+データを開く
-基本情報
登録情報 | データベース: PDB / ID: 2mse | ||||||
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タイトル | NMR data-driven model of GTPase KRas-GNP:ARafRBD complex tethered to a lipid-bilayer nanodisc | ||||||
要素 |
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キーワード | LIPID BINDING PROTEIN / K-Ras / Nanodisc / PRE / Docking / A-RafRBD | ||||||
機能・相同性 | 機能・相同性情報 endocrine signaling / cellular response to lipoprotein particle stimulus / Defective ABCA1 causes TGD / high-density lipoprotein particle receptor binding / Scavenging by Class B Receptors / HDL clearance / apolipoprotein receptor binding / spherical high-density lipoprotein particle / positive regulation of hydrolase activity / regulation of intestinal cholesterol absorption ...endocrine signaling / cellular response to lipoprotein particle stimulus / Defective ABCA1 causes TGD / high-density lipoprotein particle receptor binding / Scavenging by Class B Receptors / HDL clearance / apolipoprotein receptor binding / spherical high-density lipoprotein particle / positive regulation of hydrolase activity / regulation of intestinal cholesterol absorption / negative regulation of response to cytokine stimulus / protein oxidation / vitamin transport / cholesterol import / high-density lipoprotein particle binding / HDL assembly / negative regulation of heterotypic cell-cell adhesion / blood vessel endothelial cell migration / ABC transporters in lipid homeostasis / apolipoprotein A-I receptor binding / negative regulation of cytokine production involved in immune response / negative regulation of cell adhesion molecule production / negative regulation of very-low-density lipoprotein particle remodeling / peptidyl-methionine modification / phosphatidylcholine biosynthetic process / glucocorticoid metabolic process / acylglycerol homeostasis / Chylomicron remodeling / phosphatidylcholine-sterol O-acyltransferase activator activity / positive regulation of phospholipid efflux / Chylomicron assembly / positive regulation of cholesterol metabolic process / lipid storage / high-density lipoprotein particle clearance / chylomicron / phospholipid homeostasis / high-density lipoprotein particle remodeling / phospholipid efflux / cholesterol transfer activity / chemorepellent activity / reverse cholesterol transport / high-density lipoprotein particle assembly / cholesterol transport / very-low-density lipoprotein particle / low-density lipoprotein particle / lipoprotein biosynthetic process / positive regulation of CoA-transferase activity / high-density lipoprotein particle / regulation of Cdc42 protein signal transduction / triglyceride homeostasis / HDL remodeling / endothelial cell proliferation / forebrain astrocyte development / Scavenging by Class A Receptors / cholesterol efflux / negative regulation of interleukin-1 beta production / positive regulation of Rho protein signal transduction / negative regulation of epithelial cell differentiation / adrenal gland development / regulation of synaptic transmission, GABAergic / negative chemotaxis / cholesterol binding / epithelial tube branching involved in lung morphogenesis / type I pneumocyte differentiation / Rac protein signal transduction / cholesterol biosynthetic process / positive regulation of Rac protein signal transduction / skeletal muscle cell differentiation / Signaling by RAS GAP mutants / Signaling by RAS GTPase mutants / Activation of RAS in B cells / endocytic vesicle / RAS signaling downstream of NF1 loss-of-function variants / RUNX3 regulates p14-ARF / SOS-mediated signalling / Activated NTRK3 signals through RAS / Activated NTRK2 signals through RAS / SHC1 events in ERBB4 signaling / negative regulation of tumor necrosis factor-mediated signaling pathway / positive regulation of cholesterol efflux / Signalling to RAS / SHC-related events triggered by IGF1R / glial cell proliferation / Activated NTRK2 signals