Entry Database : PDB / ID : 2l5e Structure visualization Downloads & linksTitle Complex between BD1 of Brd3 and GATA-1 C-tail ComponentsBromodomain-containing protein 3 GATA-1 DetailsKeywords NUCLEAR PROTEIN/TRANSCRIPTION / GATA-1 / Brd3 / histone code / NUCLEAR PROTEIN-TRANSCRIPTION complexFunction / homology Function and homology informationFunction Domain/homology Component
regulation of primitive erythrocyte differentiation / basophil differentiation / eosinophil fate commitment / regulation of definitive erythrocyte differentiation / regulation of glycoprotein biosynthetic process / myeloid cell apoptotic process / primitive erythrocyte differentiation / megakaryocyte differentiation / osteoblast proliferation / cell development ... regulation of primitive erythrocyte differentiation / basophil differentiation / eosinophil fate commitment / regulation of definitive erythrocyte differentiation / regulation of glycoprotein biosynthetic process / myeloid cell apoptotic process / primitive erythrocyte differentiation / megakaryocyte differentiation / osteoblast proliferation / cell development / RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function / Sertoli cell development / RUNX1 regulates transcription of genes involved in differentiation of HSCs / dendritic cell differentiation / cellular response to follicle-stimulating hormone stimulus / negative regulation of bone mineralization / Factors involved in megakaryocyte development and platelet production / negative regulation of myeloid cell apoptotic process / positive regulation of mast cell degranulation / myeloid cell differentiation / C2H2 zinc finger domain binding / embryonic hemopoiesis / platelet formation / bone mineralization / positive regulation of osteoblast proliferation / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand / cell fate commitment / animal organ regeneration / cis-regulatory region sequence-specific DNA binding / erythrocyte development / cellular response to cAMP / homeostasis of number of cells within a tissue / transcription repressor complex / erythrocyte differentiation / positive regulation of erythrocyte differentiation / transcription coregulator binding / protein-DNA complex / lysine-acetylated histone binding / chromatin DNA binding / transcription coactivator binding / platelet aggregation / positive regulation of peptidyl-tyrosine phosphorylation / p53 binding / cell-cell signaling / chromatin organization / positive regulation of cytosolic calcium ion concentration / DNA-binding transcription activator activity, RNA polymerase II-specific / cellular response to lipopolysaccharide / in utero embryonic development / RNA polymerase II-specific DNA-binding transcription factor binding / cell population proliferation / sequence-specific DNA binding / transcription by RNA polymerase II / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / negative regulation of cell population proliferation / chromatin binding / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / DNA binding / zinc ion binding / nucleoplasm / nucleus Similarity search - Function Transcription factor GATA / GATA-type zinc finger domain. / GATA-type zinc finger domain profile. / zinc finger binding to DNA consensus sequence [AT]GATA[AG] / GATA zinc finger / Zinc finger, GATA-type / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I ... Transcription factor GATA / GATA-type zinc finger domain. / GATA-type zinc finger domain profile. / zinc finger binding to DNA consensus sequence [AT]GATA[AG] / GATA zinc finger / Zinc finger, GATA-type / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like / Histone Acetyltransferase; Chain A / Zinc finger, NHR/GATA-type / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily / Up-down Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Mus musculus (house mouse)Method SOLUTION NMR / torsion angle dynamics DetailsModel details lowest energy, model 1 Authors Gamsjaeger, R. / Webb, S.R. / Lamonica, J.M. / Blobel, G.A. / Mackay, J.P. CitationJournal : Mol. Cell. Biol. / Year : 2011Title : Structural basis and specificity of acetylated transcription factor GATA1 recognition by BET family bromodomain protein Brd3.Authors : Gamsjaeger, R. / Webb, S.R. / Lamonica, J.M. / Billin, A. / Blobel, G.A. / Mackay, J.P. History Deposition Oct 31, 2010 Deposition site : BMRB / Processing site : PDBJRevision 1.0 May 18, 2011 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2011 Group : Version format complianceRevision 1.2 Jul 26, 2017 Group : Database references / Category : citationItem : _citation.journal_abbrev / _citation.journal_volume ... _citation.journal_abbrev / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title Revision 1.3 Feb 26, 2020 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other Category : database_2 / pdbx_database_status ... database_2 / pdbx_database_status / pdbx_nmr_spectrometer / struct_conn / struct_ref_seq_dif Item : _pdbx_database_status.status_code_cs / _pdbx_nmr_spectrometer.model ... _pdbx_database_status.status_code_cs / _pdbx_nmr_spectrometer.model / _struct_conn.pdbx_leaving_atom_flag / _struct_ref_seq_dif.details Revision 2.0 Nov 15, 2023 Group : Atomic model / Data collection / Database referencesCategory : atom_site / chem_comp_atom ... atom_site / chem_comp_atom / chem_comp_bond / database_2 Item : _atom_site.auth_atom_id / _atom_site.label_atom_id ... _atom_site.auth_atom_id / _atom_site.label_atom_id / _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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