Entry Database : PDB / ID : 2m48 Structure visualization Downloads & linksTitle Solution Structure of IBR-RING2 Tandem Domain from Parkin ComponentsE3 UBIQUITIN-PROTEIN LIGASE PARKIN Details Keywords LIGASE / Parkin / RING / IBR / E3 ligase / Zn-bindingFunction / homology Function and homology informationFunction Domain/homology Component
positive regulation of compound eye pigmentation / positive regulation of locomotor rhythm / PINK1-PRKN Mediated Mitophagy / Josephin domain DUBs / sperm mitochondrion organization / larval locomotory behavior / Antigen processing: Ubiquitination & Proteasome degradation / Aggrephagy / parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization / positive regulation of neuronal action potential ... positive regulation of compound eye pigmentation / positive regulation of locomotor rhythm / PINK1-PRKN Mediated Mitophagy / Josephin domain DUBs / sperm mitochondrion organization / larval locomotory behavior / Antigen processing: Ubiquitination & Proteasome degradation / Aggrephagy / parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization / positive regulation of neuronal action potential / negative regulation of mitochondrial fusion / RBR-type E3 ubiquitin transferase / positive regulation of autophagy of mitochondrion / positive regulation of mitophagy / regulation of cellular response to oxidative stress / autophagy of mitochondrion / negative regulation of JNK cascade / mitochondrial fission / ubiquitin conjugating enzyme binding / regulation of mitochondrion organization / positive regulation of mitochondrial fission / oogenesis / protein monoubiquitination / protein autoubiquitination / ubiquitin ligase complex / mitochondrion organization / adult locomotory behavior / negative regulation of protein phosphorylation / neuron cellular homeostasis / protein polyubiquitination / ubiquitin-protein transferase activity / ubiquitin protein ligase activity / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / ubiquitin-dependent protein catabolic process / spermatogenesis / regulation of apoptotic process / response to oxidative stress / protein ubiquitination / Golgi apparatus / endoplasmic reticulum / mitochondrion / zinc ion binding / cytoplasm / cytosol Similarity search - Function : / : / : / E3 ubiquitin-protein ligase parkin / RING/Ubox-like zinc-binding domain / Parkin, RING/Ubox like zinc-binding domain / RING/Ubox like zinc-binding domain / RING/Ubox like zinc-binding domain / E3 ubiquitin ligase RBR family / IBR domain ... : / : / : / E3 ubiquitin-protein ligase parkin / RING/Ubox-like zinc-binding domain / Parkin, RING/Ubox like zinc-binding domain / RING/Ubox like zinc-binding domain / RING/Ubox like zinc-binding domain / E3 ubiquitin ligase RBR family / IBR domain / In Between Ring fingers / TRIAD supradomain / TRIAD supradomain profile. / Ubiquitin family / Ubiquitin homologues / Ubiquitin domain profile. / Ubiquitin-like domain / Zinc finger, RING/FYVE/PHD-type / Ubiquitin-like domain superfamily Similarity search - Domain/homologyBiological species Drosophila melanogaster (fruit fly)Method SOLUTION NMR / torsion angle dynamics DetailsModel details closest to the average, model 11 Authors Noh, Y.J. / Mercier, P. / Spratt, D.E. / Shaw, G.S. CitationJournal : Nat Commun / Year : 2013Title : A molecular explanation for the recessive nature of parkin-linked Parkinson's disease.Authors : Spratt, D.E. / Julio Martinez-Torres, R. / Noh, Y.J. / Mercier, P. / Manczyk, N. / Barber, K.R. / Aguirre, J.D. / Burchell, L. / Purkiss, A. / Walden, H. / Shaw, G.S. History Deposition Jan 30, 2013 Deposition site : BMRB / Processing site : RCSBRevision 1.0 May 15, 2013 Provider : repository / Type : Initial releaseRevision 1.1 Jul 10, 2013 Group : Database referencesRevision 1.2 Oct 15, 2014 Group : Structure summaryRevision 1.3 Mar 13, 2024 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Source and taxonomy Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / entity_src_gen / pdbx_nmr_software / pdbx_struct_conn_angle / struct_conn / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_software.name / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id Revision 1.4 May 15, 2024 Group : Database references / Category : database_2 / Item : _database_2.pdbx_DOI
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