Entry Database : PDB / ID : 2z81 Structure visualization Downloads & linksTitle Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide ComponentsToll-like receptor 2, Variable lymphocyte receptor B Details Keywords IMMUNE SYSTEM / TLR2 / Pam3CSK4 / lipopeptide / innate immunity / Cytoplasmic vesicle / Glycoprotein / Immune response / Inflammatory response / Leucine-rich repeat / Membrane / Receptor / TransmembraneFunction / homology Function and homology informationFunction Domain/homology Component
response to bacterial lipoprotein / diacyl lipopeptide binding / Beta defensins / triacyl lipopeptide binding / Toll-like receptor 2-Toll-like receptor 6 protein complex / detection of diacyl bacterial lipopeptide / positive regulation of neutrophil migration / cellular response to diacyl bacterial lipopeptide / Toll-like receptor 1-Toll-like receptor 2 protein complex / detection of triacyl bacterial lipopeptide ... response to bacterial lipoprotein / diacyl lipopeptide binding / Beta defensins / triacyl lipopeptide binding / Toll-like receptor 2-Toll-like receptor 6 protein complex / detection of diacyl bacterial lipopeptide / positive regulation of neutrophil migration / cellular response to diacyl bacterial lipopeptide / Toll-like receptor 1-Toll-like receptor 2 protein complex / detection of triacyl bacterial lipopeptide / cellular response to triacyl bacterial lipopeptide / cellular response to bacterial lipopeptide / Regulation of TLR by endogenous ligand / lipoteichoic acid binding / negative regulation of synapse assembly / response to molecule of fungal origin / cell surface pattern recognition receptor signaling pathway / regulation of dendritic cell cytokine production / response to peptidoglycan / positive regulation of xenophagy / positive regulation of interleukin-18 production / central nervous system myelin formation / xenophagy / leukotriene metabolic process / neutrophil migration / negative regulation of actin filament polymerization / response to fatty acid / lipopeptide binding / cellular response to peptidoglycan / negative regulation of interleukin-12 production / NAD+ nucleotidase, cyclic ADP-ribose generating / negative regulation of interleukin-17 production / microglia development / negative regulation of phagocytosis / positive regulation of macrophage cytokine production / positive regulation of leukocyte migration / positive regulation of intracellular signal transduction / MyD88-dependent toll-like receptor signaling pathway / pattern recognition receptor activity / toll-like receptor signaling pathway / positive regulation of oligodendrocyte differentiation / nitric oxide metabolic process / leukocyte migration / positive regulation of nitric-oxide synthase biosynthetic process / cellular response to lipoteichoic acid / positive regulation of interleukin-10 production / positive regulation of chemokine production / nitric oxide biosynthetic process / ERK1 and ERK2 cascade / positive regulation of interleukin-12 production / positive regulation of interferon-beta production / Neutrophil degranulation / learning / positive regulation of interleukin-1 beta production / positive regulation of cytokine production / cell projection / response to bacterium / microglial cell activation / defense response / positive regulation of inflammatory response / phagocytic vesicle membrane / transmembrane signaling receptor activity / positive regulation of interleukin-6 production / positive regulation of tumor necrosis factor production / positive regulation of nitric oxide biosynthetic process / signaling receptor activity / amyloid-beta binding / cell body / positive regulation of ERK1 and ERK2 cascade / defense response to Gram-positive bacterium / inflammatory response / membrane raft / negative regulation of cell population proliferation / external side of plasma membrane / innate immune response / protein-containing complex binding / Golgi apparatus / cell surface / positive regulation of transcription by RNA polymerase II / membrane / plasma membrane Similarity search - Function Variable lymphocyte receptor, C-terminal / Domain of unknown function (DUF3439) / Toll-like receptor / Leucine rich repeat N-terminal domain / Leucine-rich repeat N-terminal domain / Leucine rich repeat N-terminal domain / Leucine Rich repeat / TIR domain / Leucine-rich repeats, bacterial type / Cysteine-rich flanking region, C-terminal ... Variable lymphocyte receptor, C-terminal / Domain of unknown function (DUF3439) / Toll-like receptor / Leucine rich repeat N-terminal domain / Leucine-rich repeat N-terminal domain / Leucine rich repeat N-terminal domain / Leucine Rich repeat / TIR domain / Leucine-rich repeats, bacterial type / Cysteine-rich flanking region, C-terminal / Leucine rich repeat C-terminal domain / Toll - interleukin 1 - resistance / Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) / Ribonuclease Inhibitor / TIR domain profile. / Toll/interleukin-1 receptor homology (TIR) domain / Toll/interleukin-1 receptor homology (TIR) domain superfamily / Alpha-Beta Horseshoe / Leucine rich repeat / Leucine-rich repeat, typical subtype / Leucine-rich repeats, typical (most populated) subfamily / Leucine-rich repeat profile. / Leucine-rich repeat / Leucine-rich repeat domain superfamily / Alpha Beta Similarity search - Domain/homologyBiological species Mus musculus (house mouse)Eptatretus burgeri (inshore hagfish)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.8 Å DetailsAuthors Lee, J.O. / Jin, M.S. / Kim, S.E. / Heo, J.Y. CitationJournal : Cell(Cambridge,Mass.) / Year : 2007Title : Crystal Structure of the TLR1-TLR2 Heterodimer Induced by Binding of a Tri-Acylated LipopeptideAuthors : Jin, M.S. / Kim, S.E. / Heo, J.Y. / Lee, M.E. / Kim, H.M. / Paik, S.G. / Lee, H. / Lee, J.O. History Deposition Aug 30, 2007 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Oct 2, 2007 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2011 Group : Non-polymer description / Version format complianceRevision 1.2 Aug 16, 2017 Group : Refinement description / Source and taxonomy / Category : entity_src_gen / softwareRevision 2.0 Jul 29, 2020 Group : Advisory / Atomic model ... Advisory / Atomic model / Data collection / Database references / Derived calculations / Structure summary Category : atom_site / chem_comp ... atom_site / chem_comp / database_PDB_caveat / entity / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / pdbx_unobs_or_zero_occ_atoms / struct_asym / struct_conn / struct_ref_seq_dif / struct_site / struct_site_gen Item : _atom_site.auth_asym_id / _atom_site.auth_seq_id ... _atom_site.auth_asym_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_entity_id / _chem_comp.name / _chem_comp.type / _entity.formula_weight / _entity.pdbx_description / _entity.pdbx_number_of_molecules / _entity.type / _pdbx_struct_assembly_gen.asym_id_list / _pdbx_unobs_or_zero_occ_atoms.label_asym_id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_comp_id / _struct_ref_seq_dif.details Description : Carbohydrate remediation / Provider : repository / Type : RemediationRevision 2.1 Nov 1, 2023 Group : Data collection / Database references ... Data collection / Database references / Refinement description / Structure summary Category : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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