登録情報 | データベース: PDB / ID: 2n83 |
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タイトル | p75NTR DD:RIP2 CARD |
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要素 | - Receptor-interacting serine/threonine-protein kinase 2
- Tumor necrosis factor receptor superfamily member 16
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キーワード | SIGNALING PROTEIN/TRANSFERASE / RIP2 CARD / p75NTR / death domain / SIGNALING PROTEIN-TRANSFERASE complex |
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機能・相同性 | 機能・相同性情報
NFG and proNGF binds to p75NTR / detection of temperature stimulus / dorsal aorta development / Ceramide signalling / death receptor activity / positive regulation of odontogenesis of dentin-containing tooth / response to interleukin-18 / negative regulation of hair follicle development / positive regulation of T-helper 1 cell differentiation / toll-like receptor 2 signaling pathway ...NFG and proNGF binds to p75NTR / detection of temperature stimulus / dorsal aorta development / Ceramide signalling / death receptor activity / positive regulation of odontogenesis of dentin-containing tooth / response to interleukin-18 / negative regulation of hair follicle development / positive regulation of T-helper 1 cell differentiation / toll-like receptor 2 signaling pathway / negative regulation of fibroblast growth factor receptor signaling pathway / p75NTR negatively regulates cell cycle via SC1 / negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis / positive regulation of cytokine-mediated signaling pathway / neurotrophin binding / immature T cell proliferation in thymus / positive regulation of T-helper 1 type immune response / positive regulation of xenophagy / LIM domain binding / xenophagy / CD4-positive, alpha-beta T cell proliferation / nucleotide-binding oligomerization domain containing 1 signaling pathway / positive regulation of protein K63-linked ubiquitination / positive regulation of stress-activated MAPK cascade / nerve development / cellular response to muramyl dipeptide / Axonal growth inhibition (RHOA activation) / Axonal growth stimulation / CARD domain binding / positive regulation of immature T cell proliferation in thymus / caspase binding / JUN kinase kinase kinase activity / nerve growth factor binding / NADE modulates death signalling / cellular response to peptidoglycan / response to interleukin-12 / positive regulation of CD4-positive, alpha-beta T cell proliferation / Regulated proteolysis of p75NTR / activation of cysteine-type endopeptidase activity / nucleotide-binding oligomerization domain containing 2 signaling pathway / positive regulation of macrophage cytokine production / toll-like receptor 4 signaling pathway / hair follicle morphogenesis / NRAGE signals death through JNK / response to exogenous dsRNA / intracellular glucose homeostasis / odontogenesis of dentin-containing tooth / cellular response to lipoteichoic acid / Rho protein signal transduction / canonical NF-kappaB signal transduction / fibroblast growth factor receptor signaling pathway / positive regulation of interferon-alpha production / coreceptor activity / signaling adaptor activity / positive regulation of chemokine production / stress-activated MAPK cascade / JNK cascade / lipopolysaccharide-mediated signaling pathway / p75NTR recruits signalling complexes / presynaptic modulation of chemical synaptic transmission / positive regulation of interleukin-12 production / ERK1 and ERK2 cascade / positive regulation of interleukin-2 production / positive regulation of interferon-beta production / NF-kB is activated and signals survival / NRIF signals cell death from the nucleus / response to interleukin-1 / negative regulation of cell migration / JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 / positive regulation of peptidyl-threonine phosphorylation / positive regulation of interleukin-1 beta production / positive regulation of protein ubiquitination / central nervous system development / activated TAK1 mediates p38 MAPK activation / positive regulation of apoptotic signaling pathway / positive regulation of JNK cascade / axon guidance / non-specific protein-tyrosine kinase / intracellular protein transport / circadian regulation of gene expression / TAK1-dependent IKK and NF-kappa-B activation / non-membrane spanning protein tyrosine kinase activity / NOD1/2 Signaling Pathway / neuromuscular junction / protein homooligomerization / small GTPase binding / cytokine-mediated signaling pathway / positive regulation of miRNA transcription / positive regulation of protein localization to nucleus / Interleukin-1 signaling / cellular response to amyloid-beta / transmembrane signaling receptor activity / activation of cysteine-type endopeptidase activity involved in apoptotic process / positive regulation of interleukin-6 production / positive regulation of tumor necrosis factor production / positive regulation of peptidyl-tyrosine phosphorylation / positive regulation of type II interferon production / positive regulation of fibroblast proliferation / cell-cell junction / Ovarian tumor domain proteases類似検索 - 分子機能 Tumour necrosis factor receptor 16 / Tumor necrosis factor receptor 16, N-terminal / Tumor necrosis factor receptor member 16, transmembrane domain / Tumor necrosis factor receptor member 16 trans-membrane domain / Receptor-interacting serine/threonine-protein kinase 2 / RIP2, CARD domain / Death Domain, Fas / Death Domain, Fas / TNFR/NGFR family cysteine-rich region domain profile. / TNFR/NGFR cysteine-rich region ...Tumour necrosis factor receptor 16 / Tumor necrosis factor receptor 16, N-terminal / Tumor necrosis factor receptor member 16, transmembrane domain / Tumor necrosis factor receptor member 16 trans-membrane domain / Receptor-interacting serine/threonine-protein kinase 2 / RIP2, CARD domain / Death Domain, Fas / Death Domain, Fas / TNFR/NGFR family cysteine-rich region domain profile. / TNFR/NGFR cysteine-rich region / TNFR/NGFR family cysteine-rich region signature. / Tumor necrosis factor receptor / nerve growth factor receptor repeats. / TNFR/NGFR cysteine-rich region / Death domain profile. / CARD domain / CARD caspase recruitment domain profile. / Caspase recruitment domain / DEATH domain, found in proteins involved in cell death (apoptosis). / Death domain / Death domain / Death-like domain superfamily / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 Receptor-interacting serine/threonine-protein kinase 2 / Tumor necrosis factor receptor superfamily member 16類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 溶液NMR / molecular dynamics |
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Model details | lowest energy, model1 |
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データ登録者 | Lin, Z. / Ibanez, C.F. |
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引用 | ジャーナル: Elife / 年: 2015 タイトル: Structural basis of death domain signaling in the p75 neurotrophin receptor 著者: Lin, Z. / Tann, J.Y. / Goh, E.T. / Kelly, C. / Lim, K.B. / Gao, J.F. / Ibanez, C.F. |
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履歴 | 登録 | 2015年10月2日 | 登録サイト: BMRB / 処理サイト: PDBJ |
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改定 1.0 | 2015年12月23日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2016年4月27日 | Group: Structure summary |
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改定 1.2 | 2024年5月1日 | Group: Data collection / Database references カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_nmr_software / pdbx_nmr_spectrometer Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_software.name / _pdbx_nmr_spectrometer.model |
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