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Yorodumi- PDB-2vze: Crystal structure of human acyl-CoA synthetase medium-chain famil... -
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-Basic information
Entry | Database: PDB / ID: 2vze | ||||||
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Title | Crystal structure of human acyl-CoA synthetase medium-chain family member 2A (L64P mutation) in complex with AMP | ||||||
Components | ACYL-COENZYME A SYNTHETASE ACSM2A, MITOCHONDRIAL | ||||||
Keywords | LIGASE / METAL-BINDING / TRANSIT PEPTIDE / LIPID METABOLISM / NUCLEOTIDE-BINDING / ATP-BINDING / ADENYLATE-FORMING ENZYME / FATTY ACID METABOLISM / FATTY ACID-COA LIGASE | ||||||
Function / homology | Function and homology information Conjugation of salicylate with glycine / fatty acid ligase activity / decanoate-CoA ligase activity / medium-chain acyl-CoA ligase / : / benzoate-CoA ligase / benzoate-CoA ligase activity / medium-chain fatty-acyl-CoA metabolic process / fatty-acyl-CoA synthase activity / acyl-CoA metabolic process ...Conjugation of salicylate with glycine / fatty acid ligase activity / decanoate-CoA ligase activity / medium-chain acyl-CoA ligase / : / benzoate-CoA ligase / benzoate-CoA ligase activity / medium-chain fatty-acyl-CoA metabolic process / fatty-acyl-CoA synthase activity / acyl-CoA metabolic process / triglyceride homeostasis / Aspirin ADME / fatty acid biosynthetic process / glucose homeostasis / mitochondrial matrix / mitochondrion / ATP binding / metal ion binding Similarity search - Function | ||||||
Biological species | HOMO SAPIENS (human) | ||||||
Method | X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution: 2.45 Å | ||||||
Authors | Yue, W.W. / Kochan, G.T. / Pilka, E.S. / Bhatia, C. / von Delft, F. / Arrowsmith, C.H. / Edwards, A.M. / Wikstrom, M. / Bountra, C. / Oppermann, U. | ||||||
Citation | Journal: J.Mol.Biol. / Year: 2009 Title: Structural Snapshots for the Conformation- Dependent Catalysis by Human Medium-Chain Acyl- Coenzyme a Synthetase Acsm2A. Authors: Kochan, G. / Pilka, E.S. / Delft, F.V. / Oppermann, U. / Yue, W.W. | ||||||
History |
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Remark 700 | SHEET THE SHEET STRUCTURE OF THIS MOLECULE IS BIFURCATED. IN ORDER TO REPRESENT THIS FEATURE IN ... SHEET THE SHEET STRUCTURE OF THIS MOLECULE IS BIFURCATED. IN ORDER TO REPRESENT THIS FEATURE IN THE SHEET RECORDS BELOW, TWO SHEETS ARE DEFINED. |
-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 2vze.cif.gz | 300 KB | Display | PDBx/mmCIF format |
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PDB format | pdb2vze.ent.gz | 236.3 KB | Display | PDB format |
PDBx/mmJSON format | 2vze.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 2vze_validation.pdf.gz | 1.3 MB | Display | wwPDB validaton report |
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Full document | 2vze_full_validation.pdf.gz | 1.3 MB | Display | |
Data in XML | 2vze_validation.xml.gz | 56.3 KB | Display | |
Data in CIF | 2vze_validation.cif.gz | 83.8 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/vz/2vze ftp://data.pdbj.org/pub/pdb/validation_reports/vz/2vze | HTTPS FTP |
-Related structure data
Related structure data | 2wd9C 3b7wSC 3c5eC 3dayC 3eq6C 3gpcC S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Components on special symmetry positions |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Component-ID: 1
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