- PDB-2n8s: Solution Structure of the rNedd4 WW1 Domain by NMR -
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Basic information
Entry
Database: PDB / ID: 2n8s
Title
Solution Structure of the rNedd4 WW1 Domain by NMR
Components
E3 ubiquitin-protein ligase NEDD4
Keywords
LIGASE / rNedd4 WW1
Function / homology
Function and homology information
Downregulation of ERBB4 signaling / Regulation of PTEN localization / ISG15 antiviral mechanism / positive regulation of nucleocytoplasmic transport / Regulation of PTEN stability and activity / Antigen processing: Ubiquitination & Proteasome degradation / endocardial cushion development / negative regulation of sodium ion transport / response to denervation involved in regulation of muscle adaptation / regulation of protein catabolic process at postsynapse, modulating synaptic transmission ...Downregulation of ERBB4 signaling / Regulation of PTEN localization / ISG15 antiviral mechanism / positive regulation of nucleocytoplasmic transport / Regulation of PTEN stability and activity / Antigen processing: Ubiquitination & Proteasome degradation / endocardial cushion development / negative regulation of sodium ion transport / response to denervation involved in regulation of muscle adaptation / regulation of protein catabolic process at postsynapse, modulating synaptic transmission / nuclear receptor-mediated glucocorticoid signaling pathway / regulation protein catabolic process at postsynapse / phosphothreonine residue binding / receptor catabolic process / protein targeting to lysosome / ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway / HECT-type E3 ubiquitin transferase / sodium channel inhibitor activity / regulation of postsynaptic neurotransmitter receptor internalization / proline-rich region binding / regulation of monoatomic ion transmembrane transport / RNA polymerase binding / blood vessel morphogenesis / postsynaptic cytosol / lysosomal transport / neuromuscular junction development / sodium ion transport / regulation of dendrite morphogenesis / regulation of synapse organization / negative regulation of vascular endothelial growth factor receptor signaling pathway / outflow tract morphogenesis / progesterone receptor signaling pathway / protein monoubiquitination / microvillus / protein K63-linked ubiquitination / phosphoserine residue binding / beta-2 adrenergic receptor binding / ubiquitin ligase complex / T cell activation / ubiquitin binding / establishment of localization in cell / regulation of membrane potential / ionotropic glutamate receptor binding / receptor internalization / positive regulation of protein catabolic process / ubiquitin-protein transferase activity / cellular response to UV / neuron projection development / ubiquitin protein ligase activity / cell cortex / ubiquitin-dependent protein catabolic process / adaptive immune response / dendritic spine / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / protein ubiquitination / immune response / protein domain specific binding / innate immune response / glutamatergic synapse / DNA damage response / chromatin / perinuclear region of cytoplasm / Golgi apparatus / enzyme binding / negative regulation of transcription by RNA polymerase II / protein-containing complex / membrane / nucleus / plasma membrane / cytoplasm / cytosol Similarity search - Function
E3 ubiquitin-protein ligase, SMURF1 type / HECT domain / HECT, E3 ligase catalytic domain / HECT-domain (ubiquitin-transferase) / HECT domain profile. / Domain Homologous to E6-AP Carboxyl Terminus with / C2 domain / Protein kinase C conserved region 2 (CalB) / WW domain / WW/rsp5/WWP domain signature. ...E3 ubiquitin-protein ligase, SMURF1 type / HECT domain / HECT, E3 ligase catalytic domain / HECT-domain (ubiquitin-transferase) / HECT domain profile. / Domain Homologous to E6-AP Carboxyl Terminus with / C2 domain / Protein kinase C conserved region 2 (CalB) / WW domain / WW/rsp5/WWP domain signature. / C2 domain / C2 domain profile. / WW domain superfamily / WW/rsp5/WWP domain profile. / Domain with 2 conserved Trp (W) residues / WW domain / C2 domain superfamily Similarity search - Domain/homology
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