Entry Database : PDB / ID : 2xpc Structure visualization Downloads & linksTitle Second-generation sulfonamide inhibitors of MurD: Activity optimisation with conformationally rigid analogues of D-glutamic acid ComponentsUDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE Details Keywords LIGASE / CELL CYCLE / CELL DIVISION / CELL SHAPE / CELL WALL BIOGENESIS/DEGRADATION / LIGASE SYNTHESISFunction / homology Function and homology informationFunction Domain/homology Component
UDP-N-acetylmuramoyl-L-alanine-D-glutamate ligase / UDP-N-acetylmuramoylalanine-D-glutamate ligase activity / peptidoglycan biosynthetic process / cell wall organization / regulation of cell shape / cell cycle / cell division / ATP binding / identical protein binding / cytoplasm Similarity search - Function Mur ligase MurD-like, N-terminal domain / UDP-N-acetylmuramoylalanine-D-glutamate ligase MurD / Mur ligase, C-terminal domain / Mur-like, catalytic domain / Mur ligase, C-terminal / Mur ligase, glutamate ligase domain / Mur ligase, C-terminal domain superfamily / Mur ligase, central / Mur-like, catalytic domain superfamily / Mur ligase middle domain ... Mur ligase MurD-like, N-terminal domain / UDP-N-acetylmuramoylalanine-D-glutamate ligase MurD / Mur ligase, C-terminal domain / Mur-like, catalytic domain / Mur ligase, C-terminal / Mur ligase, glutamate ligase domain / Mur ligase, C-terminal domain superfamily / Mur ligase, central / Mur-like, catalytic domain superfamily / Mur ligase middle domain / UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase / Protein-Tyrosine Phosphatase; Chain A / NAD(P)-binding Rossmann-like Domain / Alpha-Beta Complex / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species ESCHERICHIA COLI (E. coli)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.49 Å DetailsAuthors Sosic, I. / Barreteau, H. / Simcic, M. / Sink, R. / Cesar, J. / Golic-Grdadolnik, S. / Contreras-Martel, C. / Dessen, A. / Amoroso, A. / Joris, B. ...Sosic, I. / Barreteau, H. / Simcic, M. / Sink, R. / Cesar, J. / Golic-Grdadolnik, S. / Contreras-Martel, C. / Dessen, A. / Amoroso, A. / Joris, B. / Blanot, D. / Gobec, S. CitationJournal : Eur.J.Med.Chem / Year : 2011Title : Second-Generation Sulfonamide Inhibitors of D- Glutamic Acid-Adding Enzyme: Activity Optimisation with Conformationally Rigid Analogues of D- Glutamic Acid.Authors : Sosi, I. / Barreteau, H. / Sim, M. / Sink, R. / Cesar, J. / Zega, A. / Grdadolnik, S.G. / Contreras-Martel, C. / Dessen, A. / Amoroso, A. / Joris, B. / Blanot, D. / Gobec, S. History Deposition Aug 26, 2010 Deposition site : PDBE / Processing site : PDBERevision 1.0 May 18, 2011 Provider : repository / Type : Initial releaseRevision 1.1 Aug 10, 2011 Group : Database references / Version format complianceRevision 1.2 Feb 7, 2018 Group : Source and taxonomy / Category : entity_src_genItem : _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id / _entity_src_gen.pdbx_host_org_scientific_name / _entity_src_gen.pdbx_host_org_strainRevision 1.3 Dec 20, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / struct_conn / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_conn.pdbx_leaving_atom_flag / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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