Entry | Database: PDB / ID: 2wfh |
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Title | The Human Slit 2 Dimerization Domain D4 |
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Components | SLIT HOMOLOG 2 PROTEIN C-PRODUCT |
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Keywords | SPLICING / DEVELOPMENTAL PROTEIN / NEUROGENESIS / GLYCOPROTEIN / LEUCINE-RICH REPEAT / DISULFIDE BOND / DIFFERENTIATION / EGF-LIKE DOMAIN / ID14-EH4 / ROUNDABOUT / CHEMOTAXIS / NERVE CELL / MIDLINE / HEPARAN / HEPARIN / SECRETED / GUIDANCE / D4 / XDS / LRR / SLIT / AXON / NEURON / PHASER / SULFATE |
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Function / homology | Function and homology information
negative regulation of leukocyte chemotaxis / corticospinal neuron axon guidance through spinal cord / negative regulation of lamellipodium assembly / induction of negative chemotaxis / negative regulation of mononuclear cell migration / negative regulation of retinal ganglion cell axon guidance / apoptotic process involved in luteolysis / negative regulation of monocyte chemotaxis / chemorepulsion involved in postnatal olfactory bulb interneuron migration / Roundabout binding ...negative regulation of leukocyte chemotaxis / corticospinal neuron axon guidance through spinal cord / negative regulation of lamellipodium assembly / induction of negative chemotaxis / negative regulation of mononuclear cell migration / negative regulation of retinal ganglion cell axon guidance / apoptotic process involved in luteolysis / negative regulation of monocyte chemotaxis / chemorepulsion involved in postnatal olfactory bulb interneuron migration / Roundabout binding / negative regulation of smooth muscle cell chemotaxis / negative regulation of cellular response to growth factor stimulus / cellular response to heparin / negative regulation of small GTPase mediated signal transduction / negative regulation of chemokine-mediated signaling pathway / response to cortisol / laminin-1 binding / negative regulation of smooth muscle cell migration / axon extension involved in axon guidance / Formation of the ureteric bud / Netrin-1 signaling / GTPase inhibitor activity / Role of ABL in ROBO-SLIT signaling / Regulation of commissural axon pathfinding by SLIT and ROBO / negative regulation of neutrophil chemotaxis / SLIT2:ROBO1 increases RHOA activity / Roundabout signaling pathway / Inactivation of CDC42 and RAC1 / negative regulation of actin filament polymerization / Signaling by ROBO receptors / pulmonary valve morphogenesis / negative regulation of vascular permeability / aortic valve morphogenesis / cell migration involved in sprouting angiogenesis / Activation of RAC1 / motor neuron axon guidance / proteoglycan binding / negative regulation of endothelial cell migration / ureteric bud development / negative chemotaxis / retinal ganglion cell axon guidance / positive regulation of axonogenesis / branching morphogenesis of an epithelial tube / ventricular septum morphogenesis / cellular response to hormone stimulus / negative regulation of cell migration / negative regulation of protein phosphorylation / axon guidance / negative regulation of cell growth / Regulation of expression of SLITs and ROBOs / heparin binding / positive regulation of apoptotic process / calcium ion binding / protein homodimerization activity / extracellular space / extracellular exosome / extracellular region / identical protein binding / membrane / cytoplasmSimilarity search - Function Leucine rich repeat C-terminal domain / Follistatin-like, N-terminal / Follistatin-N-terminal domain-like / Laminin G domain / EGF-like, conserved site / Human growth factor-like EGF / C-terminal cystine knot signature. / C-terminal cystine knot domain profile. / Leucine rich repeat N-terminal domain / Cystine knot, C-terminal ...Leucine rich repeat C-terminal domain / Follistatin-like, N-terminal / Follistatin-N-terminal domain-like / Laminin G domain / EGF-like, conserved site / Human growth factor-like EGF / C-terminal cystine knot signature. / C-terminal cystine knot domain profile. / Leucine rich repeat N-terminal domain / Cystine knot, C-terminal / C-terminal cystine knot-like domain (CTCK) / Laminin G domain profile. / Leucine-rich repeat N-terminal domain / Leucine rich repeat N-terminal domain / Laminin G domain / Laminin G domain / Leucine Rich Repeat / Cysteine-rich flanking region, C-terminal / Leucine rich repeat C-terminal domain / Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) / Ribonuclease Inhibitor / Leucine-rich repeat, SDS22-like subfamily / Alpha-Beta Horseshoe / EGF-like domain / EGF-type aspartate/asparagine hydroxylation site / EGF-like calcium-binding, conserved site / Calcium-binding EGF-like domain signature. / Aspartic acid and asparagine hydroxylation site. / EGF-like calcium-binding domain / Calcium-binding EGF-like domain / Leucine rich repeat / Leucine-rich repeat, typical subtype / Leucine-rich repeats, typical (most populated) subfamily / Epidermal growth factor-like domain. / Leucine-rich repeat profile. / EGF-like domain profile. / EGF-like domain signature 2. / Leucine-rich repeat / EGF-like domain signature 1. / EGF-like domain / Leucine-rich repeat domain superfamily / Concanavalin A-like lectin/glucanase domain superfamily / Alpha BetaSimilarity search - Domain/homology |
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Biological species | HOMO SAPIENS (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.8 Å |
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Authors | Seiradake, E. / von Philipsborn, A.C. / Henry, M. / Fritz, M. / Lortat-Jacob, H. / Jamin, M. / Hemrika, W. / Bastmeyer, M. / Cusack, S. / McCarthy, A.A. |
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Citation | Journal: EMBO Rep. / Year: 2009 Title: Structure and functional relevance of the Slit2 homodimerization domain. Authors: Seiradake, E. / von Philipsborn, A.C. / Henry, M. / Fritz, M. / Lortat-Jacob, H. / Jamin, M. / Hemrika, W. / Bastmeyer, M. / Cusack, S. / McCarthy, A.A. |
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History | Deposition | Apr 6, 2009 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Apr 21, 2009 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jul 13, 2011 | Group: Advisory / Version format compliance |
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Revision 1.2 | Sep 28, 2011 | Group: Database references |
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Revision 1.3 | Jan 10, 2018 | Group: Database references / Category: citation / citation_author Item: _citation.journal_abbrev / _citation.journal_id_ISSN ..._citation.journal_abbrev / _citation.journal_id_ISSN / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.title / _citation_author.name |
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Revision 1.4 | Dec 13, 2023 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Other / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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