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-Structure paper
Title | A Class of Selective Antibacterials Derived from a Protein Kinase Inhibitor Pharmacophore. |
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Journal, issue, pages | Proc. Natl. Acad. Sci. USA, Vol. 106, Page 1737-, Year 2009 |
Publish date | Oct 2, 2008 (structure data deposition date) |
Authors | Miller, J.R. / Dunham, S. / Mochalkin, I. / Banotai, C. / Bowman, M. / Buist, S. / Dunkle, B. / Hanna, D. / Harwood, H.J. / Huband, M.D. ...Miller, J.R. / Dunham, S. / Mochalkin, I. / Banotai, C. / Bowman, M. / Buist, S. / Dunkle, B. / Hanna, D. / Harwood, H.J. / Huband, M.D. / Karnovsky, A. / Kuhn, M. / Limberakis, C. / Liu, J.Y. / Mehrens, S. / Mueller, W.T. / Narasimhan, L. / Ogden, A. / Ohren, J. / Prasad, J.V. / Shelly, J.A. / Skerlos, L. / Sulavik, M. / Thomas, V.H. / Vanderroest, S. / Wang, L. / Wang, Z. / Whitton, A. / Zhu, T. / Stover, C.K. |
External links | Proc. Natl. Acad. Sci. USA / PubMed:19164768 |
Methods | X-ray diffraction |
Resolution | 2.1 - 2.4 Å |
Structure data | PDB-2v58: PDB-2v59: PDB-2v5a: |
Chemicals | ChemComp-LZJ: ChemComp-CL: ChemComp-HOH: ChemComp-LZK: ChemComp-LZL: |
Source |
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Keywords | LIGASE / FATTY ACID BIOSYNTHESIS / BIOTIN CARBOXYLASE / NUCLEOTIDE-BINDING / ATP-BINDING / ANTIBACTERIAL / LIPID SYNTHESIS / FAS / BIOTIN / BACTERIAL / INHIBITOR |