Entry Database : PDB / ID : 2oza Structure visualization Downloads & linksTitle Structure of p38alpha complex ComponentsMAP kinase-activated protein kinase 2 Mitogen-activated protein kinase 14 DetailsKeywords SIGNALING PROTEIN/TRANSFERASE / SERINE/THREONINE KINASE / PROTEIN-PROTEIN COMPLEX / P38A / MK2 / SIGNALING PROTEIN-TRANSFERASE COMPLEXFunction / homology Function and homology informationFunction Domain/homology Component
macropinocytosis / CREB phosphorylation / Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA / DSCAM interactions / p38MAPK events / Activation of the AP-1 family of transcription factors / Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA / Platelet sensitization by LDL / RHO GTPases Activate NADPH Oxidases / leukotriene metabolic process ... macropinocytosis / CREB phosphorylation / Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA / DSCAM interactions / p38MAPK events / Activation of the AP-1 family of transcription factors / Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA / Platelet sensitization by LDL / RHO GTPases Activate NADPH Oxidases / leukotriene metabolic process / ERK/MAPK targets / activated TAK1 mediates p38 MAPK activation / Synthesis of Leukotrienes (LT) and Eoxins (EX) / calcium-dependent protein serine/threonine kinase activity / NOD1/2 Signaling Pathway / ADP signalling through P2Y purinoceptor 1 / Oxidative Stress Induced Senescence / Regulation of TP53 Activity through Phosphorylation / Myogenesis / regulation of tumor necrosis factor production / VEGFA-VEGFR2 Pathway / regulation of tumor necrosis factor-mediated signaling pathway / positive regulation of macrophage cytokine production / mitogen-activated protein kinase binding / regulation of interleukin-6 production / regulation of synaptic membrane adhesion / stress-induced premature senescence / cell surface receptor protein serine/threonine kinase signaling pathway / calcium/calmodulin-dependent protein kinase activity / 3'-UTR-mediated mRNA stabilization / toll-like receptor signaling pathway / cartilage condensation / cellular response to UV-B / mitogen-activated protein kinase p38 binding / positive regulation of myoblast fusion / negative regulation of hippo signaling / positive regulation of myotube differentiation / NFAT protein binding / glucose import / regulation of cytokine production involved in inflammatory response / p38MAPK cascade / fatty acid oxidation / cellular response to lipoteichoic acid / response to dietary excess / response to muramyl dipeptide / inner ear development / Regulation of HSF1-mediated heat shock response / MAP kinase activity / regulation of ossification / mitogen-activated protein kinase / cellular response to vascular endothelial growth factor stimulus / positive regulation of myoblast differentiation / chondrocyte differentiation / vascular endothelial growth factor receptor signaling pathway / regulation of cellular response to heat / stress-activated MAPK cascade / skeletal muscle tissue development / lipopolysaccharide-mediated signaling pathway / positive regulation of cardiac muscle cell proliferation / p38MAPK events / striated muscle cell differentiation / regulation of mRNA stability / response to muscle stretch / positive regulation of interleukin-12 production / positive regulation of brown fat cell differentiation / Neutrophil degranulation / osteoclast differentiation / positive regulation of erythrocyte differentiation / DNA damage checkpoint signaling / response to cytokine / activated TAK1 mediates p38 MAPK activation / cellular response to ionizing radiation / stem cell differentiation / positive regulation of glucose import / Regulation of TNFR1 signaling / response to insulin / bone development / negative regulation of canonical Wnt signaling pathway / placenta development / cell morphogenesis / cellular response to virus / VEGFA-VEGFR2 Pathway / spindle pole / positive regulation of protein import into nucleus / osteoblast differentiation / glucose metabolic process / positive regulation of tumor necrosis factor production / positive regulation of reactive oxygen species metabolic process / MAPK cascade / kinase activity / cellular response to tumor necrosis factor / cellular response to lipopolysaccharide / peptidyl-serine phosphorylation / protein phosphatase binding / angiogenesis / Oxidative Stress Induced Senescence / transcription by RNA polymerase II / response to lipopolysaccharide / non-specific serine/threonine protein kinase / calmodulin binding Similarity search - Function Protein kinase-like (PK-like) / MAP kinase activated protein kinase 2 / MAP kinase activated protein kinase, C-terminal / Mitogen-activated protein kinase 14 / Mitogen-activated protein (MAP) kinase p38-like / Mitogen-activated protein (MAP) kinase, conserved site / MAP kinase signature. / Few Secondary Structures / Irregular / Transferase(Phosphotransferase) domain 1 ... Protein kinase-like (PK-like) / MAP kinase activated protein kinase 2 / MAP kinase activated protein kinase, C-terminal / Mitogen-activated protein kinase 14 / Mitogen-activated protein (MAP) kinase p38-like / Mitogen-activated protein (MAP) kinase, conserved site / MAP kinase signature. / Few Secondary Structures / Irregular / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Mus musculus (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.7 Å DetailsAuthors White, A. / Pargellis, C.A. / Studts, J.M. / Werneburg, B.G. / Farmer II, B.T. CitationJournal : Proc.Natl.Acad.Sci.Usa / Year : 2007Title : Molecular basis of MAPK-activated protein kinase 2:p38 assemblyAuthors : White, A. / Pargellis, C.A. / Studts, J.M. / Werneburg, B.G. / Farmer II, B.T. History Deposition Feb 25, 2007 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Apr 3, 2007 Provider : repository / Type : Initial releaseRevision 1.1 May 1, 2008 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format complianceRevision 1.3 Feb 21, 2024 Group : Data collection / Database referencesCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / struct_ref_seq_dif Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details
Show all Show less