- PDB-2mw5: Backbone fold of Human Small Ubiquitin like Modifier protein-1 (S... -
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Basic information
Entry
Database: PDB / ID: 2mw5
Title
Backbone fold of Human Small Ubiquitin like Modifier protein-1 (SUMO-1) based on Prot3D-NMR approach.
Components
Small ubiquitin-related modifier 1
Keywords
PROTEIN BINDING / human SUMO / Small Ubiquitin like Modifier / SUMO-1
Function / homology
Function and homology information
protein localization to nuclear pore / negative regulation of transcription by transcription factor localization / SUMOylation of nuclear envelope proteins / Negative regulation of activity of TFAP2 (AP-2) family transcription factors / SUMO is proteolytically processed / negative regulation of delayed rectifier potassium channel activity / SUMO is conjugated to E1 (UBA2:SAE1) / nuclear stress granule / PML body organization / SUMO is transferred from E1 to E2 (UBE2I, UBC9) ...protein localization to nuclear pore / negative regulation of transcription by transcription factor localization / SUMOylation of nuclear envelope proteins / Negative regulation of activity of TFAP2 (AP-2) family transcription factors / SUMO is proteolytically processed / negative regulation of delayed rectifier potassium channel activity / SUMO is conjugated to E1 (UBA2:SAE1) / nuclear stress granule / PML body organization / SUMO is transferred from E1 to E2 (UBE2I, UBC9) / negative regulation of action potential / small protein activating enzyme binding / septin ring / regulation of calcium ion transmembrane transport / SUMOylation of DNA methylation proteins / SUMOylation of immune response proteins / XY body / SUMOylation of SUMOylation proteins / Maturation of nucleoprotein / SUMOylation of RNA binding proteins / regulation of cardiac muscle cell contraction / Postmitotic nuclear pore complex (NPC) reformation / Maturation of nucleoprotein / negative regulation of protein import into nucleus / roof of mouth development / SUMOylation of ubiquitinylation proteins / ubiquitin-specific protease binding / negative regulation of DNA binding / ubiquitin-like protein ligase binding / SUMOylation of DNA replication proteins / transcription factor binding / SUMOylation of transcription factors / protein sumoylation / potassium channel regulator activity / SUMOylation of DNA damage response and repair proteins / Regulation of IFNG signaling / nuclear pore / cellular response to cadmium ion / SUMOylation of chromatin organization proteins / SUMOylation of transcription cofactors / SUMOylation of intracellular receptors / positive regulation of protein-containing complex assembly / PKR-mediated signaling / negative regulation of DNA-binding transcription factor activity / PML body / Formation of Incision Complex in GG-NER / protein tag activity / regulation of protein localization / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks / cellular response to heat / nuclear membrane / nuclear body / protein stabilization / nuclear speck / DNA repair / negative regulation of DNA-templated transcription / ubiquitin protein ligase binding / nucleolus / enzyme binding / RNA binding / nucleoplasm / nucleus / plasma membrane / cytosol Similarity search - Function
Type: Bruker Avance / Manufacturer: Bruker / Model: AVANCE / Field strength: 800 MHz
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Processing
NMR software
Name
Version
Developer
Classification
CARA
9.8
KellerandWuthrich
chemicalshiftassignment
CYANA
refinement
Refinement
Method: distance geometry / Software ordinal: 1
NMR constraints
NOE constraints total: 509 / NOE long range total count: 122 / Protein phi angle constraints total count: 66 / Protein psi angle constraints total count: 66
NMR representative
Selection criteria: lowest energy
NMR ensemble
Average torsion angle constraint violation: 3.73 ° / Conformer selection criteria: target function / Conformers calculated total number: 200 / Conformers submitted total number: 10 / Maximum lower distance constraint violation: 5 Å / Maximum torsion angle constraint violation: 6.9 ° / Maximum upper distance constraint violation: 7 Å / Representative conformer: 1 / Torsion angle constraint violation method: Talos Plus
NMR ensemble rms
Distance rms dev: 0.66 Å / Distance rms dev error: 0.13 Å
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