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Open data
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Basic information
Entry | Database: PDB / ID: 2n83 | ||||||
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Title | p75NTR DD:RIP2 CARD | ||||||
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![]() | SIGNALING PROTEIN/TRANSFERASE / RIP2 CARD / p75NTR / death domain / SIGNALING PROTEIN-TRANSFERASE complex | ||||||
Function / homology | ![]() NFG and proNGF binds to p75NTR / detection of temperature stimulus / dorsal aorta development / Ceramide signalling / death receptor activity / positive regulation of odontogenesis of dentin-containing tooth / response to interleukin-18 / negative regulation of hair follicle development / positive regulation of T-helper 1 cell differentiation / toll-like receptor 2 signaling pathway ...NFG and proNGF binds to p75NTR / detection of temperature stimulus / dorsal aorta development / Ceramide signalling / death receptor activity / positive regulation of odontogenesis of dentin-containing tooth / response to interleukin-18 / negative regulation of hair follicle development / positive regulation of T-helper 1 cell differentiation / toll-like receptor 2 signaling pathway / negative regulation of fibroblast growth factor receptor signaling pathway / p75NTR negatively regulates cell cycle via SC1 / negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis / positive regulation of cytokine-mediated signaling pathway / neurotrophin binding / immature T cell proliferation in thymus / positive regulation of T-helper 1 type immune response / positive regulation of xenophagy / LIM domain binding / xenophagy / CD4-positive, alpha-beta T cell proliferation / nucleotide-binding oligomerization domain containing 1 signaling pathway / positive regulation of protein K63-linked ubiquitination / positive regulation of stress-activated MAPK cascade / nerve development / cellular response to muramyl dipeptide / Axonal growth inhibition (RHOA activation) / Axonal growth stimulation / CARD domain binding / positive regulation of immature T cell proliferation in thymus / caspase binding / JUN kinase kinase kinase activity / nerve growth factor binding / NADE modulates death signalling / cellular response to peptidoglycan / response to interleukin-12 / positive regulation of CD4-positive, alpha-beta T cell proliferation / Regulated proteolysis of p75NTR / activation of cysteine-type endopeptidase activity / nucleotide-binding oligomerization domain containing 2 signaling pathway / positive regulation of macrophage cytokine production / toll-like receptor 4 signaling pathway / hair follicle morphogenesis / NRAGE signals death through JNK / response to exogenous dsRNA / intracellular glucose homeostasis / odontogenesis of dentin-containing tooth / cellular response to lipoteichoic acid / Rho protein signal transduction / canonical NF-kappaB signal transduction / fibroblast growth factor receptor signaling pathway / positive regulation of interferon-alpha production / coreceptor activity / signaling adaptor activity / positive regulation of chemokine production / stress-activated MAPK cascade / JNK cascade / lipopolysaccharide-mediated signaling pathway / p75NTR recruits signalling complexes / presynaptic modulation of chemical synaptic transmission / positive regulation of interleukin-12 production / ERK1 and ERK2 cascade / positive regulation of interleukin-2 production / positive regulation of interferon-beta production / NF-kB is activated and signals survival / NRIF signals cell death from the nucleus / response to interleukin-1 / negative regulation of cell migration / JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 / positive regulation of peptidyl-threonine phosphorylation / positive regulation of interleukin-1 beta production / positive regulation of protein ubiquitination / central nervous system development / activated TAK1 mediates p38 MAPK activation / positive regulation of apoptotic signaling pathway / positive regulation of JNK cascade / axon guidance / non-specific protein-tyrosine kinase / intracellular protein transport / circadian regulation of gene expression / TAK1-dependent IKK and NF-kappa-B activation / non-membrane spanning protein tyrosine kinase activity / NOD1/2 Signaling Pathway / neuromuscular junction / protein homooligomerization / small GTPase binding / cytokine-mediated signaling pathway / positive regulation of miRNA transcription / positive regulation of protein localization to nucleus / Interleukin-1 signaling / cellular response to amyloid-beta / transmembrane signaling receptor activity / activation of cysteine-type endopeptidase activity involved in apoptotic process / positive regulation of interleukin-6 production / positive regulation of tumor necrosis factor production / positive regulation of peptidyl-tyrosine phosphorylation / positive regulation of type II interferon production / positive regulation of fibroblast proliferation / cell-cell junction / Ovarian tumor domain proteases Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | SOLUTION NMR / molecular dynamics | ||||||
Model details | lowest energy, model1 | ||||||
![]() | Lin, Z. / Ibanez, C.F. | ||||||
![]() | ![]() Title: Structural basis of death domain signaling in the p75 neurotrophin receptor Authors: Lin, Z. / Tann, J.Y. / Goh, E.T. / Kelly, C. / Lim, K.B. / Gao, J.F. / Ibanez, C.F. | ||||||
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 611.5 KB | Display | ![]() |
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PDB format | ![]() | 515.8 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
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-Validation report
Summary document | ![]() | 439.9 KB | Display | ![]() |
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Full document | ![]() | 558.8 KB | Display | |
Data in XML | ![]() | 39 KB | Display | |
Data in CIF | ![]() | 53.4 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 2n7zC ![]() 2n80C ![]() 2n97C C: citing same article ( |
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Similar structure data | |
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Assembly
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NMR ensembles |
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Components
#1: Protein | Mass: 10530.701 Da / Num. of mol.: 1 / Fragment: UNP residues 334-427 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() |
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#2: Protein | Mass: 12116.883 Da / Num. of mol.: 1 / Fragment: UNP residues 435-539 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() References: UniProt: O43353, non-specific serine/threonine protein kinase, non-specific protein-tyrosine kinase |
-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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NMR experiment |
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Sample preparation
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Sample |
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Sample conditions | Pressure: ambient atm / Temperature: 301 K |
-NMR measurement
NMR spectrometer | Type: Bruker Avance / Manufacturer: Bruker / Model: AVANCE / Field strength: 800 MHz |
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Processing
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Refinement | Method: molecular dynamics / Software ordinal: 1 | |||||||||||||||
NMR representative | Selection criteria: lowest energy | |||||||||||||||
NMR ensemble | Conformer selection criteria: structures with the lowest energy Conformers calculated total number: 100 / Conformers submitted total number: 10 / Representative conformer: 1 |