gastric inhibitory polypeptide receptor binding / digestive system development / gastric inhibitory peptide signaling pathway / glucagon receptor binding / regulation of fatty acid biosynthetic process / endocrine pancreas development / positive regulation of cAMP-mediated signaling / response to lipid / Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) / response to selenium ion ...gastric inhibitory polypeptide receptor binding / digestive system development / gastric inhibitory peptide signaling pathway / glucagon receptor binding / regulation of fatty acid biosynthetic process / endocrine pancreas development / positive regulation of cAMP-mediated signaling / response to lipid / Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) / response to selenium ion / response to acidic pH / positive regulation of glucose transmembrane transport / triglyceride homeostasis / exploration behavior / response to starvation / regulation of insulin secretion / response to axon injury / response to amino acid / response to glucose / sensory perception of pain / adult locomotory behavior / female pregnancy / long-term synaptic potentiation / positive regulation of insulin secretion / adenylate cyclase-activating G protein-coupled receptor signaling pathway / hormone activity / response to organic cyclic compound / memory / response to peptide hormone / Glucagon-type ligand receptors / G alpha (s) signalling events / secretory granule lumen / response to xenobiotic stimulus / endoplasmic reticulum lumen / neuronal cell body / signal transduction / extracellular space / extracellular region 類似検索 - 分子機能
Single alpha-helices involved in coiled-coils or other helix-helix interfaces - #590 / Gastric inhibitory polypeptide / Glucagon/GIP/secretin/VIP / Peptide hormone / Glucagon / GIP / secretin / VIP family signature. / Glucagon like hormones / Single alpha-helices involved in coiled-coils or other helix-helix interfaces / Helix non-globular / Special 類似検索 - ドメイン・相同性
分子量: 4990.586 Da / 分子数: 1 / 断片: RESIDUES 52-93 / 由来タイプ: 合成 / 詳細: This sequence occurs naturally in humans, gene GIP / 参照: UniProt: P09681
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実験情報
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実験
実験
手法: 溶液NMR
NMR実験
Conditions-ID
Experiment-ID
Solution-ID
タイプ
1
1
1
DQF-COSY
1
2
1
2D TOCSY
1
3
1
2D NOESY
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試料調製
詳細
内容: GIP, 50% TFE-D3, 50% H2O
試料状態
pH: 3 / 圧: AMBIENT / 温度: 298 K
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NMR測定
NMRスペクトロメーター
タイプ
製造業者
モデル
磁場強度 (MHz)
Spectrometer-ID
Bruker DRX
Bruker
DRX
500
1
Bruker DRX
Bruker
DRX
800
2
Bruker DRX
Bruker
DRX
900
3
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解析
NMR software
名称
バージョン
開発者
分類
SYBYL
6.8.1
TRIPOS
精密化
XwinNMR
3.5
collection
XwinNMR
3.5
解析
Sparky
3.11
データ解析
CYANA
1.0.6
構造決定
精密化
手法: torsion angle dynamics / ソフトェア番号: 1 詳細: THE STRUCTURES ARE BASED ON A TOTAL OF 640 RESTRAINTS, 631 ARE NOE-DERIVED DISTANCE CONSTRAINTS, 9 DIHEDRAL ANGLE RESTRAINTS
NMRアンサンブル
コンフォーマー選択の基準: target function / 計算したコンフォーマーの数: 200 / 登録したコンフォーマーの数: 20