性 | 機能・相同性情報
Retinoid cycle disease events / thyroid hormone binding / The canonical retinoid cycle in rods (twilight vision) / purine nucleobase metabolic process / Non-integrin membrane-ECM interactions / Retinoid metabolism and transport / hormone activity / azurophil granule lumen / Amyloid fiber formation / Neutrophil degranulation ...Retinoid cycle disease events / thyroid hormone binding / The canonical retinoid cycle in rods (twilight vision) / purine nucleobase metabolic process / Non-integrin membrane-ECM interactions / Retinoid metabolism and transport / hormone activity / azurophil granule lumen / Amyloid fiber formation / Neutrophil degranulation / extracellular space / extracellular exosome / extracellular region / identical protein binding類似検索 - 分子機能 Transthyretin/hydroxyisourate hydrolase domain / Transthyretin, conserved site / Transthyretin signature 2. / Transthyretin, thyroxine binding site / Transthyretin signature 1. / Transthyretin / Transthyretin/hydroxyisourate hydrolase / Transthyretin/hydroxyisourate hydrolase domain / Transthyretin/hydroxyisourate hydrolase domain superfamily / HIUase/Transthyretin family ...Transthyretin/hydroxyisourate hydrolase domain / Transthyretin, conserved site / Transthyretin signature 2. / Transthyretin, thyroxine binding site / Transthyretin signature 1. / Transthyretin / Transthyretin/hydroxyisourate hydrolase / Transthyretin/hydroxyisourate hydrolase domain / Transthyretin/hydroxyisourate hydrolase domain superfamily / HIUase/Transthyretin family / Immunoglobulin-like / Sandwich / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.7 Å |
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データ登録者 | Mohamedmohaideen, N.N. / Palaninathan, S.K. / Snee, W.C. / Kelly, J.W. / C Sacchettini, J. |
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引用 | ジャーナル: J.Mol.Biol. / 年: 2008 タイトル: Structural insight into pH-induced conformational changes within the native human transthyretin tetramer. 著者: Palaninathan, S.K. / Mohamedmohaideen, N.N. / Snee, W.C. / Kelly, J.W. / Sacchettini, J.C. |
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履歴 | 登録 | 2008年2月22日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2008年8月12日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Version format compliance |
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改定 1.2 | 2023年8月30日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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