Entry Database : PDB / ID : 2v58 Structure visualization Downloads & linksTitle CRYSTAL STRUCTURE OF BIOTIN CARBOXYLASE FROM E.COLI IN COMPLEX WITH POTENT INHIBITOR 1 ComponentsBIOTIN CARBOXYLASE Details Keywords LIGASE / FATTY ACID BIOSYNTHESIS / BIOTIN CARBOXYLASE / NUCLEOTIDE-BINDING / ATP-BINDING / ANTIBACTERIAL / LIPID SYNTHESIS / FAS / BIOTIN / BACTERIAL / INHIBITORFunction / homology Function and homology informationFunction Domain/homology Component
biotin carboxylase / acetyl-CoA carboxylase complex / biotin carboxylase activity / malonyl-CoA biosynthetic process / acetyl-CoA carboxylase activity / negative regulation of fatty acid biosynthetic process / fatty acid biosynthetic process / protein homodimerization activity / ATP binding / metal ion binding ... biotin carboxylase / acetyl-CoA carboxylase complex / biotin carboxylase activity / malonyl-CoA biosynthetic process / acetyl-CoA carboxylase activity / negative regulation of fatty acid biosynthetic process / fatty acid biosynthetic process / protein homodimerization activity / ATP binding / metal ion binding / cytoplasm / cytosol Similarity search - Function Acetyl-CoA carboxylase, biotin carboxylase / Biotin carboxylase-like, N-terminal domain / Biotin carboxylase, C-terminal / Biotin carboxylation domain / Biotin carboxylase, N-terminal domain / Biotin carboxylase C-terminal domain / Biotin carboxylation domain profile. / Biotin carboxylase C-terminal domain / Rossmann fold - #20 / Carbamoyl-phosphate synthase subdomain signature 1. ... Acetyl-CoA carboxylase, biotin carboxylase / Biotin carboxylase-like, N-terminal domain / Biotin carboxylase, C-terminal / Biotin carboxylation domain / Biotin carboxylase, N-terminal domain / Biotin carboxylase C-terminal domain / Biotin carboxylation domain profile. / Biotin carboxylase C-terminal domain / Rossmann fold - #20 / Carbamoyl-phosphate synthase subdomain signature 1. / Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain / Carbamoyl-phosphate synthase L chain, ATP binding domain / ATP-grasp fold, A domain / Rudiment single hybrid motif / ATP-grasp fold, B domain / ATP-grasp fold, subdomain 1 / Pre-ATP-grasp domain superfamily / ATP-grasp fold / ATP-grasp fold profile. / D-amino Acid Aminotransferase; Chain A, domain 1 / Dna Ligase; domain 1 / Carbamoyl-phosphate synthase subdomain signature 2. / Rossmann fold / 2-Layer Sandwich / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species ESCHERICHIA COLI (E. coli)Method X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution : 2.1 Å DetailsAuthors Mochalkin, I. / Miller, J.R. CitationJournal : Proc.Natl.Acad.Sci.USA / Year : 2009Title : A Class of Selective Antibacterials Derived from a Protein Kinase Inhibitor Pharmacophore.Authors: Miller, J.R. / Dunham, S. / Mochalkin, I. / Banotai, C. / Bowman, M. / Buist, S. / Dunkle, B. / Hanna, D. / Harwood, H.J. / Huband, M.D. / Karnovsky, A. / Kuhn, M. / Limberakis, C. / Liu, J. ... Authors : Miller, J.R. / Dunham, S. / Mochalkin, I. / Banotai, C. / Bowman, M. / Buist, S. / Dunkle, B. / Hanna, D. / Harwood, H.J. / Huband, M.D. / Karnovsky, A. / Kuhn, M. / Limberakis, C. / Liu, J.Y. / Mehrens, S. / Mueller, W.T. / Narasimhan, L. / Ogden, A. / Ohren, J. / Prasad, J.V. / Shelly, J.A. / Skerlos, L. / Sulavik, M. / Thomas, V.H. / Vanderroest, S. / Wang, L. / Wang, Z. / Whitton, A. / Zhu, T. / Stover, C.K. History Deposition Oct 2, 2008 Deposition site : PDBE / Processing site : PDBERevision 1.0 Jan 13, 2009 Provider : repository / Type : Initial releaseRevision 1.1 May 8, 2011 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format complianceRevision 1.3 Dec 13, 2023 Group : Data collection / Database references ... Data collection / Database references / Other / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf
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