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- PDB-2xrb: Structure of the N-terminal four domains of the complement regula... -
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Open data
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Basic information
Entry | Database: PDB / ID: 2xrb | ||||||
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Title | Structure of the N-terminal four domains of the complement regulator Rat Crry | ||||||
![]() | COMPLEMENT REGULATORY PROTEIN CRRY | ||||||
![]() | IMMUNE SYSTEM / IMMUNOLOGY | ||||||
Function / homology | ![]() Regulation of Complement cascade / negative regulation of complement activation / negative regulation of complement activation, classical pathway / regulation of complement-dependent cytotoxicity / regulation of complement activation / T cell mediated immunity / complement activation / Neutrophil degranulation / complement activation, classical pathway / female pregnancy ...Regulation of Complement cascade / negative regulation of complement activation / negative regulation of complement activation, classical pathway / regulation of complement-dependent cytotoxicity / regulation of complement activation / T cell mediated immunity / complement activation / Neutrophil degranulation / complement activation, classical pathway / female pregnancy / cellular response to hypoxia / basolateral plasma membrane / in utero embryonic development / receptor complex / external side of plasma membrane / innate immune response / cell surface / extracellular space / plasma membrane Similarity search - Function | ||||||
Biological species | ![]() ![]() | ||||||
Method | ![]() ![]() ![]() | ||||||
![]() | Leath, K.J. / Roversi, P. / Johnson, S. / Morgan, B.P. / Lea, S.M. | ||||||
![]() | ![]() Title: Structures of the Rat Complement Regulator Crry. Authors: Roversi, P. / Johnson, S. / Caesar, J.J.E. / Mclean, F. / Leath, K.J. / Tsiftsoglou, S.A. / Morgan, B.P. / Harris, C.L. / Sim, R.B. / Lea, S.M. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 70.9 KB | Display | ![]() |
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PDB format | ![]() | 51.8 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 451.2 KB | Display | ![]() |
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Full document | ![]() | 451.7 KB | Display | |
Data in XML | ![]() | 12.9 KB | Display | |
Data in CIF | ![]() | 17.8 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 2xrdC ![]() 1gknS ![]() 1ok9S C: citing same article ( S: Starting model for refinement |
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Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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Unit cell |
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Components
#1: Protein | Mass: 31925.393 Da / Num. of mol.: 1 Fragment: EXTRACELLULAR N-TERMINAL FOUR CCP DOMAINS, RESIDUES 1-288 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() ![]() | ||||
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#2: Chemical | #3: Chemical | ChemComp-EDO / #4: Water | ChemComp-HOH / | |
-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 3.1 Å3/Da / Density % sol: 60.5 % / Description: NONE |
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Crystal grow | pH: 4.6 Details: 0.2 M AMMONIUM SULPHATE, 0.1 M SODIUM ACETATE PH 4.6, 30% W/V PEGMME 2000. |
-Data collection
Diffraction | Mean temperature: 120 K |
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Diffraction source | Source: ![]() ![]() ![]() |
Detector | Type: ADSC CCD / Detector: CCD / Date: Jul 11, 2010 |
Radiation | Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength: 0.9763 Å / Relative weight: 1 |
Reflection | Resolution: 2.5→30 Å / Num. obs: 13105 / % possible obs: 99.8 % / Observed criterion σ(I): 0 / Redundancy: 6.6 % / Biso Wilson estimate: 45.42 Å2 / Rmerge(I) obs: 0.12 / Net I/σ(I): 12.8 |
Reflection shell | Resolution: 2.41→2.47 Å / Redundancy: 5 % / Rmerge(I) obs: 0.64 / Mean I/σ(I) obs: 2.5 / % possible all: 97.9 |
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Processing
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Refinement | Method to determine structure: ![]() Starting model: DOMAINS FROM PDB ENTRIES 1OK9 AND 1GKN Resolution: 2.5→29.26 Å / Cor.coef. Fo:Fc: 0.9221 / Cor.coef. Fo:Fc free: 0.8712 / SU R Cruickshank DPI: 0.322 / Cross valid method: THROUGHOUT / σ(F): 0 / SU R Blow DPI: 0.389 / SU Rfree Blow DPI: 0.251 / SU Rfree Cruickshank DPI: 0.24
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Displacement parameters | Biso mean: 32.65 Å2
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Refine analyze | Luzzati coordinate error obs: 0.274 Å | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refinement step | Cycle: LAST / Resolution: 2.5→29.26 Å
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Refine LS restraints |
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LS refinement shell | Resolution: 2.5→2.7 Å / Total num. of bins used: 7
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