登録情報 | データベース: PDB / ID: 2zmd |
---|
タイトル | Crystal structure of human Mps1 catalytic domain T686A mutant in complex with SP600125 inhibitor |
---|
要素 | Dual specificity protein kinase TTK |
---|
キーワード | TRANSFERASE / kinase / Mps1 / SP600125 / T686A / ATP-binding / Nucleotide-binding / Phosphoprotein / Serine/threonine-protein kinase / Tyrosine-protein kinase |
---|
機能・相同性 | 機能・相同性情報
protein localization to meiotic spindle midzone / meiotic spindle assembly checkpoint signaling / kinetochore binding / female meiosis chromosome segregation / protein localization to kinetochore / dual-specificity kinase / spindle organization / mitotic spindle assembly checkpoint signaling / protein serine/threonine/tyrosine kinase activity / mitotic spindle organization ...protein localization to meiotic spindle midzone / meiotic spindle assembly checkpoint signaling / kinetochore binding / female meiosis chromosome segregation / protein localization to kinetochore / dual-specificity kinase / spindle organization / mitotic spindle assembly checkpoint signaling / protein serine/threonine/tyrosine kinase activity / mitotic spindle organization / chromosome segregation / kinetochore / spindle / protein tyrosine kinase activity / protein serine kinase activity / protein serine/threonine kinase activity / positive regulation of cell population proliferation / ATP binding / identical protein binding / membrane / nucleus / cytoplasm類似検索 - 分子機能 Protein kinase Mps1 family / Tetratricopeptide-like helical domain superfamily / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain ...Protein kinase Mps1 family / Tetratricopeptide-like helical domain superfamily / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 2,6-DIHYDROANTHRA/1,9-CD/PYRAZOL-6-ONE / Chem-7PE / Dual specificity protein kinase TTK類似検索 - 構成要素 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | X線回折 / 分子置換 / 解像度: 2.88 Å |
---|
データ登録者 | Chu, M.L.H. / Chavas, L.M.G. / Douglas, K.T. / Eyers, P.A. / Tabernero, L. |
---|
引用 | ジャーナル: J.Biol.Chem. / 年: 2008 タイトル: Crystal structure of the catalytic domain of the mitotic checkpoint kinase Mps1 in complex with SP600125. 著者: Chu, M.L. / Chavas, L.M. / Douglas, K.T. / Eyers, P.A. / Tabernero, L. |
---|
履歴 | 登録 | 2008年4月16日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
---|
改定 1.0 | 2008年5月13日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2011年7月13日 | Group: Advisory / Version format compliance |
---|
改定 1.2 | 2021年11月10日 | Group: Database references / Derived calculations / カテゴリ: database_2 / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
---|
改定 1.3 | 2023年11月1日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
---|
|
---|