Entry Database : PDB / ID : 2v9t Structure visualization Downloads & linksTitle Complex between the second LRR domain of Slit2 and The first Ig domain from Robo1 ComponentsROUNDABOUT HOMOLOG 1 SLIT HOMOLOG 2 PROTEIN N-PRODUCT DetailsKeywords STRUCTURAL PROTEIN/RECEPTOR / STRUCTURAL PROTEIN-RECEPTOR COMPLEX / DEVELOPMENTAL PROTEIN / IG DOMAIN / ROUNDABOUT / CHEMOTAXIS / LRR DOMAIN / IMMUNOGLOBULIN DOMAIN / LEUCINE-RICH REPEAT / NEURONAL DEVELOPMENT / PHOSPHORYLATION / EGF-LIKE DOMAIN / DISEASE MUTATION / SLIT2 / LIGAND / MEMBRANE / SECRETED / RECEPTOR / NEUROGENESIS / GLYCOPROTEIN / TRANSMEMBRANE / PROTO-ONCOGENE / DIFFERENTIATION STRUCTURAL PROTEIN/RECEPTOR / COMPLEXFunction / homology Function and homology informationFunction Domain/homology Component
negative regulation of leukocyte chemotaxis / corticospinal neuron axon guidance through spinal cord / negative regulation of lamellipodium assembly / induction of negative chemotaxis / negative regulation of mononuclear cell migration / negative regulation of retinal ganglion cell axon guidance / apoptotic process involved in luteolysis / negative regulation of monocyte chemotaxis / chemorepulsion involved in postnatal olfactory bulb interneuron migration / Roundabout binding ... negative regulation of leukocyte chemotaxis / corticospinal neuron axon guidance through spinal cord / negative regulation of lamellipodium assembly / induction of negative chemotaxis / negative regulation of mononuclear cell migration / negative regulation of retinal ganglion cell axon guidance / apoptotic process involved in luteolysis / negative regulation of monocyte chemotaxis / chemorepulsion involved in postnatal olfactory bulb interneuron migration / Roundabout binding / negative regulation of negative chemotaxis / negative regulation of smooth muscle cell chemotaxis / negative regulation of cellular response to growth factor stimulus / cellular response to heparin / Regulation of cortical dendrite branching / negative regulation of small GTPase mediated signal transduction / negative regulation of mammary gland epithelial cell proliferation / LRR domain binding / negative regulation of chemokine-mediated signaling pathway / response to cortisol / laminin-1 binding / negative regulation of smooth muscle cell migration / heart induction / axon extension involved in axon guidance / Formation of the ureteric bud / axon guidance receptor activity / Netrin-1 signaling / positive regulation of vascular endothelial growth factor signaling pathway / GTPase inhibitor activity / Role of ABL in ROBO-SLIT signaling / Regulation of commissural axon pathfinding by SLIT and ROBO / negative regulation of neutrophil chemotaxis / SLIT2:ROBO1 increases RHOA activity / Roundabout signaling pathway / Inactivation of CDC42 and RAC1 / endocardial cushion formation / negative regulation of actin filament polymerization / Signaling by ROBO receptors / pulmonary valve morphogenesis / outflow tract septum morphogenesis / negative regulation of vascular permeability / aortic valve morphogenesis / positive regulation of vascular endothelial growth factor receptor signaling pathway / cell migration involved in sprouting angiogenesis / axon midline choice point recognition / Activation of RAC1 / motor neuron axon guidance / aorta development / proteoglycan binding / negative regulation of endothelial cell migration / ureteric bud development / negative chemotaxis / positive regulation of axonogenesis / retinal ganglion cell axon guidance / positive regulation of Rho protein signal transduction / branching morphogenesis of an epithelial tube / ventricular septum morphogenesis / positive regulation of Notch signaling pathway / homophilic cell adhesion via plasma membrane adhesion molecules / cellular response to hormone stimulus / endoplasmic reticulum-Golgi intermediate compartment