through FRS2 and FRS3 / SHC-mediated cascade:FGFR2 / Estrogen-stimulated signaling through PRKCZ / SHC-mediated cascade:FGFR3 / MET activates RAS signaling / Scavenging of heme from plasma / Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants / Signaling by PDGFRA extracellular domain mutants / PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases / SHC-mediated cascade:FGFR4 / Signaling by FGFR4 in disease / Erythropoietin activates RAS / Signaling by CSF3 (G-CSF) / SHC-mediated cascade:FGFR1 / positive regulation of substrate adhesion-dependent cell spreading / Retinoid metabolism and transport / positive regulation of phagocytosis 類似検索 - 分子機能 | ||||||
生物種 | Homo sapiens (ヒト) | ||||||
手法 | 溶液NMR / simulated annealing | ||||||
データ登録者 | Mazhab-Jafari, M. / Stathopoulos, P. / Marshall, C. / Ikura, M. | ||||||
引用 | ジャーナル: Proc.Natl.Acad.Sci.USA / 年: 2015 タイトル: Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site. 著者: Mazhab-Jafari, M.T. / Marshall, C.B. / Smith, M.J. / Gasmi-Seabrook, G.M. / Stathopulos, P.B. / Inagaki, F. / Kay, L.E. / Neel, B.G. / Ikura, M. | ||||||
履歴 |
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-構造の表示
構造ビューア | 分子: MolmilJmol/JSmol |
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-ダウンロードとリンク
-ダウンロード
PDBx/mmCIF形式 | 2mse.cif.gz | 1.9 MB | 表示 | PDBx/mmCIF形式 |
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PDB形式 | pdb2mse.ent.gz | 1.6 MB | 表示 | PDB形式 |
PDBx/mmJSON形式 | 2mse.json.gz | ツリー表示 | PDBx/mmJSON形式 | |
その他 | その他のダウンロード |
-検証レポート
文書・要旨 | 2mse_validation.pdf.gz | 3.3 MB | 表示 | wwPDB検証レポート |
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文書・詳細版 | 2mse_full_validation.pdf.gz | 3.7 MB | 表示 | |
XML形式データ | 2mse_validation.xml.gz | 536.8 KB | 表示 | |
CIF形式データ | 2mse_validation.cif.gz | 623.6 KB | 表示 | |
アーカイブディレクトリ | https://data.pdbj.org/pub/pdb/validation_reports/ms/2mse ftp://data.pdbj.org/pub/pdb/validation_reports/ms/2mse | HTTPS FTP |
-関連構造データ
-リンク
-集合体
登録構造単位 |
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NMR アンサンブル |
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-要素
-タンパク質 , 3種, 4分子 ACBD
#1: タンパク質 | 分子量: 23234.295 Da / 分子数: 2 / 断片: UNP residues 68-265 / 由来タイプ: 組換発現 / 由来: (組換発現) Homo sapiens (ヒト) / 遺伝子: APOA1 / プラスミド: pGBHPS MSP / 発現宿主: Escherichia coli (大腸菌) / 参照: UniProt: P02647 #2: タンパク質 | | 分子量: 21260.250 Da / 分子数: 1 / 断片: UNP residues 1-185 / 由来タイプ: 組換発現 / 由来: (組換発現) Homo sapiens (ヒト) / 遺伝子: KRAS, KRAS2, RASK2 / プラスミド: pET-28 / 発現宿主: Escherichia coli (大腸菌) / 参照: UniProt: P01116, UniProt: A0A024RAV5*PLUS #3: タンパク質 | | 分子量: 8133.491 Da / 分子数: 1 / 断片: UNP residues 19-91 / 由来タイプ: 組換発現 / 由来: (組換発現) Homo sapiens (ヒト) / 遺伝子: ARAF, ARAF1, PKS, PKS2 / プラスミド: pGEX-4TpGEX-4T22 / 発現宿主: Escherichia coli (大腸菌) 参照: UniProt: P10398, non-specific serine/threonine protein kinase |
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-非ポリマー , 4種, 82分子
#4: 化合物 | ChemComp-PCW / #5: 化合物 | ChemComp-17F / #6: 化合物 | ChemComp-GNP / | #7: 化合物 | ChemComp-MG / | |
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-実験情報
-実験
実験 | 手法: 溶液NMR 詳細: This is a hybrid model generated by Haddock docking simulation that is based on i) NMR data that includes PRE-measurements between lipids (i.e. nanodisc) and the protien (i.e. K-RasGNP and A- ...詳細: This is a hybrid model generated by Haddock docking simulation that is based on i) NMR data that includes PRE-measurements between lipids (i.e. nanodisc) and the protien (i.e. K-RasGNP and A-RafRBD) ii) crystolagraphic information (K-RasGNP and A-RafRBD) and iii) theoretical computation (i.e. nanodisc). | ||||||||||||||||||||
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NMR実験 |
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NMR実験の詳細 | Text: All PRE measurements were carrried out on the C-delta of Ile residues. |
-試料調製
詳細 |
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試料 |
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