登録情報 データベース : PDB / ID : 2r9f 構造の表示 ダウンロードとリンクタイトル Calpain 1 proteolytic core inactivated by ZLAK-3002, an alpha-ketoamide 要素Calpain-1 catalytic subunit 詳細 キーワード HYDROLASE / PROTEASE / PEPTIDASE / INHIBITOR / ALPHA-KETOAMIDE / Membrane / Thiol protease機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
calpain-1 / Degradation of the extracellular matrix / protein catabolic process at postsynapse / positive regulation of leukocyte tethering or rolling / mammary gland involution / calcium-dependent cysteine-type endopeptidase activity / regulation of catalytic activity / negative regulation of actin filament polymerization / receptor catabolic process / self proteolysis ... calpain-1 / Degradation of the extracellular matrix / protein catabolic process at postsynapse / positive regulation of leukocyte tethering or rolling / mammary gland involution / calcium-dependent cysteine-type endopeptidase activity / regulation of catalytic activity / negative regulation of actin filament polymerization / receptor catabolic process / self proteolysis / cornified envelope / positive regulation of vascular permeability / response to arsenic-containing substance / negative regulation of non-canonical NF-kappaB signal transduction / response to angiotensin / Neutrophil degranulation / positive regulation of cardiac muscle cell apoptotic process / protein autoprocessing / cytoskeletal protein binding / protein catabolic process / cellular response to hydrogen peroxide / presynapse / peptidase activity / postsynapse / postsynaptic density / lysosome / glutamatergic synapse / calcium ion binding / enzyme binding / mitochondrion / proteolysis / membrane / plasma membrane / cytoplasm / cytosol 類似検索 - 分子機能 : / Calpain subdomain III / Peptidase C2, calpain, domain III / calpain_III / Peptidase C2, calpain, large subunit, domain III / Peptidase C2, calpain family / Calpain large subunit, domain III superfamily / Calpain large subunit, domain III / Peptidase C2, calpain, catalytic domain / Calpain family cysteine protease ... : / Calpain subdomain III / Peptidase C2, calpain, domain III / calpain_III / Peptidase C2, calpain, large subunit, domain III / Peptidase C2, calpain family / Calpain large subunit, domain III superfamily / Calpain large subunit, domain III / Peptidase C2, calpain, catalytic domain / Calpain family cysteine protease / Cysteine proteinase, calpain-type, catalytic domain profile. / Calpain-like thiol protease family. / EF-hand domain pair / Cysteine proteinases / Cysteine peptidase, cysteine active site / Eukaryotic thiol (cysteine) proteases cysteine active site. / Cathepsin B; Chain A / Papain-like cysteine peptidase superfamily / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / EF-hand domain / EF-hand domain pair / Alpha-Beta Complex / Alpha Beta 類似検索 - ドメイン・相同性生物種 Rattus norvegicus (ドブネズミ)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.6 Å 詳細データ登録者 Qian, J. / Campbell, R.L. / Davies, P.L. 引用ジャーナル : J.Med.Chem. / 年 : 2008タイトル : Cocrystal structures of primed side-extending alpha-ketoamide inhibitors reveal novel calpain-inhibitor aromatic interactions.著者 : Qian, J. / Cuerrier, D. / Davies, P.L. / Li, Z. / Powers, J.C. / Campbell, R.L. 履歴 登録 2007年9月12日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2008年8月26日 Provider : repository / タイプ : Initial release改定 1.1 2011年7月13日 Group : Non-polymer description / Version format compliance改定 1.2 2017年10月25日 Group : Advisory / Refinement description / カテゴリ : pdbx_unobs_or_zero_occ_atoms / software / Item : _software.name改定 1.3 2023年8月30日 Group : Advisory / Data collection ... Advisory / Data collection / Database references / Derived calculations / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_unobs_or_zero_occ_atoms / struct_conn / struct_conn_type / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn_type.id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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