membrane / negative regulation of cell migration / negative regulation of protein phosphorylation / synapse organization / axon guidance / positive regulation of MAP kinase activity / negative regulation of cell growth / Regulation of expression of SLITs and ROBOs / activation of cysteine-type endopeptidase activity involved in apoptotic process / nervous system development / heparin binding / cell adhesion / neuron projection / positive regulation of apoptotic process / axon / negative regulation of gene expression / neuronal cell body / calcium ion binding / positive regulation of gene expression / cell surface / protein homodimerization activity / extracellular space / extracellular exosome / extracellular region / identical protein binding / membrane / plasma membrane / cytoplasm Similarity search - Function Roundabout homologue 1 / Leucine rich repeat C-terminal domain / Follistatin-like, N-terminal / Follistatin-N-terminal domain-like / Laminin G domain / EGF-like, conserved site / Human growth factor-like EGF / C-terminal cystine knot signature. / C-terminal cystine knot domain profile. / Leucine rich repeat N-terminal domain ... Roundabout homologue 1 / Leucine rich repeat C-terminal domain / Follistatin-like, N-terminal / Follistatin-N-terminal domain-like / Laminin G domain / EGF-like, conserved site / Human growth factor-like EGF / C-terminal cystine knot signature. / C-terminal cystine knot domain profile. / Leucine rich repeat N-terminal domain / Cystine knot, C-terminal / C-terminal cystine knot-like domain (CTCK) / Laminin G domain profile. / Leucine-rich repeat N-terminal domain / Leucine rich repeat N-terminal domain / Laminin G domain / Laminin G domain / Leucine Rich Repeat / Cysteine-rich flanking region, C-terminal / Leucine rich repeat C-terminal domain / Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) / Ribonuclease Inhibitor / Leucine-rich repeat, SDS22-like subfamily / Alpha-Beta Horseshoe / EGF-like domain / EGF-type aspartate/asparagine hydroxylation site / Immunoglobulin domain / EGF-like calcium-binding, conserved site / Calcium-binding EGF-like domain signature. / Aspartic acid and asparagine hydroxylation site. / EGF-like calcium-binding domain / Calcium-binding EGF-like domain / Leucine rich repeat / Leucine-rich repeat, typical subtype / Leucine-rich repeats, typical (most populated) subfamily / Immunoglobulin I-set / Immunoglobulin I-set domain / Epidermal growth factor-like domain. / Leucine-rich repeat profile. / EGF-like domain profile. / EGF-like domain signature 2. / Leucine-rich repeat / Fibronectin type III domain / EGF-like domain signature 1. / EGF-like domain / Fibronectin type 3 domain / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Immunoglobulin V-Type / Fibronectin type-III domain profile. / Leucine-rich repeat domain superfamily / Fibronectin type III / Fibronectin type III superfamily / Immunoglobulin V-set domain / Concanavalin A-like lectin/glucanase domain superfamily / Immunoglobulin subtype / Immunoglobulin / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulins / Immunoglobulin-like fold / Immunoglobulin-like / Sandwich / Mainly Beta / Alpha Beta Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.7 Å DetailsAuthors Morlot, C. / Cusack, S. / McCarthy, A.A. Citation Show more 1 items Show lessHistory Deposition Aug 25, 2007 Deposition site : PDBE / Processing site : PDBERevision 1.0 Sep 25, 2007 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2011 Group : Advisory / Version format complianceRevision 1.2 Aug 29, 2012 Group : Database references
Show all Show less Remark 700 SHEET THE SHEET STRUCTURE OF THIS MOLECULE IS BIFURCATED. IN ORDER TO REPRESENT THIS FEATURE IN ... SHEET THE SHEET STRUCTURE OF THIS MOLECULE IS BIFURCATED. IN ORDER TO REPRESENT THIS FEATURE IN THE SHEET RECORDS BELOW, TWO SHEETS ARE DEFINED.