gastric inhibitory polypeptide receptor binding / digestive system development / gastric inhibitory peptide signaling pathway / glucagon receptor binding / regulation of fatty acid biosynthetic process / positive regulation of cAMP-mediated signaling / Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) / endocrine pancreas development / response to selenium ion / response to acidic pH ...gastric inhibitory polypeptide receptor binding / digestive system development / gastric inhibitory peptide signaling pathway / glucagon receptor binding / regulation of fatty acid biosynthetic process / positive regulation of cAMP-mediated signaling / Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) / endocrine pancreas development / response to selenium ion / response to acidic pH / positive regulation of glucose transmembrane transport / triglyceride homeostasis / exploration behavior / response to lipid / response to starvation / regulation of insulin secretion / response to axon injury / response to amino acid / response to glucose / sensory perception of pain / adult locomotory behavior / female pregnancy / long-term synaptic potentiation / adenylate cyclase-activating G protein-coupled receptor signaling pathway / positive regulation of insulin secretion / response to organic cyclic compound / hormone activity / memory / response to peptide hormone / Glucagon-type ligand receptors / G alpha (s) signalling events / secretory granule lumen / response to xenobiotic stimulus / endoplasmic reticulum lumen / neuronal cell body / signal transduction / extracellular space / extracellular region Similarity search - Function
Single alpha-helices involved in coiled-coils or other helix-helix interfaces - #590 / Gastric inhibitory polypeptide / Glucagon/GIP/secretin/VIP / Peptide hormone / Glucagon / GIP / secretin / VIP family signature. / Glucagon like hormones / Single alpha-helices involved in coiled-coils or other helix-helix interfaces / Helix non-globular / Special Similarity search - Domain/homology
Mass: 4990.586 Da / Num. of mol.: 1 / Fragment: RESIDUES 52-93 / Source method: obtained synthetically / Details: This sequence occurs naturally in humans, gene GIP / References: UniProt: P09681
-
Experimental details
-
Experiment
Experiment
Method: SOLUTION NMR
NMR experiment
Conditions-ID
Experiment-ID
Solution-ID
Type
1
1
1
DQF-COSY
1
2
1
2D TOCSY
1
3
1
2D NOESY
-
Sample preparation
Details
Contents: GIP, 50% TFE-D3, 50% H2O
Sample conditions
pH: 3.0 / Pressure: AMBIENT / Temperature: 298 K
-
NMR measurement
NMR spectrometer
Type
Manufacturer
Model
Field strength (MHz)
Spectrometer-ID
Bruker DRX
Bruker
DRX
500
1
Bruker DRX
Bruker
DRX
800
2
Bruker DRX
Bruker
DRX
900
3
-
Processing
NMR software
Name
Version
Developer
Classification
SYBYL
6.8.1
TRIPOS
refinement
XwinNMR
3.5
collection
XwinNMR
3.5
processing
Sparky
3.11
dataanalysis
CYANA
1.0.6
structuresolution
Refinement
Method: torsion angle dynamics / Software ordinal: 1 Details: THE STRUCTURES ARE BASED ON A TOTAL OF 640 RESTRAINTS, 631 ARE NOE-DERIVED DISTANCE CONSTRAINTS, 9 DIHEDRAL ANGLE RESTRAINTS
NMR ensemble
Conformer selection criteria: target function / Conformers calculated total number: 200 / Conformers submitted total number: 20
+
About Yorodumi
-
News
-
Feb 9, 2022. New format data for meta-information of EMDB entries
New format data for meta-information of EMDB entries
Version 3 of the EMDB header file is now the official format.
The previous official version 1.9 will be removed from the archive.
In the structure databanks used in Yorodumi, some data are registered as the other names, "COVID-19 virus" and "2019-nCoV". Here are the details of the virus and the list of structure data.
Jan 31, 2019. EMDB accession codes are about to change! (news from PDBe EMDB page)
EMDB accession codes are about to change! (news from PDBe EMDB page)
The allocation of 4 digits for EMDB accession codes will soon come to an end. Whilst these codes will remain in use, new EMDB accession codes will include an additional digit and will expand incrementally as the available range of codes is exhausted. The current 4-digit format prefixed with “EMD-” (i.e. EMD-XXXX) will advance to a 5-digit format (i.e. EMD-XXXXX), and so on. It is currently estimated that the 4-digit codes will be depleted around Spring 2019, at which point the 5-digit format will come into force.
The EM Navigator/Yorodumi systems omit the EMD- prefix.
Related info.:Q: What is EMD? / ID/Accession-code notation in Yorodumi/EM Navigator
Yorodumi is a browser for structure data from EMDB, PDB, SASBDB, etc.
This page is also the successor to EM Navigator detail page, and also detail information page/front-end page for Omokage search.
The word "yorodu" (or yorozu) is an old Japanese word meaning "ten thousand". "mi" (miru) is to see.
Related info.:EMDB / PDB / SASBDB / Comparison of 3 databanks / Yorodumi Search / Aug 31, 2016. New EM Navigator & Yorodumi / Yorodumi Papers / Jmol/JSmol / Function and homology information / Changes in new EM Navigator and Yorodumi