Entry | Database: PDB / ID: 2l9r |
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Title | Solution NMR Structure of Homeobox domain of Homeobox protein Nkx-3.1 from homo sapiens, Northeast Structural Genomics Consortium Target HR6470A |
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Components | Homeobox protein Nkx-3.1 |
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Keywords | TRANSCRIPTION / Structural Genomics / NORTHEAST STRUCTURAL GENOMICS CONSORTIUM / NESG / PSI-Biology / Protein Structure Initiative / transcription factor / Methods Development |
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Function / homology | Function and homology information
: / MADS box domain binding / positive regulation of androgen secretion / regulation of cell cycle => GO:0051726 / salivary gland development / : / dorsal aorta development / : / cellular response to xenobiotic stimulus => GO:0071466 / : ...: / MADS box domain binding / positive regulation of androgen secretion / regulation of cell cycle => GO:0051726 / salivary gland development / : / dorsal aorta development / : / cellular response to xenobiotic stimulus => GO:0071466 / : / negative regulation of insulin-like growth factor receptor signaling pathway / : / negative regulation of epithelial cell proliferation involved in prostate gland development / multicellular organism development / chromatin => GO:0000785 / epithelial cell proliferation involved in salivary gland morphogenesis / branching involved in prostate gland morphogenesis / pharyngeal system development / metanephros development / cellular response to steroid hormone stimulus / branching morphogenesis of an epithelial tube / response to testosterone / nuclear estrogen receptor activity / positive regulation of cysteine-type endopeptidase activity involved in apoptotic process / androgen receptor signaling pathway / site of DNA damage / cysteine-type endopeptidase activator activity involved in apoptotic process / transcription factor binding / positive regulation of cell division / negative regulation of mitotic cell cycle / cellular response to interleukin-1 / somitogenesis / positive regulation of intrinsic apoptotic signaling pathway / phosphatidylinositol 3-kinase/protein kinase B signal transduction / positive regulation of mitotic cell cycle / positive regulation of apoptotic signaling pathway / nuclear estrogen receptor binding / positive regulation of DNA-binding transcription factor activity / histone deacetylase binding / activation of cysteine-type endopeptidase activity involved in apoptotic process / negative regulation of epithelial cell proliferation / nuclear receptor activity / male gonad development / regulation of protein localization / sequence-specific double-stranded DNA binding / cellular response to tumor necrosis factor / heart development / cellular response to hypoxia / sequence-specific DNA binding / cell differentiation / DNA-binding transcription factor activity, RNA polymerase II-specific / transcription cis-regulatory region binding / positive regulation of protein phosphorylation / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / negative regulation of cell population proliferation / negative regulation of gene expression / negative regulation of DNA-templated transcription / positive regulation of cell population proliferation / regulation of DNA-templated transcription / positive regulation of gene expression / positive regulation of DNA-templated transcription / positive regulation of transcription by RNA polymerase II / nucleoplasm / nucleus / cytosolSimilarity search - Function Homeobox domain, metazoa / Homeobox, conserved site / 'Homeobox' domain signature. / Homeodomain / 'Homeobox' domain profile. / Homeodomain / Homeobox domain / Homeodomain-like / Homeobox-like domain superfamily / Arc Repressor Mutant, subunit A ...Homeobox domain, metazoa / Homeobox, conserved site / 'Homeobox' domain signature. / Homeodomain / 'Homeobox' domain profile. / Homeodomain / Homeobox domain / Homeodomain-like / Homeobox-like domain superfamily / Arc Repressor Mutant, subunit A / Orthogonal Bundle / Mainly AlphaSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | SOLUTION NMR / distance geometry, torsion angle dynamics, molecular dynamics |
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Model details | lowest energy, model 1 |
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Authors | Liu, G. / Xiao, R. / Lee, H.-W. / Hamilton, K. / Ciccosanti, C. / Wang, H.B. / Acton, T.B. / Everett, J.K. / Huang, Y.J. / Montelione, G.T. / Northeast Structural Genomics Consortium (NESG) |
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Citation | Journal: To be Published Title: Solution NMR Structure of Homeobox domain of Homeobox protein Nkx-3.1 from homo sapiens, Northeast Structural Genomics Consortium Target HR6470A Authors: Liu, G. / Xiao, R. / Lee, H.-W. / Hamilton, K. / Ciccosanti, C. / Wang, H.B. / Acton, T.B. / Everett, J.K. / Huang, Y.J. / Montelione, G.T. |
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History | Deposition | Feb 22, 2011 | Deposition site: BMRB / Processing site: RCSB |
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Revision 1.0 | Apr 20, 2011 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jul 13, 2011 | Group: Version format compliance |
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Revision 1.2 | Feb 22, 2012 | Group: Structure summary |
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Revision 1.3 | Jun 14, 2023 | Group: Data collection / Database references / Other Category: database_2 / pdbx_database_status ...database_2 / pdbx_database_status / pdbx_nmr_software / pdbx_nmr_spectrometer / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_nmr_data / _pdbx_nmr_software.name / _pdbx_nmr_spectrometer.model / _struct_ref_seq_dif.details |
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Revision 1.4 | May 15, 2024 | Group: Data collection / Database references / Category: chem_comp_atom / chem_comp_bond / database_2 / Item: _database_2.pdbx_DOI |
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