登録情報 | データベース: PDB / ID: 2rey |
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タイトル | Crystal structure of the PDZ domain of human dishevelled 2 (homologous to Drosophila dsh) |
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要素 | Segment polarity protein dishevelled homolog DVL-2 |
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キーワード | GENE REGULATION / PDZ / bound peptide / peptide binding site / Structural Genomics / Structural Genomics Consortium / SGC / Developmental protein / Phosphorylation / Wnt signaling pathway |
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機能・相同性 | 機能・相同性情報
Negative regulation of TCF-dependent signaling by DVL-interacting proteins / convergent extension involved in neural plate elongation / planar cell polarity pathway involved in neural tube closure / cochlea morphogenesis / segment specification / WNT5A-dependent internalization of FZD4 / non-canonical Wnt signaling pathway / positive regulation of neuron projection arborization / clathrin-coated endocytic vesicle / WNT5:FZD7-mediated leishmania damping ...Negative regulation of TCF-dependent signaling by DVL-interacting proteins / convergent extension involved in neural plate elongation / planar cell polarity pathway involved in neural tube closure / cochlea morphogenesis / segment specification / WNT5A-dependent internalization of FZD4 / non-canonical Wnt signaling pathway / positive regulation of neuron projection arborization / clathrin-coated endocytic vesicle / WNT5:FZD7-mediated leishmania damping / frizzled binding / PCP/CE pathway / Signaling by Hippo / WNT mediated activation of DVL / aggresome / Disassembly of the destruction complex and recruitment of AXIN to the membrane / Wnt signaling pathway, planar cell polarity pathway / heart looping / outflow tract morphogenesis / lateral plasma membrane / canonical Wnt signaling pathway / positive regulation of JUN kinase activity / Asymmetric localization of PCP proteins / TCF dependent signaling in response to WNT / neural tube closure / Degradation of DVL / RHO GTPases Activate Formins / regulation of actin cytoskeleton organization / positive regulation of JNK cascade / protein localization / small GTPase binding / positive regulation of DNA-binding transcription factor activity / : / Cargo recognition for clathrin-mediated endocytosis / apical part of cell / Clathrin-mediated endocytosis / protein-macromolecule adaptor activity / heart development / regulation of cell population proliferation / cytoplasmic vesicle / nuclear body / intracellular signal transduction / positive regulation of protein phosphorylation / protein domain specific binding / regulation of DNA-templated transcription / protein kinase binding / positive regulation of transcription by RNA polymerase II / nucleoplasm / identical protein binding / nucleus / cytoplasm / cytosol類似検索 - 分子機能 Dishevelled-2 / Dishevelled protein domain / Dishevelled family / Dishevelled C-terminal / Dishevelled specific domain / Segment polarity protein dishevelled (Dsh) C terminal / Dishevelled-related protein / DIX domain / DIX domain superfamily / DIX domain ...Dishevelled-2 / Dishevelled protein domain / Dishevelled family / Dishevelled C-terminal / Dishevelled specific domain / Segment polarity protein dishevelled (Dsh) C terminal / Dishevelled-related protein / DIX domain / DIX domain superfamily / DIX domain / DIX domain profile. / Domain present in Dishevelled and axin / Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) / DEP domain profile. / Domain found in Dishevelled, Egl-10, and Pleckstrin / DEP domain / PDZ domain / Pdz3 Domain / PDZ domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / Ubiquitin-like domain superfamily / Winged helix DNA-binding domain superfamily / Roll / Winged helix-like DNA-binding domain superfamily / Mainly Beta類似検索 - ドメイン・相同性 Segment polarity protein dishevelled homolog DVL-2類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.55 Å |
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データ登録者 | Papagrigoriou, E. / Gileadi, C. / Elkins, J. / Cooper, C. / Ugochukwu, E. / Turnbull, A. / Pike, A.C.W. / Gileadi, O. / von Delft, F. / Sundstrom, M. ...Papagrigoriou, E. / Gileadi, C. / Elkins, J. / Cooper, C. / Ugochukwu, E. / Turnbull, A. / Pike, A.C.W. / Gileadi, O. / von Delft, F. / Sundstrom, M. / Arrowsmith, C.H. / Weigelt, J. / Edwards, A.M. / Doyle, D. / Structural Genomics Consortium (SGC) |
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引用 | ジャーナル: To be Published タイトル: Crystal structure of the PDZ domains of human dishevelled 2 (homologous to Drosophila dsh). 著者: Papagrigoriou, E. / Gileadi, C. / Elkins, J. / Cooper, C. / Ugochukwu, E. / Turnbull, A. / Pike, A.C.W. / Gileadi, O. / von Delft, F. / Sundstrom, M. / Arrowsmith, C.H. / Weigelt, J. / Edwards, A.M. / Doyle, D. |
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履歴 | 登録 | 2007年9月27日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2007年10月23日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Advisory / Version format compliance |
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改定 1.2 | 2017年10月25日 | Group: Refinement description / カテゴリ: software / Item: _software.name |
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改定 1.3 | 2023年8月30日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details |
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