- PDB-2lbm: Solution structure of the ADD domain of ATRX complexed with histo... -
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Basic information
Entry
Database: PDB / ID: 2lbm
Title
Solution structure of the ADD domain of ATRX complexed with histone tail H3 1-15 K9me3
Components
Transcriptional regulator ATRX
histone tail H3 K9me3
Keywords
METAL BINDING PROTEIN/STRUCTURAL PROTEIN / histone tail / METAL BINDING PROTEIN-STRUCTURAL PROTEIN complex
Function / homology
Function and homology information
post-embryonic forelimb morphogenesis / Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations / Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations / negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric / positive regulation of nuclear cell cycle DNA replication / chromosome, subtelomeric region / chromosome organization involved in meiotic cell cycle / Sertoli cell development / cellular response to hydroxyurea / chromo shadow domain binding ...post-embryonic forelimb morphogenesis / Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations / Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations / negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric / positive regulation of nuclear cell cycle DNA replication / chromosome, subtelomeric region / chromosome organization involved in meiotic cell cycle / Sertoli cell development / cellular response to hydroxyurea / chromo shadow domain binding / DNA translocase activity / meiotic spindle organization / condensed chromosome, centromeric region / histone H3K9me2/3 reader activity / protein localization to chromosome, telomeric region / nuclear chromosome / seminiferous tubule development / : / forebrain development / positive regulation of telomere maintenance / replication fork processing / subtelomeric heterochromatin formation / pericentric heterochromatin / heterochromatin / Chromatin modifying enzymes / telomere organization / Interleukin-7 signaling / Inhibition of DNA recombination at telomere / RNA Polymerase I Promoter Opening / Assembly of the ORC complex at the origin of replication / Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex / DNA methylation / epigenetic regulation of gene expression / Condensation of Prophase Chromosomes / Chromatin modifications during the maternal to zygotic transition (MZT) / SIRT1 negatively regulates rRNA expression / HCMV Late Events / ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression / PRC2 methylates histones and DNA / Regulation of endogenous retroelements by KRAB-ZFP proteins / Defective pyroptosis / HDACs deacetylate histones / Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) / DNA damage response, signal transduction by p53 class mediator / RNA Polymerase I Promoter Escape / Transcriptional regulation by small RNAs / helicase activity / Formation of the beta-catenin:TCF transactivating complex / RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function / Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 / HDMs demethylate histones / PML body / NoRC negatively regulates rRNA expression / chromatin DNA binding / B-WICH complex positively regulates rRNA expression / PKMTs methylate histone lysines / Meiotic recombination / Pre-NOTCH Transcription and Translation / RMTs methylate histone arginines / multicellular organism growth / Activation of anterior HOX genes in hindbrain development during early embryogenesis / Transcriptional regulation of granulopoiesis / HCMV Early Events / structural constituent of chromatin / nucleosome / nucleosome assembly / RUNX1 regulates transcription of genes involved in differentiation of HSCs / HATs acetylate histones / Factors involved in megakaryocyte development and platelet production / chromatin organization / MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis / Senescence-Associated Secretory Phenotype (SASP) / spermatogenesis / Oxidative Stress Induced Senescence / histone binding / gene expression / DNA helicase / Estrogen-dependent gene expression / transcription by RNA polymerase II / chromosome, telomeric region / nuclear body / cadherin binding / chromatin remodeling / Amyloid fiber formation / protein heterodimerization activity / DNA repair / chromatin binding / regulation of DNA-templated transcription / positive regulation of transcription by RNA polymerase II / protein-containing complex / ATP hydrolysis activity / DNA binding / extracellular exosome / extracellular region / zinc ion binding / nucleoplasm / ATP binding / nucleus / membrane Similarity search - Function
NOE constraints total: 1582 / NOE intraresidue total count: 497 / NOE long range total count: 377 / NOE medium range total count: 312 / NOE sequential total count: 339 / Hydrogen bond constraints total count: 40 / Protein chi angle constraints total count: 30 / Protein other angle constraints total count: 0 / Protein phi angle constraints total count: 0 / Protein psi angle constraints total count: 0
NMR representative
Selection criteria: lowest energy
NMR ensemble
Conformer selection criteria: structures with the lowest energy Conformers calculated total number: 50 / Conformers submitted total number: 25 / Maximum torsion angle constraint violation: 5.19 ° / Maximum upper distance constraint violation: 0.31 Å / Representative conformer: 1
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