Entry Database : PDB / ID : 2vk3 Structure visualization Downloads & linksTitle Crystal structure of rat profilin 2a ComponentsPROFILIN-2 Details Keywords PROTEIN BINDING / PROFILIN / CYTOPLASM / ACETYLATION / CYTOSKELETON / ACTIN-BINDING / DISULFIDE BRIDGE / ALTERNATIVE SPLICING / PROTEIN-BINDINGFunction / homology Function and homology informationFunction Domain/homology Component
RHO GTPases Activate Formins / negative regulation of ruffle assembly / modification of postsynaptic actin cytoskeleton / negative regulation of epithelial cell migration / positive regulation of actin filament bundle assembly / negative regulation of actin filament polymerization / regulation of actin filament polymerization / positive regulation of ATP-dependent activity / regulation of synaptic vesicle exocytosis / positive regulation of actin filament polymerization ... RHO GTPases Activate Formins / negative regulation of ruffle assembly / modification of postsynaptic actin cytoskeleton / negative regulation of epithelial cell migration / positive regulation of actin filament bundle assembly / negative regulation of actin filament polymerization / regulation of actin filament polymerization / positive regulation of ATP-dependent activity / regulation of synaptic vesicle exocytosis / positive regulation of actin filament polymerization / actin monomer binding / positive regulation of stress fiber assembly / phosphatidylinositol-4,5-bisphosphate binding / Schaffer collateral - CA1 synapse / terminal bouton / positive regulation of peptidyl-serine phosphorylation / presynapse / actin binding / actin cytoskeleton organization / postsynapse / cytoskeleton / protein stabilization / glutamatergic synapse / ATP hydrolysis activity / cytoplasm Similarity search - Function Profilin-2 / Profilin1/2/3, vertebrate / Profilin conserved site / Profilin signature. / Profilin / Profilin / Profilin / Profilin superfamily / Dynein light chain 2a, cytoplasmic / Beta-Lactamase ... Profilin-2 / Profilin1/2/3, vertebrate / Profilin conserved site / Profilin signature. / Profilin / Profilin / Profilin / Profilin superfamily / Dynein light chain 2a, cytoplasmic / Beta-Lactamase / 2-Layer Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Rattus norvegicus (Norway rat)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.7 Å DetailsAuthors Haikarainen, T. / Kursula, P. CitationJournal : Acta Crystallogr.,Sect.D / Year : 2009Title : Structure, Modifications and Ligand-Binding Properties of Rat Profilin 2A.Authors : Haikarainen, T. / Chen, W.Q. / Lubec, G. / Kursula, P. History Deposition Dec 17, 2007 Deposition site : PDBE / Processing site : PDBERevision 1.0 Feb 10, 2009 Provider : repository / Type : Initial releaseRevision 1.1 May 8, 2011 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format complianceRevision 1.3 Mar 7, 2018 Group : Source and taxonomy / Category : entity_src_genItem : _entity_src_gen.pdbx_gene_src_scientific_name / _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id ... _entity_src_gen.pdbx_gene_src_scientific_name / _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id / _entity_src_gen.pdbx_host_org_scientific_name / _entity_src_gen.pdbx_host_org_strain / _entity_src_gen.pdbx_host_org_variant Revision 1.4 Jul 24, 2019 Group : Data collection / Derived calculations / Category : diffrn_source / struct_connItem : _diffrn_source.pdbx_synchrotron_site / _struct_conn.pdbx_leaving_atom_flagRevision 1.5 Dec 13, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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