登録情報 データベース : PDB / ID : 2odd 構造の表示 ダウンロードとリンクタイトル Solution structure of the MYND domain from AML1-ETO complexed with SMRT, a corepressor 要素 詳細 キーワード METAL BINDING PROTEIN / MYND zinc finger / cross-braced topology / poly-proline / proline-tryptophan interaction機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
Loss of MECP2 binding ability to the NCoR/SMRT complex / negative regulation of androgen receptor signaling pathway / regulation of cellular ketone metabolic process / nuclear glucocorticoid receptor binding / Notch binding / NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis / negative regulation of fat cell differentiation / Notch-HLH transcription pathway / Regulation of MECP2 expression and activity / estrous cycle ... Loss of MECP2 binding ability to the NCoR/SMRT complex / negative regulation of androgen receptor signaling pathway / regulation of cellular ketone metabolic process / nuclear glucocorticoid receptor binding / Notch binding / NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis / negative regulation of fat cell differentiation / Notch-HLH transcription pathway / Regulation of MECP2 expression and activity / estrous cycle / nuclear retinoid X receptor binding / NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux / : / lactation / transcription repressor complex / Regulation of lipid metabolism by PPARalpha / cerebellum development / SUMOylation of transcription cofactors / negative regulation of miRNA transcription / HDACs deacetylate histones / Downregulation of SMAD2/3:SMAD4 transcriptional activity / PPARA activates gene expression / Cytoprotection by HMOX1 / NOTCH1 Intracellular Domain Regulates Transcription / Constitutive Signaling by NOTCH1 PEST Domain Mutants / Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants / nuclear matrix / histone deacetylase binding / Transcriptional regulation of white adipocyte differentiation / Nuclear Receptor transcription pathway / HCMV Early Events / transcription corepressor activity / response to estradiol / DNA-binding transcription factor binding / nuclear body / negative regulation of DNA-templated transcription / DNA-templated transcription / chromatin binding / chromatin / negative regulation of transcription by RNA polymerase II / DNA binding / nucleoplasm / membrane / nucleus / metal ion binding 類似検索 - 分子機能 Protein CBFA2T1 / CBFA2T family / NHR2-like / NHR2 domain like / Helix Hairpins - #2220 / N-CoR, GPS2-interacting domain / G-protein pathway suppressor 2-interacting domain / TAFH/NHR1 domain superfamily / NHR1 homology to TAF / TAFH/NHR1 domain profile. ... Protein CBFA2T1 / CBFA2T family / NHR2-like / NHR2 domain like / Helix Hairpins - #2220 / N-CoR, GPS2-interacting domain / G-protein pathway suppressor 2-interacting domain / TAFH/NHR1 domain superfamily / NHR1 homology to TAF / TAFH/NHR1 domain profile. / TAF homology / TAFH/NHR1 / MYND finger / Zinc finger, MYND-type / Zinc finger MYND-type signature. / Zinc finger MYND-type profile. / SANT domain profile. / SANT domain / Myb domain / Myb-like DNA-binding domain / Helix Hairpins / SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains / SANT/Myb domain / Helix non-globular / Homeobox-like domain superfamily / Special 類似検索 - ドメイン・相同性 Protein CBFA2T1 / Nuclear receptor corepressor 2 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 溶液NMR / simulated annealing , torsion angle dynamics 詳細データ登録者 Liu, Y.Z. / Chen, W. / Gaudet, J. / Cheney, M.D. / Roudaia, L. / Cierpicki, T. / Klet, R.C. / Hartman, K. / Laue, T.M. / Speck, N.A. / Bushweller, J.H. 引用ジャーナル : Cancer Cell / 年 : 2007タイトル : Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity.著者 : Liu, Y. / Chen, W. / Gaudet, J. / Cheney, M.D. / Roudaia, L. / Cierpicki, T. / Klet, R.C. / Hartman, K. / Laue, T.M. / Speck, N.A. / Bushweller, J.H. 履歴 登録 2006年12月22日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2007年6月19日 Provider : repository / タイプ : Initial release改定 1.1 2008年5月1日 Group : Version format compliance改定 1.2 2011年7月13日 Group : Version format compliance改定 1.3 2022年3月16日 Group : Database references / Derived calculationsカテゴリ : database_2 / pdbx_struct_assembly ... database_2 / pdbx_struct_assembly / pdbx_struct_conn_angle / pdbx_struct_oper_list / struct_conn / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id 改定 1.4 2023年12月27日 Group : Data collection / カテゴリ : chem_comp_atom / chem_comp_bond
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