Entry Database : PDB / ID : 2lct Structure visualization Downloads & linksTitle Solution structure of the Vav1 SH2 domain complexed with a Syk-derived doubly phosphorylated peptide ComponentsProto-oncogene vav Tyrosine-protein kinase SYK DetailsKeywords SIGNALING PROTEIN / Phosphopeptide / Syk kinase / tyrosine kinase / protein-peptide complex / phosphorylated peptide / phosphotyrosine binding domain / B cell signaling proteinFunction / homology Function and homology informationFunction Domain/homology Component
FLT3 signaling through SRC family kinases / Interleukin-2 signaling / serotonin secretion / Fc epsilon receptor (FCERI) signaling / Dectin-2 family / Signaling by CSF3 (G-CSF) / Role of LAT2/NTAL/LAB on calcium mobilization / GPVI-mediated activation cascade / FCERI mediated MAPK activation / Inactivation of CSF3 (G-CSF) signaling ... FLT3 signaling through SRC family kinases / Interleukin-2 signaling / serotonin secretion / Fc epsilon receptor (FCERI) signaling / Dectin-2 family / Signaling by CSF3 (G-CSF) / Role of LAT2/NTAL/LAB on calcium mobilization / GPVI-mediated activation cascade / FCERI mediated MAPK activation / Inactivation of CSF3 (G-CSF) signaling / FCGR activation / Role of phospholipids in phagocytosis / Integrin signaling / FCERI mediated Ca+2 mobilization / interleukin-15 receptor binding / regulation of superoxide anion generation / regulation of neutrophil degranulation / regulation of arachidonate secretion / cellular response to lectin / gamma-delta T cell differentiation / serotonin secretion by platelet / positive regulation of interleukin-3 production / positive regulation of gamma-delta T cell differentiation / phosphorylation-dependent protein binding / B cell receptor complex / Antigen activates B Cell Receptor (BCR) leading to generation of second messengers / Toll-like receptor binding / Regulation of signaling by CBL / regulation of platelet aggregation / Regulation of actin dynamics for phagocytic cup formation / positive regulation of alpha-beta T cell proliferation / leukocyte activation involved in immune response / neutrophil activation involved in immune response / positive regulation of mast cell cytokine production / positive regulation of natural killer cell mediated cytotoxicity / positive regulation of mast cell degranulation / lymph vessel development / regulation of platelet activation / collagen-activated tyrosine kinase receptor signaling pathway / cell activation / positive regulation of killing of cells of another organism / regulation of phagocytosis / beta selection / macrophage activation involved in immune response / cellular response to molecule of fungal origin / early phagosome / leukotriene biosynthetic process / regulation of tumor necrosis factor-mediated signaling pathway / positive regulation of monocyte chemotactic protein-1 production / interleukin-3-mediated signaling pathway / cellular response to lipid / positive regulation of cell adhesion mediated by integrin / Azathioprine ADME / regulation of small GTPase mediated signal transduction / positive regulation of granulocyte macrophage colony-stimulating factor production / positive regulation of alpha-beta T cell differentiation / blood vessel morphogenesis / CD28 dependent Vav1 pathway / DAP12 signaling / natural killer cell mediated cytotoxicity / T cell receptor complex / positive regulation of B cell differentiation / leukocyte cell-cell adhesion / regulation of cell size / regulation of GTPase activity / mast cell degranulation / Fc-gamma receptor signaling pathway involved in phagocytosis / NRAGE signals death through JNK / enzyme-linked receptor protein signaling pathway / positive regulation of interleukin-4 production / stimulatory C-type lectin receptor signaling pathway / Fc-epsilon receptor signaling pathway / phospholipase binding / positive regulation of receptor internalization / positive regulation of interleukin-10 production / cellular response to low-density lipoprotein particle stimulus / T cell differentiation / Interleukin-3, Interleukin-5 and GM-CSF signaling / RHOG GTPase cycle / RHOA GTPase cycle / regulation of immune response / positive regulation of type I interferon production / RAC2 GTPase cycle / positive regulation of bone resorption / phosphatase binding / vascular endothelial growth factor receptor signaling pathway / Erythropoietin activates RAS / cell surface receptor protein tyrosine kinase signaling pathway / GPVI-mediated activation cascade / T cell costimulation / RAC1 GTPase cycle / positive regulation of TORC1 signaling / positive regulation of interleukin-12 production / positive regulation of calcium-mediated signaling / neutrophil chemotaxis / phosphotyrosine residue binding / reactive oxygen species metabolic process / FCERI mediated Ca+2 mobilization / SH2 domain binding / B cell differentiation Similarity search - Function VAV1 protein, second SH3 domain / VAV1 protein, first SH3 domain / VAV1, SH2 domain / Vav, PH domain / Smooth muscle protein/calponin / Calmodulin-regulated spectrin-associated protein-like, Calponin-homology domain / CAMSAP CH domain / Tyrosine-protein kinase, non-receptor SYK/ZAP-70 / Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain superfamily / SYK/ZAP-70, N-terminal SH2 domain ... VAV1 protein, second SH3 domain / VAV1 protein, first SH3 domain / VAV1, SH2 domain / Vav, PH domain / Smooth muscle protein/calponin / Calmodulin-regulated spectrin-associated protein-like, Calponin-homology domain / CAMSAP CH domain / Tyrosine-protein kinase, non-receptor SYK/ZAP-70 / Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain superfamily / SYK/ZAP-70, N-terminal SH2 domain / Guanine-nucleotide dissociation stimulator, CDC24, conserved site / Dbl homology (DH) domain signature. / Calponin homology domain / Phorbol esters/diacylglycerol binding domain (C1 domain) / Dbl homology (DH) domain superfamily / RhoGEF domain / Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases / Dbl homology (DH) domain / Dbl homology (DH) domain profile. / Calponin homology domain / CH domain superfamily / Calponin homology (CH) domain profile. / SH2 domain / SHC Adaptor Protein / Zinc finger phorbol-ester/DAG-type signature. / Zinc finger phorbol-ester/DAG-type profile. / Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) / Protein kinase C-like, phorbol ester/diacylglycerol-binding domain / : / PH domain / PH domain profile. / Pleckstrin homology domain. / Pleckstrin homology domain / SH3 domain / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / Src homology 3 domains / SH2 domain superfamily / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / PH-like domain superfamily / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Mus musculus (house mouse)Method SOLUTION NMR / simulated annealing DetailsModel details lowest energy, model 1 Authors Chen, C. / Gorenstein, N. / Post, C. CitationJournal : Mol.Cell.Biol. / Year : 2011Title : Two closely spaced tyrosines regulate NFAT signaling in B cells via Syk association with Vav.Authors : Chen, C.H. / Martin, V.A. / Gorenstein, N.M. / Geahlen, R.L. / Post, C.B. History Deposition May 9, 2011 Deposition site : BMRB / Processing site : RCSBRevision 1.0 Jun 1, 2011 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2011 Group : Version format complianceRevision 1.2 May 23, 2012 Group : Database referencesRevision 1.3 Jun 14, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other Category : database_2 / pdbx_database_status ... database_2 / pdbx_database_status / pdbx_nmr_software / pdbx_nmr_spectrometer / struct_conn / struct_ref_seq_dif Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_nmr_data / _pdbx_nmr_software.name / _pdbx_nmr_spectrometer.model / _struct_conn.pdbx_leaving_atom_flag / _struct_ref_seq_dif.details
Show all Show less