Entry Database : PDB / ID : 2qme Structure visualization Downloads & linksTitle Crystal structure of human RAC3 in complex with CRIB domain of human p21-activated kinase 1 (PAK1) ComponentsCRIB domain of the Serine/threonine-protein kinase PAK 1 Ras-related C3 botulinum toxin substrate 3 DetailsKeywords SIGNALING PROTEIN/TRANSFERASE / GTPase RAC3 / small GTP binding protein / p21 rac / ras-related C3 botulinum toxin substrate 3 / signaling protein / CRIB / kinase / Structural Genomics / Structural Genomics Consortium / SGC / Cell projection / GTP-binding / Lipoprotein / Membrane / Methylation / Nucleotide-binding / Prenylation / Allosteric enzyme / ATP-binding / Phosphorylation / Serine/threonine-protein kinase / Transferase / Apoptosis / Cell junction / SIGNALING PROTEIN-TRANSFERASE COMPLEXFunction / homology Function and homology informationFunction Domain/homology Component
cerebral cortex GABAergic interneuron development / negative regulation of cell proliferation involved in contact inhibition / regulation of neuron maturation / protein localization to cytoplasmic stress granule / regulation of neutrophil migration / postsynaptic actin cytoskeleton organization / positive regulation of microtubule nucleation / engulfment of apoptotic cell / NADPH oxidase complex / respiratory burst ... cerebral cortex GABAergic interneuron development / negative regulation of cell proliferation involved in contact inhibition / regulation of neuron maturation / protein localization to cytoplasmic stress granule / regulation of neutrophil migration / postsynaptic actin cytoskeleton organization / positive regulation of microtubule nucleation / engulfment of apoptotic cell / NADPH oxidase complex / respiratory burst / cortical cytoskeleton organization / hepatocyte growth factor receptor signaling pathway / RHO GTPases Activate ROCKs / gamma-tubulin binding / cell projection assembly / synaptic transmission, GABAergic / motor neuron axon guidance / PCP/CE pathway / Activation of RAC1 / positive regulation of cell adhesion mediated by integrin / CD28 dependent Vav1 pathway / Ephrin signaling / positive regulation of intracellular estrogen receptor signaling pathway / RHOV GTPase cycle / establishment or maintenance of cell polarity / branching morphogenesis of an epithelial tube / regulation of axonogenesis / Fc-gamma receptor signaling pathway involved in phagocytosis / Rac protein signal transduction / RHOJ GTPase cycle / exocytosis / RHOQ GTPase cycle / filamentous actin / RHO GTPases activate PAKs / stimulatory C-type lectin receptor signaling pathway / regulation of MAPK cascade / CDC42 GTPase cycle / RHOU GTPase cycle / Sema3A PAK dependent Axon repulsion / neuromuscular process controlling balance / RHOH GTPase cycle / Generation of second messenger molecules / intercalated disc / Smooth Muscle Contraction / ephrin receptor signaling pathway / RAC2 GTPase cycle / RAC3 GTPase cycle / endomembrane system / positive regulation of substrate adhesion-dependent cell spreading / RHO GTPases activate PKNs / positive regulation of JUN kinase activity / homeostasis of number of cells within a tissue / positive regulation of stress fiber assembly / positive regulation of microtubule polymerization / ruffle / collagen binding / EPHB-mediated forward signaling / RAC1 GTPase cycle / CD209 (DC-SIGN) signaling / phosphorylation / cell chemotaxis / neuron projection morphogenesis / small monomeric GTPase / VEGFR2 mediated vascular permeability / G protein activity / Signal transduction by L1 / actin filament organization / cell periphery / actin filament / regulation of actin cytoskeleton organization / FCERI mediated MAPK activation / wound healing / MAPK6/MAPK4 signaling / G beta:gamma signalling through CDC42 / Regulation of actin dynamics for phagocytic cup formation / Wnt signaling pathway / ruffle membrane / Z disc / calcium-dependent protein binding / cell-cell junction / cell migration / positive regulation of peptidyl-serine phosphorylation / lamellipodium / chromosome / regulation of cell shape / growth cone / actin cytoskeleton organization / cytoplasmic vesicle / nuclear membrane / protein autophosphorylation / cytoskeleton / non-specific serine/threonine protein kinase / protein kinase activity / intracellular signal transduction / positive regulation of cell migration / neuron projection / chromatin remodeling / positive regulation of protein phosphorylation / axon / protein phosphorylation Similarity search - Function p21 activated kinase binding domain / : / CRIB domain superfamily / P21-Rho-binding domain / CRIB domain profile. / P21-Rho-binding domain / CRIB domain / Small GTPase Rho / small GTPase Rho family profile. / Rho (Ras homology) subfamily of Ras-like small GTPases ... p21 activated kinase binding domain / : / CRIB domain superfamily / P21-Rho-binding domain / CRIB domain profile. / P21-Rho-binding domain / CRIB domain / Small GTPase Rho / small GTPase Rho family profile. / Rho (Ras homology) subfamily of Ras-like small GTPases / Ras subfamily of RAS small GTPases / Small GTPase / Ras family / Rab subfamily of small GTPases / Small GTP-binding protein domain / P-loop containing nucleotide triphosphate hydrolases / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Rossmann fold / P-loop containing nucleoside triphosphate hydrolase / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homology PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER / Ras-related C3 botulinum toxin substrate 3 / Serine/threonine-protein kinase PAK 1 Similarity search - ComponentBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution : 1.75 Å DetailsAuthors Ugochukwu, E. / Yang, X. / Elkins, J.M. / Burgess-Brown, N. / Bunkoczi, G. / Sundstrom, M. / Arrowsmith, C.H. / Weigelt, J. / Edwards, A. / von Delft, F. ...Ugochukwu, E. / Yang, X. / Elkins, J.M. / Burgess-Brown, N. / Bunkoczi, G. / Sundstrom, M. / Arrowsmith, C.H. / Weigelt, J. / Edwards, A. / von Delft, F. / Knapp, S. / Doyle, D. / Structural Genomics Consortium (SGC) CitationJournal : To be Published Title : The crystal structure of the human RAC3 in complex with the CRIB domain of human p21-activated kinase 1 (PAK1).Authors : Ugochukwu, E. / Yang, X. / Elkins, J.M. / Burgess-Brown, N. / Bunkoczi, G. / Knapp, S. / Doyle, D. History Deposition Jul 16, 2007 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Aug 28, 2007 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2011 Group : Advisory / Version format complianceRevision 1.2 Aug 30, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr2_auth_seq_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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