Entry Database : PDB / ID : 2vwe Structure visualization Downloads & linksTitle Crystal Structure of Vascular Endothelial Growth Factor-B in Complex with a Neutralizing Antibody Fab Fragment Components(ANTI-VEGF-B MONOCLONAL ANTIBODY) x 2 VASCULAR ENDOTHELIAL GROWTH FACTOR B DetailsKeywords IMMUNE SYSTEM / GLYCOPROTEIN / CYSTEINE-KNOT / GROWTH FACTOR / VEGF-B / MITOGEN / SECRETED / ANGIOGENESIS / NEUTRALIZING ANTIBODY / HEPARIN-BINDINGFunction / homology Function and homology informationFunction Domain/homology Component
positive regulation of vascular wound healing / vascular endothelial growth factor receptor 1 binding / VEGF ligand-receptor interactions / positive regulation of mast cell chemotaxis / VEGF binds to VEGFR leading to receptor dimerization / induction of positive chemotaxis / vascular endothelial growth factor receptor 2 binding / coronary vasculature development / protein O-linked glycosylation / positive regulation of vascular endothelial growth factor receptor signaling pathway ... positive regulation of vascular wound healing / vascular endothelial growth factor receptor 1 binding / VEGF ligand-receptor interactions / positive regulation of mast cell chemotaxis / VEGF binds to VEGFR leading to receptor dimerization / induction of positive chemotaxis / vascular endothelial growth factor receptor 2 binding / coronary vasculature development / protein O-linked glycosylation / positive regulation of vascular endothelial growth factor receptor signaling pathway / sprouting angiogenesis / vascular endothelial growth factor signaling pathway / chemoattractant activity / positive regulation of cell division / vascular endothelial growth factor receptor signaling pathway / cardiac muscle contraction / positive regulation of endothelial cell proliferation / platelet alpha granule lumen / growth factor activity / positive regulation of angiogenesis / positive regulation of peptidyl-tyrosine phosphorylation / Platelet degranulation / heparin binding / negative regulation of neuron apoptotic process / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / positive regulation of ERK1 and ERK2 cascade / response to hypoxia / positive regulation of protein phosphorylation / negative regulation of gene expression / negative regulation of apoptotic process / extracellular space / extracellular region / identical protein binding / membrane Similarity search - Function PDGF/VEGF domain / Platelet-derived growth factor, conserved site / PDGF/VEGF domain / Platelet-derived growth factor (PDGF) family signature. / Platelet-derived growth factor (PDGF) family profile. / Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family / Cystine Knot Cytokines, subunit B / Cystine-knot cytokines / Cystine-knot cytokine / Ribbon ... PDGF/VEGF domain / Platelet-derived growth factor, conserved site / PDGF/VEGF domain / Platelet-derived growth factor (PDGF) family signature. / Platelet-derived growth factor (PDGF) family profile. / Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family / Cystine Knot Cytokines, subunit B / Cystine-knot cytokines / Cystine-knot cytokine / Ribbon / Immunoglobulins / Immunoglobulin-like / Sandwich / Mainly Beta Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)MUS MUSCULUS (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 3.4 Å DetailsAuthors Leonard, P. / Scotney, P.D. / Jabeen, T. / Iyer, S. / Fabri, L.J. / Nash, A.D. / Acharya, K.R. CitationJournal : J.Mol.Biol. / Year : 2008Title : Crystal Structure of Vascular Endothelial Growth Factor-B in Complex with a Neutralising Antibody Fab Fragment.Authors : Leonard, P. / Scotney, P.D. / Jabeen, T. / Iyer, S. / Fabri, L.J. / Nash, A.D. / Acharya, K.R. History Deposition Jun 23, 2008 Deposition site : PDBE / Processing site : PDBERevision 1.0 Nov 4, 2008 Provider : repository / Type : Initial releaseRevision 1.1 May 8, 2011 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format complianceRevision 1.3 Dec 13, 2023 Group : Data collection / Database references ... Data collection / Database references / Other / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf
Show all Show less Remark 700 SHEET THE SHEET STRUCTURE OF THIS MOLECULE IS BIFURCATED. IN ORDER TO REPRESENT THIS FEATURE IN ... SHEET THE SHEET STRUCTURE OF THIS MOLECULE IS BIFURCATED. IN ORDER TO REPRESENT THIS FEATURE IN THE SHEET RECORDS BELOW, TWO SHEETS ARE DEFINED.