Entry Database : PDB / ID : 2mho Structure visualization Downloads & linksTitle Solution State Structure PSD-95 PDZ1 with 5HT2C Receptor peptide ComponentsDisks large homolog 4 peptide from 5-hydroxytryptamine receptor 2C DetailsKeywords PROTEIN BINDING / PDZ / 5-hydroxytryptamine receptor fragment / PSD-95Function / homology Function and homology informationFunction Domain/homology Component
Serotonin receptors / : / : / regulation of corticotropin-releasing hormone secretion / negative regulation of locomotion / : / phospholipase D-activating G protein-coupled receptor signaling pathway / 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding / RHO GTPases activate CIT / Gq/11-coupled serotonin receptor activity ... Serotonin receptors / : / : / regulation of corticotropin-releasing hormone secretion / negative regulation of locomotion / : / phospholipase D-activating G protein-coupled receptor signaling pathway / 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding / RHO GTPases activate CIT / Gq/11-coupled serotonin receptor activity / phospholipase C-activating serotonin receptor signaling pathway / positive regulation of phosphatidylinositol biosynthetic process / regulation of appetite / positive regulation of AMPA glutamate receptor clustering / neuronal ion channel clustering / P2Y1 nucleotide receptor binding / Neurexins and neuroligins / beta-1 adrenergic receptor binding / positive regulation of acetylcholine secretion, neurotransmission / neuroligin family protein binding / regulation of nervous system process / response to xenobiotic stimulus => GO:0009410 / structural constituent of postsynaptic density / proximal dendrite / positive regulation of gamma-aminobutyric acid secretion / positive regulation of neuron projection arborization / regulation of grooming behavior / synaptic vesicle maturation / serotonin receptor signaling pathway / embryo development / regulation of sensory perception of pain / receptor localization to synapse / cerebellar mossy fiber / behavioral response to nicotine / cellular response to potassium ion / negative regulation of dopamine metabolic process / protein localization to synapse / vocalization behavior / LGI-ADAM interactions / Trafficking of AMPA receptors / dendritic branch / neuron spine / Activation of Ca-permeable Kainate Receptor / serotonin binding / AMPA glutamate receptor clustering / G protein-coupled serotonin receptor activity / dendritic spine morphogenesis / juxtaparanode region of axon / frizzled binding / negative regulation of receptor internalization / dendritic spine organization / neuron projection terminus / acetylcholine receptor binding / postsynaptic neurotransmitter receptor diffusion trapping / feeding behavior / establishment or maintenance of epithelial cell apical/basal polarity / G alpha (q) signalling events / positive regulation of synapse assembly / Synaptic adhesion-like molecules / regulation of NMDA receptor activity / RAF/MAP kinase cascade / neurotransmitter receptor localization to postsynaptic specialization membrane / positive regulation of dendrite morphogenesis / neurotransmitter receptor activity / cortical cytoskeleton / cGMP-mediated signaling / locomotory exploration behavior / regulation of neuronal synaptic plasticity / plasma membrane => GO:0005886 / kinesin binding / positive regulation of excitatory postsynaptic potential / social behavior / AMPA glutamate receptor complex / G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger / neuromuscular process controlling balance / excitatory synapse / positive regulation of protein tyrosine kinase activity / D1 dopamine receptor binding / Unblocking of NMDA receptors, glutamate binding and activation / behavioral fear response / positive regulation of fat cell differentiation / glutamate receptor binding / positive regulation of synaptic transmission / animal organ regeneration / beta-2 adrenergic receptor binding / release of sequestered calcium ion into cytosol / positive regulation of vasoconstriction / extrinsic component of cytoplasmic side of plasma membrane / dendrite cytoplasm / synaptic membrane / locomotory behavior / PDZ domain binding / cell periphery / G protein-coupled receptor activity / postsynaptic density membrane / ionotropic glutamate receptor binding / regulation of long-term neuronal synaptic plasticity / establishment of protein localization / neuromuscular junction / cerebral cortex development Similarity search - Function 5-Hydroxytryptamine 2C receptor / Polyubiquitination (PEST) N-terminal domain of MAGUK / 5-hydroxytryptamine receptor family / Disks large homologue 1, N-terminal PEST domain / Polyubiquitination (PEST) N-terminal domain of MAGUK / PDZ-associated domain of NMDA receptors / PDZ-associated domain of NMDA receptors / Disks large 1-like / Guanylate kinase, conserved site / Guanylate kinase-like signature. ... 5-Hydroxytryptamine 2C receptor / Polyubiquitination (PEST) N-terminal domain of MAGUK / 5-hydroxytryptamine receptor family / Disks large homologue 1, N-terminal PEST domain / Polyubiquitination (PEST) N-terminal domain of MAGUK / PDZ-associated domain of NMDA receptors / PDZ-associated domain of NMDA receptors / Disks large 1-like / Guanylate kinase, conserved site / Guanylate kinase-like signature. / Guanylate kinase-like domain profile. / Guanylate kinase-like domain / Guanylate kinase/L-type calcium channel beta subunit / Guanylate kinase / Guanylate kinase homologues. / PDZ domain / Pdz3 Domain / Serpentine type 7TM GPCR chemoreceptor Srsx / PDZ domain / SH3 domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / Src homology 3 domains / G-protein coupled receptors family 1 signature. / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family) / Roll / P-loop containing nucleoside triphosphate hydrolase / Mainly Beta Similarity search - Domain/homologyBiological species Rattus norvegicus (Norway rat)Method SOLUTION NMR / torsion angle dynamics , simulated annealing , simulated annealing DetailsModel details closest to the average, model5 Authors Dorr, L.A. / Phelan, M.M. / Lian, L. CitationJournal : To be Published Title : Interactions of the 5-Hydroxytryptamine Receptor 2a and 2c Variants with the PSD-MAGUK proteins, PSD-95 and SAP997Authors : Dorr, L.A. / Phelan, M.M. / Lian, L. History Deposition Nov 29, 2013 Deposition site : BMRB / Processing site : RCSBRevision 1.0 Mar 12, 2014 Provider : repository / Type : Initial releaseRevision 1.1 May 1, 2024 Group : Data collection / Database referencesCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_nmr_software / pdbx_nmr_spectrometer / struct_ref_seq_dif Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_software.name / _pdbx_nmr_spectrometer.model / _struct_ref_seq_dif.details
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