Entry Database : PDB / ID : 2xdg Structure visualization Downloads & linksTitle Crystal structure of the extracellular domain of human growth hormone releasing hormone receptor. ComponentsGROWTH HORMONE-RELEASING HORMONE RECEPTOR Details Keywords SIGNALING PROTEIN / RECEPTOR / MEMBRANE PROTEINFunction / homology Function and homology informationFunction Domain/homology Component
regulation of intracellular steroid hormone receptor signaling pathway / somatotropin secreting cell development / growth hormone-releasing hormone receptor activity / growth hormone secretion / positive regulation of growth hormone secretion / regulation of protein metabolic process / positive regulation of multicellular organism growth / multicellular organismal reproductive process / G protein-coupled peptide receptor activity / hormone metabolic process ... regulation of intracellular steroid hormone receptor signaling pathway / somatotropin secreting cell development / growth hormone-releasing hormone receptor activity / growth hormone secretion / positive regulation of growth hormone secretion / regulation of protein metabolic process / positive regulation of multicellular organism growth / multicellular organismal reproductive process / G protein-coupled peptide receptor activity / hormone metabolic process / nuclear outer membrane / positive regulation of insulin-like growth factor receptor signaling pathway / nuclear inner membrane / growth factor binding / peptide hormone binding / response to glucocorticoid / cell maturation / lactation / secretory granule / establishment of localization in cell / G protein-coupled receptor activity / determination of adult lifespan / response to insulin / adenylate cyclase-activating G protein-coupled receptor signaling pathway / nuclear matrix / Glucagon-type ligand receptors / response to estrogen / cellular response to insulin stimulus / G alpha (s) signalling events / cell surface receptor signaling pathway / positive regulation of cell population proliferation / cell surface / membrane / plasma membrane / cytoplasm Similarity search - Function GPCR, family 2, growth hormone-releasing hormone receptor / GPCR, family 2, extracellular hormone receptor domain / Hormone receptor fold / G-protein coupled receptors family 2 signature 1. / Hormone receptor domain / GPCR, family 2, extracellular hormone receptor domain / G-protein coupled receptors family 2 profile 1. / Domain present in hormone receptors / GPCR family 2, extracellular hormone receptor domain superfamily / G-protein coupled receptors family 2 signature 2. ... GPCR, family 2, growth hormone-releasing hormone receptor / GPCR, family 2, extracellular hormone receptor domain / Hormone receptor fold / G-protein coupled receptors family 2 signature 1. / Hormone receptor domain / GPCR, family 2, extracellular hormone receptor domain / G-protein coupled receptors family 2 profile 1. / Domain present in hormone receptors / GPCR family 2, extracellular hormone receptor domain superfamily / G-protein coupled receptors family 2 signature 2. / GPCR, family 2, secretin-like, conserved site / GPCR, family 2, secretin-like / 7 transmembrane receptor (Secretin family) / GPCR, family 2-like / G-protein coupled receptors family 2 profile 2. / Few Secondary Structures / Irregular Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.95 Å DetailsAuthors Pike, A.C.W. / Quigley, A. / Barr, A.J. / Burgess Brown, N. / Shrestha, L. / Yang, J. / Chaikuad, A. / Vollmar, M. / Muniz, J.R.C. / von Delft, F. ...Pike, A.C.W. / Quigley, A. / Barr, A.J. / Burgess Brown, N. / Shrestha, L. / Yang, J. / Chaikuad, A. / Vollmar, M. / Muniz, J.R.C. / von Delft, F. / Edwards, A. / Arrowsmith, C.H. / Weigelt, J. / Bountra, C. / Carpenter, E.P. CitationJournal : To be Published Title : Crystal Structure of the Extracellular Domain of Human Growth Hormone Releasing Hormone Receptor.Authors: Pike, A.C.W. / Quigley, A. / Barr, A.J. / Burgess Brown, N. / Shrestha, L. / Yang, J. / Chaikuad, A. / Vollmar, M. / Muniz, J.R.C. / von Delft, F. / Edwards, A. / Arrowsmith, C.H. / Weigelt, ... Authors : Pike, A.C.W. / Quigley, A. / Barr, A.J. / Burgess Brown, N. / Shrestha, L. / Yang, J. / Chaikuad, A. / Vollmar, M. / Muniz, J.R.C. / von Delft, F. / Edwards, A. / Arrowsmith, C.H. / Weigelt, J. / Bountra, C. / Carpenter, E.P. History Deposition Apr 30, 2010 Deposition site : PDBE / Processing site : PDBERevision 1.0 Jun 16, 2010 Provider : repository / Type : Initial releaseRevision 1.1 May 8, 2011 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format complianceRevision 1.3 Jan 24, 2018 Group : Database references / Structure summary / Category : audit_author / citation_author / Item : _audit_author.name / _citation_author.nameRevision 1.4 Dec 20, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _pdbx_struct_conn_angle.ptnr1_auth_asym_id / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr1_symmetry / _pdbx_struct_conn_angle.ptnr3_auth_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.ptnr3_symmetry / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr1_symmetry / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_conn.ptnr2_symmetry / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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