登録情報 | データベース: PDB / ID: 2qui |
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タイトル | Crystal structures of human tryptophanyl-tRNA synthetase in complex with Tryptophanamide and ATP |
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要素 | Tryptophanyl-tRNA synthetase |
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キーワード | LIGASE / aminoacyl-tRNA synthetase / Rossmann fold / induced-fit mechnism / ATP-binding / Cytoplasm / Nucleotide-binding / Protein biosynthesis |
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機能・相同性 | 機能・相同性情報
tryptophan-tRNA ligase / tryptophan-tRNA ligase activity / tryptophanyl-tRNA aminoacylation / kinase inhibitor activity / Cytosolic tRNA aminoacylation / regulation of angiogenesis / negative regulation of protein kinase activity / positive regulation of protein-containing complex assembly / angiogenesis / translation ...tryptophan-tRNA ligase / tryptophan-tRNA ligase activity / tryptophanyl-tRNA aminoacylation / kinase inhibitor activity / Cytosolic tRNA aminoacylation / regulation of angiogenesis / negative regulation of protein kinase activity / positive regulation of protein-containing complex assembly / angiogenesis / translation / protein domain specific binding / negative regulation of cell population proliferation / positive regulation of gene expression / protein kinase binding / protein homodimerization activity / protein-containing complex / extracellular exosome / ATP binding / nucleus / cytoplasm / cytosol類似検索 - 分子機能 WHEP-TRS domain / WHEP-TRS domain / WHEP-TRS domain signature. / WHEP-TRS domain profile. / WHEP-TRS / Tryptophan-tRNA ligase / Tyrosyl-Transfer RNA Synthetase / Tyrosyl-Transfer RNA Synthetase / Aminoacyl-tRNA synthetase, class Ic / tRNA synthetases class I (W and Y) ...WHEP-TRS domain / WHEP-TRS domain / WHEP-TRS domain signature. / WHEP-TRS domain profile. / WHEP-TRS / Tryptophan-tRNA ligase / Tyrosyl-Transfer RNA Synthetase / Tyrosyl-Transfer RNA Synthetase / Aminoacyl-tRNA synthetase, class Ic / tRNA synthetases class I (W and Y) / Aminoacyl-tRNA synthetase, class I, conserved site / Aminoacyl-transfer RNA synthetases class-I signature. / HUPs / Rossmann-like alpha/beta/alpha sandwich fold / S15/NS1, RNA-binding / Rossmann fold / Orthogonal Bundle / 3-Layer(aba) Sandwich / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 ADENOSINE-5'-TRIPHOSPHATE / L-TRYPTOPHANAMIDE / Tryptophan--tRNA ligase, cytoplasmic類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.4 Å |
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データ登録者 | Shen, N. / Ding, J.P. |
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引用 | ジャーナル: Nucleic Acids Res. / 年: 2008 タイトル: Catalytic mechanism of the tryptophan activation reaction revealed by crystal structures of human tryptophanyl-tRNA synthetase in different enzymatic states 著者: Shen, N. / Zhou, M. / Yang, B. / Yu, Y. / Dong, X. / Ding, J. |
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履歴 | 登録 | 2007年8月5日 | 登録サイト: RCSB / 処理サイト: PDBJ |
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改定 1.0 | 2008年4月29日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Version format compliance |
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改定 1.2 | 2023年10月25日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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改定 1.3 | 2023年11月15日 | Group: Advisory / Other / カテゴリ: pdbx_validate_symm_contact / symmetry Item: _symmetry.Int_Tables_number / _symmetry.space_group_name_H-M |
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